INT65023

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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Disease Relevance
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| 0.14804
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| 0.15
 
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Pain Relevance
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| 8.46816
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| 5.08
 
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| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Enkephalin]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Enkephalin]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 31
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 31
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 100
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| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 100.00
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
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| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[mu opioid receptor]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[mu opioid receptor]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 46
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 46
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 100
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 100.00
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
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| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[amygdala]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[amygdala]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 8
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 8
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 98
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 98.00
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
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| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Ventral tegmentum]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Ventral tegmentum]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 4
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 4
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 95.4
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 95.40
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
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{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| Neurons with <span style="background-color:#FFFF00">mu opioid receptors</span> <span style="background-color:#B0E0E6">interact</span> indirectly with <span style="background-color:#FFFF00">enkephalin</span>-containing neurons in the rat <span style="background-color:#FFDEAD">dentate gyrus</span>.
+
| Neurons with <span style="background-color:#FFA07A">mu opioid receptors</span> <span style="background-color:#B0E0E6">interact</span> indirectly with <span style="background-color:#FFA07A">enkephalin</span>-containing neurons in the rat <span style="background-color:#FFDEAD">dentate gyrus</span>.
  
 
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{| cellpadding=4 cellspacing=2  
 
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| <span style="color:#800000">'''mu opioid receptors'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">interact</span>) of <span style="color:#800000">'''enkephalin'''</span> in <span style="color:#808000">dentate gyrus</span>
+
| <span style="color:#800000">'''mu opioid receptors'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">interact</span>) of <span style="color:#800000">'''enkephalin'''</span> in <span style="color:#808000">dentate gyrus</span> associated with <span style="color:#FF0000">'''mu opioid receptor'''</span> and <span style="color:#FF0000">'''enkephalin'''</span>
 
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=12093103 12093103]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=12093103 12093103]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.99
 
|}
 
|}
 
|-
 
|-
 
|}
 
|}
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| Following naltrexone administration, mu receptor immunoreactivity was significantly higher in the amygdala, thalamus, hippocampus, and interpeduncular nucleus as compared with the saline-treated control animals. [3H]D-Ala2,N-Me-Phe4,<span style="background-color:#FFFF00">Gly-ol5-enkephalin</span> <span style="background-color:#B0E0E6">binding</span> to <span style="background-color:#FFFF00">mu opioid receptors</span> was significantly higher in the globus pallidus, amygdala, thalamus, hypothalamus, hippocampus, substantia nigra, ventral tegmental area, central gray, and <span style="background-color:#FFDEAD">interpeduncular nucleus</span> of the naltrexone-treated rats.  
+
| Following naltrexone administration, mu receptor immunoreactivity was significantly higher in the <span style="background-color:#FFA07A">amygdala</span>, <span style="background-color:#FFA07A">thalamus</span>, <span style="background-color:#FFA07A">hippocampus</span>, and interpeduncular nucleus as compared with the saline-treated control animals. [3H]D-Ala2,N-Me-Phe4,<span style="background-color:#FFFF00">Gly-ol5-enkephalin</span> <span style="background-color:#B0E0E6">binding</span> to <span style="background-color:#FFFF00">mu opioid receptors</span> was significantly higher in the globus pallidus, <span style="background-color:#FFA07A">amygdala</span>, <span style="background-color:#FFA07A">thalamus</span>, hypothalamus, <span style="background-color:#FFA07A">hippocampus</span>, <span style="background-color:#FFA07A">substantia nigra</span>, <span style="background-color:#FFA07A">ventral tegmental area</span>, central gray, and <span style="background-color:#FFDEAD">interpeduncular nucleus</span> of the naltrexone-treated rats.  
 
|-
 
|-
 
|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
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| <span style="color:#800000">'''mu opioid receptors'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">binding</span>) of <span style="color:#800000">'''Gly-ol5-enkephalin'''</span> in <span style="color:#808000">interpeduncular nucleus</span>
+
| <span style="color:#800000">'''mu opioid receptors'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">binding</span>) of <span style="color:#800000">'''Gly-ol5-enkephalin'''</span> in <span style="color:#808000">interpeduncular nucleus</span> associated with <span style="color:#FF0000">'''ventral tegmentum'''</span>, <span style="color:#FF0000">'''substantia nigra'''</span>, <span style="color:#FF0000">'''mu opioid receptor'''</span>, <span style="color:#FF0000">'''enkephalin'''</span>, <span style="color:#FF0000">'''hippocampus'''</span>, <span style="color:#FF0000">'''thalamus'''</span> and <span style="color:#FF0000">'''amygdala'''</span>
 
