INT64862

Context Info Confidence 0.36 First Reported 1996 Last Reported 1999 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 0.76 Pain Relevance 1.09

small molecule metabolic process (PTGS2) endoplasmic reticulum (PTGS2) enzyme binding (PTGS2) protein complex (PTGS2) cytoplasm (PTGS2) lipid binding (PTGS2)

PTGS2 (Homo sapiens) PTGS2 - R106E (1)

Pain Link Frequency Relevance Heat Potency 6 100.00 COX2 2 100.00 cINOD 14 91.96 Osteoarthritis 1 86.84 diclofenac 1 85.28 Analgesic 1 39.72 Inflammation 1 38.60

Disease Link Frequency Relevance Heat Infertility 3 99.92 INFLAMMATION 6 99.34 Cleidocranial Dysplasia 1 87.92 Hip Osteoarthritis 1 86.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Nonsteroidal antiinflammatory drugs may induce infertility by reducing the production of prostaglandins, most notably via inhibition of the enzyme cyclooxygenase 2.

Negative_regulation (reducing) of Negative_regulation (inhibition) of cyclooxygenase 2 associated with inflammation, infertility and cox2

1) Confidence 0.36 Published 1999 Journal Rev Rhum Engl Ed Section Abstract Doc Link 10327496 Disease Relevance 0.64 Pain Relevance 0.17

The greatest loss of potency for inhibition of hPGHS-2(R106E) was observed with the hPGHS-2-selective sulfonamide-containing inhibitors NS-398 and flosulide.

Negative_regulation (loss) of Negative_regulation (inhibition) of hPGHS-2 (R106E) associated with potency

2) Confidence 0.27 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9351974 Disease Relevance 0.07 Pain Relevance 0.61

In contrast, the selective PGHS-2 inhibitor NS-398 exhibited time-independent inhibition of hPGHS-1 but time-dependent inhibition of hPGHS-2 in intact cells.

Negative_regulation (exhibited) of Negative_regulation (inhibition) of hPGHS-2

3) Confidence 0.18 Published 1996 Journal Biochem. Pharmacol. Section Abstract Doc Link 8831731 Disease Relevance 0.05 Pain Relevance 0.31

General Comments

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