INT65055

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Context Info
Confidence 0.58
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 83
Total Number 83
Disease Relevance 44.85
Pain Relevance 34.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nfkb1) DNA binding (Nfkb1) protein complex (Nfkb1)
cytoplasm (Nfkb1) cytosol (Nfkb1) signal transduction (Nfkb1)
Anatomy Link Frequency
macrophages 3
nucleus 2
intestine 2
spinal nerve 1
retina 1
Nfkb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 158 100.00 Very High Very High Very High
cytokine 93 100.00 Very High Very High Very High
COX2 19 100.00 Very High Very High Very High
ketamine 26 99.98 Very High Very High Very High
Morphine 34 99.84 Very High Very High Very High
cINOD 75 99.70 Very High Very High Very High
narcan 12 99.66 Very High Very High Very High
Neuropathic pain 123 99.62 Very High Very High Very High
aspirin 40 99.60 Very High Very High Very High
Spinal cord 43 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 38 99.90 Very High Very High Very High
Apoptosis 155 99.82 Very High Very High Very High
Diabetes Mellitus 17 99.76 Very High Very High Very High
Neuropathic Pain 167 99.62 Very High Very High Very High
INFLAMMATION 198 99.60 Very High Very High Very High
Nervous System Injury 57 99.54 Very High Very High Very High
Pain 68 99.48 Very High Very High Very High
Hypoxia 25 99.36 Very High Very High Very High
Shock 9 99.36 Very High Very High Very High
Cancer 81 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data show that targeted blockade of NF-kappaB activity in spinal glia efficiently alleviates pain behavior in CCI rats, demonstrating the active participation of the glial NF-kappaB pathway in the development of neuropathic pain after peripheral nerve injury.
Negative_regulation (blockade) of NF-kappaB in peripheral nerve associated with pain, nervous system injury, neuropathic pain and peripheral nerve injury
1) Confidence 0.58 Published 2007 Journal Mol. Ther. Section Abstract Doc Link 17299402 Disease Relevance 1.02 Pain Relevance 1.07
We report here that flurbiprofen nitroxybutyl ester inhibits nuclear factor-kappaB (NF-kappaB) activity and cell growth in L929 cells at a concentration of 100 microM, whereas flurbiprofen is inactive.
Negative_regulation (inhibits) of NF-kappaB in L929
2) Confidence 0.58 Published 2003 Journal Antioxid. Redox Signal. Section Abstract Doc Link 12716482 Disease Relevance 0.76 Pain Relevance 0.33
Suppression of NF-kappaB could be a potential new strategy for the treatment of neuropathic pain.


Negative_regulation (Suppression) of NF-kappaB
3) Confidence 0.58 Published 2006 Journal Br J Anaesth Section Body Doc Link 16885169 Disease Relevance 0.19 Pain Relevance 0
Moreover, CCI induced a significant downregulation of nuclear factor kappaB (NF-kappaB) within the ipsilateral spinal cord dorsal horn, which also was attenuated by either RU38486 (4 > 2 = 0.5 microg = vehicle) or a GR antisense oligonucleotide.
Negative_regulation (downregulation) of NF-kappaB in spinal cord dorsal horn associated with nervous system injury, dorsal horn and spinal cord
4) Confidence 0.57 Published 2006 Journal Pain Section Abstract Doc Link 16360273 Disease Relevance 0.69 Pain Relevance 0.59
The elevated TNFalpha, IL-1beta and NF-kappaB in brain were accordingly reduced, while the expression of increased IL-10 were even stimulated after repeated mirtazapine administration.
Negative_regulation (reduced) of NF-kappaB in brain
5) Confidence 0.56 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18248895 Disease Relevance 0.67 Pain Relevance 0.98
IL-1beta caused a rapid increase in phosphorylated IkappaB-alpha levels and subsequent transient decrease in IkappaB-alpha levels, an inhibitor of NF-kappaB, as revealed by Western blot analysis using specific antibodies for phosphorylated and nonphosphorylated IkappaB-alpha.
Negative_regulation (inhibitor) of NF-kappaB
6) Confidence 0.48 Published 1999 Journal Endocrinology Section Abstract Doc Link 10218970 Disease Relevance 0.30 Pain Relevance 0.70
These effects seem to be independent of NF-kappaB inhibition.
Negative_regulation (inhibition) of NF-kappaB
7) Confidence 0.48 Published 2005 Journal Hypertension Section Abstract Doc Link 15851630 Disease Relevance 0.81 Pain Relevance 0.18
CONCLUSION: Ketamine suppresses the production of proinflammatory cytokines such as TNF-alpha and IL-6 in the intestine, possibly via inhibition of NF-kappaB.