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=9639282 9639282]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=9639282 9639282]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.71
 
|}
 
|}
 
|-
 
|-
 
|}
 
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{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| As demonstrated using a variety of double labelling techniques (combination of the immunocytochemical detection of Fos with the autoradiography of <span style="background-color:#FFFF00">mu opioid receptors</span>, calbindin immunocytochemistry, in situ <span style="background-color:#B0E0E6">hybridization</span> of <span style="background-color:#FFFF00">preproenkephalin</span> and preprotachykinin A messenger RNAs), striatal <span style="background-color:#FFDEAD">neurons</span> which express Fos are mostly localized in the matrix compartment and concern equally enkephaline and substance P containing efferent neurons.  
+
| As demonstrated using a variety of double labelling techniques (combination of the immunocytochemical detection of Fos with the autoradiography of <span style="background-color:#FFFF00">mu opioid receptors</span>, calbindin immunocytochemistry, in situ <span style="background-color:#B0E0E6">hybridization</span> of <span style="background-color:#FFFF00">preproenkephalin</span> and preprotachykinin A messenger RNAs), striatal <span style="background-color:#FFDEAD">neurons</span> which express Fos are mostly localized in the matrix compartment and concern equally enkephaline and <span style="background-color:#FFA07A">substance P</span> containing efferent neurons.  
 
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|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
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| <span style="color:#800000">'''mu opioid receptors'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">hybridization</span>) of <span style="color:#800000">'''preproenkephalin'''</span> in <span style="color:#808000">neurons</span>
+
| <span style="color:#800000">'''mu opioid receptors'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">hybridization</span>) of <span style="color:#800000">'''preproenkephalin'''</span> in <span style="color:#808000">neurons</span> associated with <span style="color:#FF0000">'''mu opioid receptor'''</span> and <span style="color:#FF0000">'''substance p'''</span>
 
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=9300404 9300404]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=9300404 9300404]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.15
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.20
 
|}
 
|}
 
|-
 
|-
 
|}
 
|}
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| Following naltrexone administration, mu receptor immunoreactivity was significantly higher in the amygdala, thalamus, hippocampus, and interpeduncular nucleus as compared with the saline-treated control animals. [3H]D-Ala2,N-Me-Phe4,<span style="background-color:#FFFF00">Gly-ol5-enkephalin</span> <span style="background-color:#B0E0E6">binding</span> to <span style="background-color:#FFFF00">mu opioid receptors</span> was significantly higher in the globus pallidus, amygdala, thalamus, hypothalamus, hippocampus, substantia nigra, ventral tegmental area, central gray, and <span style="background-color:#FFDEAD">interpeduncular nucleus</span> of the naltrexone-treated rats.  
+
| Following naltrexone administration, mu receptor immunoreactivity was significantly higher in the <span style="background-color:#FFA07A">amygdala</span>, <span style="background-color:#FFA07A">thalamus</span>, <span style="background-color:#FFA07A">hippocampus</span>, and interpeduncular nucleus as compared with the saline-treated control animals. [3H]D-Ala2,N-Me-Phe4,<span style="background-color:#FFFF00">Gly-ol5-enkephalin</span> <span style="background-color:#B0E0E6">binding</span> to <span style="background-color:#FFFF00">mu opioid receptors</span> was significantly higher in the globus pallidus, <span style="background-color:#FFA07A">amygdala</span>, <span style="background-color:#FFA07A">thalamus</span>, hypothalamus, <span style="background-color:#FFA07A">hippocampus</span>, <span style="background-color:#FFA07A">substantia nigra</span>, <span style="background-color:#FFA07A">ventral tegmental area</span>, central gray, and <span style="background-color:#FFDEAD">interpeduncular nucleus</span> of the naltrexone-treated rats.  
 
