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Context Info
Confidence 0.76
First Reported 1996
Last Reported 2010
Negated 2
Speculated 4
Reported most in Body
Documents 41
Total Number 49
Disease Relevance 37.89
Pain Relevance 3.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (TWIST1) DNA binding (TWIST1) transcription factor binding (TWIST1)
Anatomy Link Frequency
muscle 4
lymph node 2
liver 2
epithelial cells 2
blood 2
TWIST1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal-cord stimulation 33 100.00 Very High Very High Very High
Spinal cord 5 99.42 Very High Very High Very High
Sciatic nerve 1 98.68 Very High Very High Very High
tolerance 15 97.24 Very High Very High Very High
Inflammatory response 1 97.08 Very High Very High Very High
headache 2 92.96 High High
Peripheral nervous system 4 91.32 High High
cytokine 103 88.28 High High
Inflammation 21 87.12 High High
cva 3 86.64 High High
Disease Link Frequency Relevance Heat
Wallerian Degeneration 2 99.96 Very High Very High Very High
Pancreatitis 40 99.88 Very High Very High Very High
Pancreatic Cancer 56 99.84 Very High Very High Very High
Prostate Cancer 690 99.76 Very High Very High Very High
Cervical Cancer 4 99.72 Very High Very High Very High
Metastasis 260 99.40 Very High Very High Very High
Adenocarcinoma 83 99.32 Very High Very High Very High
Cancer 1375 99.08 Very High Very High Very High
Brain Tumor 1 99.00 Very High Very High Very High
Reprotox - General 1 24 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To clarify involvement of Twist expression in pancreatic cancer, we used quantitative reverse transcription-polymerase chain reaction and examined Twist expression in pancreatic cancer, IPMN, and non-neoplastic pancreas using bulk tissues (11 cancers, 18 IPMNs, and 15 non-neoplastic pancreata), microdissected cells (cancer from 22 sections, IPMN from 19 sections, PanIN from 6 sections, and pancreatitis-affected epithelial cells from 14 sections), and pancreatic juice (16 from cancer, 28 from IPMN, and 17 from pancreatitis).
Gene_expression (expression) of Twist in epithelial cells associated with cancer, pancreatitis and pancreatic cancer
1) Confidence 0.76 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17236203 Disease Relevance 1.61 Pain Relevance 0
Previous studies of these genes, including markers of toxic stress, apoptosis, growth regulation and repair, were consistent with documented toxicologic responses to CCl4, where expression of components of cytochrome P450 and other metabolic enzymes (Cyp2C, Cyp3A18, Cyp3A9, SCS and Fmo1) were found to decrease, whereas certain genes involved in the inflammatory response and signal transduction were increased (CD44 and Lgals3) [7].
Gene_expression (expression) of SCS associated with stress, inflammatory response and apoptosis
2) Confidence 0.75 Published 2003 Journal Genome Biol Section Body Doc Link PMC156588 Disease Relevance 0.42 Pain Relevance 0.05
PanIN cells expressed significantly lower levels of Twist than did IDC cells (p = 0.016).
Gene_expression (expressed) of Twist
3) Confidence 0.66 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17236203 Disease Relevance 2.47 Pain Relevance 0.07
Despite evidence that Twist, a highly conserved basic helix-loop-helix transcription factor, is a novel oncogene, there are no reports describing Twist expression in pancreatic cancer.
Gene_expression (expression) of Twist associated with pancreatic cancer
4) Confidence 0.66 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17236203 Disease Relevance 1.02 Pain Relevance 0
The authors found that SCS can produce either an increase of CBF or a reduction or no effect.
Neg (no) Gene_expression (produce) of SCS associated with spinal-cord stimulation
5) Confidence 0.64 Published 2008 Journal J Neurosurg Sci Section Abstract Doc Link 18500217 Disease Relevance 0.60 Pain Relevance 0.49
In this patient cohort, TWIST1 expression could not predict progression, as it did not differ between non-progressive organ-confined tumors and primary cancers that eventually developed metastasis.
Gene_expression (expression) of TWIST1 associated with cancer and metastasis
6) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 1.73 Pain Relevance 0
Quantitative PCR confirmed overexpression of TWIST1 in primary PCa samples and lymph node metastasis (Fig. 5A).
Gene_expression (overexpression) of TWIST1 in lymph node associated with prostate cancer and metastasis
7) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 1.73 Pain Relevance 0
The fact that TWIST1 and DKK3 expression was deregulated in both hormone-refractory and hormone-naïve patient samples, suggests that these alterations occur earlier in PCa progression and do not act alone in inducing therapy-resistant growth.