Negative_regulation (inhibition) of NF-kappaB in intestine
8) Confidence 0.47 Published 2004 Journal Acta Anaesthesiol Scand Section Body Doc Link 14982564 Disease Relevance 0 Pain Relevance 0
Salicylates, in doses administrated in our experiments, inhibited NF-kappaB and perhaps other transcription factors in the retina, were well tolerated, and offered new tools to investigate and inhibit the development of diabetic retinopathy.
Negative_regulation (inhibited) of NF-kappaB in retina associated with diabetic retinopathy
9) Confidence 0.47 Published 2007 Journal Diabetes Section Abstract Doc Link 17259377 Disease Relevance 1.12 Pain Relevance 0.15
These three drugs differ in their ability to inhibit cyclooxygenase but share an ability to inhibit nuclear factor-kappaB (NF-kappaB).
Negative_regulation (inhibit) of NF-kappaB
10) Confidence 0.47 Published 2007 Journal Diabetes Section Abstract Doc Link 17259377 Disease Relevance 1.08 Pain Relevance 0.28
There is a broad consensus that glucocorticoids (GCs) exert anti-inflammatory effects largely by inhibiting the function of nuclear factor kappaB (NFkappaB) and consequently the transcription of pro-inflammatory genes.
Negative_regulation (inhibiting) of NFkappaB associated with inflammation
11) Confidence 0.45 Published 2007 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 17561338 Disease Relevance 0.27 Pain Relevance 0.14
Hence, novel GC-related drugs that mediate inhibition of NFkappaB but do not activate gene expression are predicted to retain therapeutic effects but cause fewer or less severe side effects.
Negative_regulation (inhibition) of NFkappaB
12) Confidence 0.45 Published 2007 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 17561338 Disease Relevance 0.46 Pain Relevance 0.28
Moreover, this compound reduces the increased NF-kappaB binding activity, which occurs in these degenerative conditions.
Negative_regulation (reduces) of NF-kappaB
13) Confidence 0.43 Published 2002 Journal Neurochem. Int. Section Abstract Doc Link 11918971 Disease Relevance 1.22 Pain Relevance 0.62
Lentiviral-mediated targeted NF-kappaB blockade in dorsal spinal cord glia attenuates sciatic nerve injury-induced neuropathic pain in the rat.
Negative_regulation (blockade) of NF-kappaB in dorsal associated with neuralgia, nervous system injury, neuropathic pain, sciatic nerve and spinal cord
14) Confidence 0.43 Published 2007 Journal Mol. Ther. Section Title Doc Link 17299402 Disease Relevance 0.82 Pain Relevance 1.21
Acetaminophen protects hippocampal neurons and PC12 cultures from amyloid beta-peptides induced oxidative stress and reduces NF-kappaB activation.
Negative_regulation (reduces) of NF-kappaB in neurons associated with stress, paracetamol and alzheimer's dementia
15) Confidence 0.43 Published 2002 Journal Neurochem. Int. Section Title Doc Link 11918971 Disease Relevance 1.38 Pain Relevance 0.65
We also used pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF kappa B, before 1 h of hypoxia to establish the possible role of NF kappa B in modulating myocardial angiogenesis.
Negative_regulation (inhibitor) of NF kappa B associated with hypoxia
16) Confidence 0.43 Published 2000 Journal Int J Tissue React Section Abstract Doc Link 11199341 Disease Relevance 0.57 Pain Relevance 0.08
To study its role in chronic pain, it is thus essential to inhibit the NF-kappaB pathway selectively in activated spinal glial cells.
Negative_regulation (inhibit) of NF-kappaB in glial cells associated with lasting pain
17) Confidence 0.43 Published 2007 Journal Mol. Ther. Section Abstract Doc Link 17299402 Disease Relevance 0.87 Pain Relevance 1.00
Here, we show that when restricted to spinal cord and targeted to glial cells, lentiviral vector-mediated delivery of NF-kappaB super- repressor IkappaBalpha resulted in an inhibition of the NF-kappaB pathway activated in the rat spinal cord after sciatic nerve injury (chronic constriction injury, CCI).
Negative_regulation (inhibition) of NF-kappaB in spinal cord associated with nervous system injury, eae, injury, sciatic nerve and spinal cord
18) Confidence 0.43 Published 2007 Journal Mol. Ther. Section Abstract Doc Link 17299402 Disease Relevance 0.94 Pain Relevance 1.14
However inhibition of NF kappa B by PDTC decreased capillary density significantly when compared with the hypoxic group.
Negative_regulation (inhibition) of NF kappa B in capillary associated with hypoxia
19) Confidence 0.42 Published 2000 Journal Int J Tissue React Section Abstract Doc Link 11199341 Disease Relevance 0.64 Pain Relevance 0.06
Inhibition of NF kappa B activation by pyrrolidine dithiocarbamate prevents in vivo hypoxia/reoxygenation-mediated myocardial angiogenesis.
Negative_regulation (Inhibition) of NF kappa B associated with hypoxia
20) Confidence 0.42 Published 2000 Journal Int J Tissue React Section Title Doc Link 11199341 Disease Relevance 0.53 Pain Relevance 0.09

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