|-
 
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|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
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| <span style="color:#800000">'''mu opioid receptors'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">binding</span>) of <span style="color:#800000">'''Gly-ol5-enkephalin'''</span> in <span style="color:#808000">interpeduncular nucleus</span>
+
| <span style="color:#800000">'''mu opioid receptors'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">binding</span>) of <span style="color:#800000">'''Gly-ol5-enkephalin'''</span> in <span style="color:#808000">interpeduncular nucleus</span> associated with <span style="color:#FF0000">'''ventral tegmentum'''</span>, <span style="color:#FF0000">'''substantia nigra'''</span>, <span style="color:#FF0000">'''mu opioid receptor'''</span>, <span style="color:#FF0000">'''enkephalin'''</span>, <span style="color:#FF0000">'''hippocampus'''</span>, <span style="color:#FF0000">'''thalamus'''</span> and <span style="color:#FF0000">'''amygdala'''</span>
 
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=9639282 9639282]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=9639282 9639282]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.71
 
|}
 
|}
 
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{| cellpadding=4 cellspacing=2  
 
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| <span style="color:#800000">'''Mu opioid receptors'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">association</span>) of <span style="color:#800000">'''Leu5-enkephalin'''</span> in <span style="color:#808000">nucleus</span>
+
| <span style="color:#800000">'''Mu opioid receptors'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">association</span>) of <span style="color:#800000">'''Leu5-enkephalin'''</span> in <span style="color:#808000">nucleus</span> associated with <span style="color:#FF0000">'''mu opioid receptor'''</span> and <span style="color:#FF0000">'''enkephalin'''</span>
 
|-
 
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=8841907 8841907]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=8841907 8841907]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 1.05
 
|}
 
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|-
 
|-
 
|}
 
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{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| Following naltrexone administration, mu receptor immunoreactivity was significantly higher in the amygdala, thalamus, hippocampus, and interpeduncular nucleus as compared with the saline-treated control animals. [3H]D-Ala2,N-Me-Phe4,<span style="background-color:#FFFF00">Gly-ol5-enkephalin</span> <span style="background-color:#B0E0E6">binding</span> to <span style="background-color:#FFFF00">mu opioid receptors</span> was significantly higher in the globus pallidus, amygdala, thalamus, hypothalamus, hippocampus, substantia nigra, ventral tegmental area, <span style="background-color:#FFDEAD">central gray</span>, and interpeduncular nucleus of the naltrexone-treated rats.  
+
| Following naltrexone administration, mu receptor immunoreactivity was significantly higher in the <span style="background-color:#FFA07A">amygdala</span>, <span style="background-color:#FFA07A">thalamus</span>, <span style="background-color:#FFA07A">hippocampus</span>, and interpeduncular nucleus as compared with the saline-treated control animals. [3H]D-Ala2,N-Me-Phe4,<span style="background-color:#FFFF00">Gly-ol5-enkephalin</span> <span style="background-color:#B0E0E6">binding</span> to <span style="background-color:#FFFF00">mu opioid receptors</span> was significantly higher in the globus pallidus, <span style="background-color:#FFA07A">amygdala</span>, <span style="background-color:#FFA07A">thalamus</span>, hypothalamus, <span style="background-color:#FFA07A">hippocampus</span>, <span style="background-color:#FFA07A">substantia nigra</span>, <span style="background-color:#FFA07A">ventral tegmental area</span>, <span style="background-color:#FFDEAD">central gray</span>, and interpeduncular nucleus of the naltrexone-treated rats.  
 
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|
 
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{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
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| <span style="color:#800000">'''mu opioid receptors'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">binding</span>) of <span style="color:#800000">'''Gly-ol5-enkephalin'''</span> in <span style="color:#808000">central gray</span>
+
| <span style="color:#800000">'''mu opioid receptors'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">binding</span>) of <span style="color:#800000">'''Gly-ol5-enkephalin'''</span> in <span style="color:#808000">central gray</span> associated with <span style="color:#FF0000">'''ventral tegmentum'''</span>, <span style="color:#FF0000">'''substantia nigra'''</span>, <span style="color:#FF0000">'''mu opioid receptor'''</span>, <span style="color:#FF0000">'''enkephalin'''</span>, <span style="color:#FF0000">'''hippocampus'''</span>, <span style="color:#FF0000">'''thalamus'''</span> and <span style="color:#FF0000">'''amygdala'''</span>
 
|-
 
|-
 
|}
 
|}
Line 388: Line 388:
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=9639282 9639282]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=9639282 9639282]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.71
 
