INT65089

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Context Info
Confidence 0.50
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.67
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ACP5) small molecule metabolic process (ACP5) lysosome (ACP5)
Anatomy Link Frequency
osteoclasts 1
ACP5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 7 99.32 Very High Very High Very High
Clonidine 1 97.44 Very High Very High Very High
cOX1 2 97.00 Very High Very High Very High
Inflammation 6 78.36 Quite High
cva 1 75.24 Quite High
Pain 5 52.16 Quite High
Central nervous system 1 36.80 Quite Low
Osteoarthritis 39 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gauchers Disease 30 99.68 Very High Very High Very High
Spontaneous Fractures 6 95.56 Very High Very High Very High
Disease Progression 1 95.20 Very High Very High Very High
Necrosis 9 94.00 High High
Neurological Disease 1 83.76 Quite High
INFLAMMATION 10 78.36 Quite High
Hemorrhage 1 75.24 Quite High
Fracture Healing 64 73.64 Quite High
Gallstones 1 60.48 Quite High
Anaemia 1 57.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Catecholamines also reduced cell proliferation, increased tartrate-resistant acid phosphatase (TRAcP) activity, interleukin 6 (IL-6) production, multi-nuclearity and response to salmon calcitonin (sCT) in undifferentiated FLG 29.1 cells.
Positive_regulation (increased) of tartrate-resistant acid phosphatase associated with catecholamine
1) Confidence 0.50 Published 1996 Journal Osteoporos Int Section Abstract Doc Link 8845594 Disease Relevance 0 Pain Relevance 0.39
Several biomarkers (chitotriosidase, ferritin, angiotensin-converting enzyme (ACE) and tartrate-resistant acid phosphatase (TRAP)) are elevated during GD evolution [9-16].
Positive_regulation (elevated) of tartrate-resistant acid phosphatase associated with gauchers disease
2) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945057 Disease Relevance 1.13 Pain Relevance 0.05
This analysis revealed statistically significant differential expression for only three genes; tartrate resistant acid phosphatase 5 (ACP5) increased by a fold change of 10.60 (5 to 53 ESTs), cytochrome c oxidase subunit I (COX1) increased by a fold change of 2.1 (87 to 178 ESTs), and perlecan decreased by a fold change of 3.9 (31 to 8 ESTs).
Positive_regulation (increased) of ACP5 associated with cox1
3) Confidence 0.13 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1578570 Disease Relevance 0.55 Pain Relevance 0.13
At the end of the incubation period, the osteoclasts were fixed with citrate/acetone solution and stained for tartrate-resistant acid phosphatase (TRAP) according to the manufacturer's recommendation (Sigma-Aldrich).
Positive_regulation (stained) of tartrate-resistant acid phosphatase in osteoclasts
4) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483463 Disease Relevance 0 Pain Relevance 0

General Comments

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