Gene_expression (expression) of TWIST1 associated with prostate cancer
8) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.95 Pain Relevance 0.04
Furthermore, TWIST1 expression was not increased in hormone-refractory tumors when compared to hormone-naïve samples, suggesting that TWIST1 overexpression alone may not be enough to confer hormone-refractory growth.
Gene_expression (expression) of TWIST1 associated with cancer
9) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 1.63 Pain Relevance 0
Furthermore, TWIST1 expression was not increased in hormone-refractory tumors when compared to hormone-naïve samples, suggesting that TWIST1 overexpression alone may not be enough to confer hormone-refractory growth.
Gene_expression (overexpression) of TWIST1 associated with cancer
10) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 1.52 Pain Relevance 0
We quantified TWIST1 expression in a panel of patient derived material, comprising 21 normal prostate samples (adjacent to cancer), 74 primary prostate tumors, of which 9 hormone-refractory samples, and 13 lymph node metastasis.
Gene_expression (expression) of TWIST1 in lymph node associated with cancer, prostate cancer and metastasis
11) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 1.32 Pain Relevance 0
VAV3 and TWIST1 are potential oncogenes, and while VAV3 can interact with and cross-activate signaling via hormone and growth receptors, expression of TWIST1 is in turn stimulated by EGF and IGF1 [49], [50], [51], [52].
Gene_expression (expression) of TWIST1
12) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.09 Pain Relevance 0
Our group found that SCS can produce either an increase of CBF or a reduction or no effect.
Neg (no) Gene_expression (produce) of SCS associated with spinal-cord stimulation
13) Confidence 0.55 Published 2006 Journal Acta Neurochir. Suppl. Section Abstract Doc Link 17370775 Disease Relevance 0.11 Pain Relevance 0.33
Thirteen of the analyzed loci showed statistically significant differences in DNA methylation when AD samples were compared to all NTL samples: OPCML, CDX2, HOXA1, CDKN2A EX2, SFRP1, CDH13, TWIST1, LZTS1, RASSF1, SFRP4 and 5, ESR1, and CDH1.
Gene_expression (samples) of TWIST1 associated with adenocarcinoma
14) Confidence 0.55 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2206053 Disease Relevance 1.23 Pain Relevance 0
Twist expressions differed significantly between microdissected cancer cells, IPMN cells, and pancreatitis-affected cells (all comparisons, p < 0.017).
Gene_expression (expressions) of Twist associated with cancer and pancreatitis
15) Confidence 0.51 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17236203 Disease Relevance 2.46 Pain Relevance 0.06
Twist expression differed significantly between cancer and IPMN juice samples (p = 0.0002) but not between cancer and pancreatitis juice samples.
Gene_expression (expression) of Twist associated with cancer and pancreatitis
16) Confidence 0.51 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17236203 Disease Relevance 2.45 Pain Relevance 0.08
Twist, a novel oncogene, is upregulated in pancreatic cancer: clinical implication of Twist expression in pancreatic juice.
Gene_expression (expression) of Twist associated with pancreatic cancer
17) Confidence 0.51 Published 2007 Journal Int. J. Cancer Section Title Doc Link 17236203 Disease Relevance 1.64 Pain Relevance 0
Twist expression differed significantly between cancer and IPMN bulk tissues (p < 0.0001) but not between cancer and non-neoplastic tissues.
Gene_expression (expression) of Twist associated with cancer
18) Confidence 0.51 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17236203 Disease Relevance 2.17 Pain Relevance 0
To clarify involvement of Twist expression in pancreatic cancer, we used quantitative reverse transcription-polymerase chain reaction and examined Twist expression in pancreatic cancer, IPMN, and non-neoplastic pancreas using bulk tissues (11 cancers, 18 IPMNs, and 15 non-neoplastic pancreata), microdissected cells (cancer from 22 sections, IPMN from 19 sections, PanIN from 6 sections, and pancreatitis-affected epithelial cells from 14 sections), and pancreatic juice (16 from cancer, 28 from IPMN, and 17 from pancreatitis).
Spec (examined) Gene_expression (expression) of Twist in epithelial cells associated with cancer, pancreatitis and pancreatic cancer
19) Confidence 0.51 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17236203 Disease Relevance 1.82 Pain Relevance 0
In that study, TWIST1 expression bypassed P53-induced growth arrest and promoted colony formation, consistent with a potential role as oncoproteins [61].
Gene_expression (expression) of TWIST1
20) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.71 Pain Relevance 0

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