|}
 
|}
 
|-
 
|-
 
|}
 
|}
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| Following naltrexone administration, mu receptor immunoreactivity was significantly higher in the amygdala, thalamus, hippocampus, and interpeduncular nucleus as compared with the saline-treated control animals. [3H]D-Ala2,N-Me-Phe4,<span style="background-color:#FFFF00">Gly-ol5-enkephalin</span> <span style="background-color:#B0E0E6">binding</span> to <span style="background-color:#FFFF00">mu opioid receptors</span> was significantly higher in the globus pallidus, amygdala, thalamus, hypothalamus, hippocampus, substantia nigra, ventral tegmental area, <span style="background-color:#FFDEAD">central gray</span>, and interpeduncular nucleus of the naltrexone-treated rats.  
+
| Following naltrexone administration, mu receptor immunoreactivity was significantly higher in the <span style="background-color:#FFA07A">amygdala</span>, <span style="background-color:#FFA07A">thalamus</span>, <span style="background-color:#FFA07A">hippocampus</span>, and interpeduncular nucleus as compared with the saline-treated control animals. [3H]D-Ala2,N-Me-Phe4,<span style="background-color:#FFFF00">Gly-ol5-enkephalin</span> <span style="background-color:#B0E0E6">binding</span> to <span style="background-color:#FFFF00">mu opioid receptors</span> was significantly higher in the globus pallidus, <span style="background-color:#FFA07A">amygdala</span>, <span style="background-color:#FFA07A">thalamus</span>, hypothalamus, <span style="background-color:#FFA07A">hippocampus</span>, <span style="background-color:#FFA07A">substantia nigra</span>, <span style="background-color:#FFA07A">ventral tegmental area</span>, <span style="background-color:#FFDEAD">central gray</span>, and interpeduncular nucleus of the naltrexone-treated rats.  
 
|-
 
|-
 
|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''mu opioid receptors'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">binding</span>) of <span style="color:#800000">'''Gly-ol5-enkephalin'''</span> in <span style="color:#808000">central gray</span>
+
| <span style="color:#800000">'''mu opioid receptors'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">binding</span>) of <span style="color:#800000">'''Gly-ol5-enkephalin'''</span> in <span style="color:#808000">central gray</span> associated with <span style="color:#FF0000">'''ventral tegmentum'''</span>, <span style="color:#FF0000">'''substantia nigra'''</span>, <span style="color:#FF0000">'''mu opioid receptor'''</span>, <span style="color:#FF0000">'''enkephalin'''</span>, <span style="color:#FF0000">'''hippocampus'''</span>, <span style="color:#FF0000">'''thalamus'''</span> and <span style="color:#FF0000">'''amygdala'''</span>
 
|-
 
|-
 
|}
 
|}
Line 419: Line 419:
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=9639282 9639282]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=9639282 9639282]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.71
 
|}
 
|}
 
|-
 
|-

Latest revision as of 12:33, 14 September 2012

Context Info
Confidence 0.39
First Reported 1996
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.15
Pain Relevance 5.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk)
Anatomy Mention Frequency
interpeduncular nucleus 2
central gray 2
dentate gyrus 1
neurons 1
nucleus 1
Penk (Rattus norvegicus)
Pain Term Frequency Confidence Heat
Enkephalin 31 100.00 Very High Very High Very High
mu opioid receptor 46 100.00 Very High Very High Very High
Morphine 2 98.08 Very High Very High Very High
amygdala 8 98.00 Very High Very High Very High
Hippocampus 8 97.92 Very High Very High Very High
Thalamus 8 97.66 Very High Very High Very High
Substantia nigra 4 96.12 Very High Very High Very High
Ventral tegmentum 4 95.40 Very High Very High Very High
agonist 2 95.36 Very High Very High Very High
substance P 1 93.64 High High
Disease Term Frequency Confidence Heat
Shock 2 81.04 Quite High

