INT65069

Context Info Confidence 0.02 First Reported 1996 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 5 Disease Relevance 0.92 Pain Relevance 1.21

nucleus (SHOX)

Anatomy Link Frequency plasma 1 SHOX (Homo sapiens)

Pain Link Frequency Relevance Heat Somatostatin 8 100.00 electroacupuncture 9 98.20 Pain 19 97.36 narcan 3 94.24 Acupuncture 7 89.24 opiate 2 39.20 imagery 9 5.00 carpal tunnel syndrome 8 5.00 cINOD 3 5.00 addiction 3 5.00

Disease Link Frequency Relevance Heat Volume Depletion And Dehydration 33 99.76 Pain 20 97.36 Carpal Tunnel Syndrome 22 90.80 Sprains And Strains 6 83.92 Hypoxia 30 60.08 Stress 9 6.80 Disease 33 5.00 Sickle Cell Anemia 12 5.00 Hemolytic Anemia 6 5.00 Increased Venous Pressure Under Development 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The cell age-dependent heterogeneity of Gardos channel activity in AA cells [48] likely also increases the heterogeneity of deoxygenation-induced SS cell dehydration.

Positive_regulation (induced) of SS associated with volume depletion and dehydration

1) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806905 Disease Relevance 0.36 Pain Relevance 0

Deoxygenation nonetheless increases human SS cell permeability to many low molecular weight solutes [51], suggesting that deoxygenation either regulates multiple transport pathways or one or more pathways of unusually low selectivity.

Positive_regulation (increases) of SS

2) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806905 Disease Relevance 0.06 Pain Relevance 0

Since the proximate pathological consequence of Psickle activation is believed to be elevation of SS cell [Ca2+]i, we monitored Fluo-3 fluorescence emission during deoxygenation in SAD cells.

Positive_regulation (elevation) of SS

3) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806905 Disease Relevance 0.08 Pain Relevance 0

The interval measurements (CTSI-JSSH-SS, CTSI-JSSH-FS, DASH-JSSH, SF-36-BP, age) were normally distributed and the other interval measurements (SF-36-PF, SF-36-RP, VAS for pain, and time required to fill out the questionnaire of the CTSI-JSSH) were not normally distributed.

Positive_regulation (distributed) of CTSI-JSSH-SS associated with pain

4) Confidence 0.01 Published 2007 Journal J Orthop Sci Section Body Doc Link PMC2778629 Disease Relevance 0.41 Pain Relevance 0.26

EAP significantly inhibited acid secretion (75%; P < 0.01), which coincided with significant increases in plasma SS, VIP, and beta-endorphin and a significant decrease in plasma gastrin.

Positive_regulation (increases) of SS in plasma associated with somatostatin and electroacupuncture

5) Confidence 0.01 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8843779 Disease Relevance 0 Pain Relevance 0.95

General Comments

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