[edit] Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neurons with mu opioid receptors interact indirectly with enkephalin-containing neurons in the rat dentate gyrus.
mu opioid receptors Binding (interact) of enkephalin in dentate gyrus associated with mu opioid receptor and enkephalin
1) Confidence 0.39 Published 2002 Journal Exp. Neurol. Section Title Doc Link 12093103 Disease Relevance 0 Pain Relevance 0.99
Following naltrexone administration, mu receptor immunoreactivity was significantly higher in the amygdala, thalamus, hippocampus, and interpeduncular nucleus as compared with the saline-treated control animals. [3H]D-Ala2,N-Me-Phe4,Gly-ol5-enkephalin binding to mu opioid receptors was significantly higher in the globus pallidus, amygdala, thalamus, hypothalamus, hippocampus, substantia nigra, ventral tegmental area, central gray, and interpeduncular nucleus of the naltrexone-treated rats.
mu opioid receptors Binding (binding) of Gly-ol5-enkephalin in interpeduncular nucleus associated with ventral tegmentum, substantia nigra, mu opioid receptor, enkephalin, hippocampus, thalamus and amygdala
2) Confidence 0.11 Published 1998 Journal Neuroscience Section Abstract Doc Link 9639282 Disease Relevance 0 Pain Relevance 0.71
As demonstrated using a variety of double labelling techniques (combination of the immunocytochemical detection of Fos with the autoradiography of mu opioid receptors, calbindin immunocytochemistry, in situ hybridization of preproenkephalin and preprotachykinin A messenger RNAs), striatal neurons which express Fos are mostly localized in the matrix compartment and concern equally enkephaline and substance P containing efferent neurons.
mu opioid receptors Binding (hybridization) of preproenkephalin in neurons associated with mu opioid receptor and substance p
3) Confidence 0.11 Published 1997 Journal Neuroscience Section Abstract Doc Link 9300404 Disease Relevance 0.15 Pain Relevance 0.20
Following naltrexone administration, mu receptor immunoreactivity was significantly higher in the amygdala, thalamus, hippocampus, and interpeduncular nucleus as compared with the saline-treated control animals. [3H]D-Ala2,N-Me-Phe4,Gly-ol5-enkephalin binding to mu opioid receptors was significantly higher in the globus pallidus, amygdala, thalamus, hypothalamus, hippocampus, substantia nigra, ventral tegmental area, central gray, and interpeduncular nucleus of the naltrexone-treated rats.
mu opioid receptors Binding (binding) of Gly-ol5-enkephalin in interpeduncular nucleus associated with ventral tegmentum, substantia nigra, mu opioid receptor, enkephalin, hippocampus, thalamus and amygdala
4) Confidence 0.09 Published 1998 Journal Neuroscience Section Abstract Doc Link 9639282 Disease Relevance 0 Pain Relevance 0.71
Immunolabeling of Mu opioid receptors in the rat nucleus of the solitary tract: extrasynaptic plasmalemmal localization and association with Leu5-enkephalin.
Mu opioid receptors Binding (association) of Leu5-enkephalin in nucleus associated with mu opioid receptor and enkephalin
5) Confidence 0.07 Published 1996 Journal J. Comp. Neurol. Section Title Doc Link 8841907 Disease Relevance 0 Pain Relevance 1.05
Following naltrexone administration, mu receptor immunoreactivity was significantly higher in the amygdala, thalamus, hippocampus, and interpeduncular nucleus as compared with the saline-treated control animals. [3H]D-Ala2,N-Me-Phe4,Gly-ol5-enkephalin binding to mu opioid receptors was significantly higher in the globus pallidus, amygdala, thalamus, hypothalamus, hippocampus, substantia nigra, ventral tegmental area, central gray, and interpeduncular nucleus of the naltrexone-treated rats.
mu opioid receptors Binding (binding) of Gly-ol5-enkephalin in central gray associated with ventral tegmentum, substantia nigra, mu opioid receptor, enkephalin, hippocampus, thalamus and amygdala
6) Confidence 0.04 Published 1998 Journal Neuroscience Section Abstract Doc Link 9639282 Disease Relevance 0 Pain Relevance 0.71
Following naltrexone administration, mu receptor immunoreactivity was significantly higher in the amygdala, thalamus, hippocampus, and interpeduncular nucleus as compared with the saline-treated control animals. [3H]D-Ala2,N-Me-Phe4,Gly-ol5-enkephalin binding to mu opioid receptors was significantly higher in the globus pallidus, amygdala, thalamus, hypothalamus, hippocampus, substantia nigra, ventral tegmental area, central gray, and interpeduncular nucleus of the naltrexone-treated rats.
mu opioid receptors Binding (binding) of Gly-ol5-enkephalin in central gray associated with ventral tegmentum, substantia nigra, mu opioid receptor, enkephalin, hippocampus, thalamus and amygdala
7) Confidence 0.03 Published 1998 Journal Neuroscience Section Abstract Doc Link 9639282 Disease Relevance 0 Pain Relevance 0.71

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