INT65154

Context Info Confidence 0.34 First Reported 1995 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 5 Disease Relevance 1.37 Pain Relevance 0.84

endosome (HLA-DPB1) Golgi apparatus (HLA-DPB1) endoplasmic reticulum (HLA-DPB1) plasma membrane (HLA-DPB1)

Anatomy Link Frequency T-helper cells 1 HLA-DPB1 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 7 99.76 spinal inflammation 4 75.00 Inflammation 1 75.00

Disease Link Frequency Relevance Heat Cancer 9 100.00 Iridocyclitis 3 98.04 Low Back Pain 4 75.00 Colon Cancer 3 75.00 INFLAMMATION 1 75.00 Disease 4 32.32 Autoimmune Disease 5 29.68 Diabetes Mellitus 1 26.72 Celiac Disease 1 23.76 Disease Susceptibility 1 15.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This result is explained by the high recombination region involving one or several hotspots, which separates HLA-DPB1 from the rest of the other HLA loci.

Positive_regulation (separates) of HLA-DPB1

1) Confidence 0.34 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2883542 Disease Relevance 0 Pain Relevance 0

The increase of DRB1*08 and DPB1*0301 was due to an increase of DRB1*08 and DPB1*0301 in combination, whereas the association with B*4001 could be due to linkage disequilibrium with LMP2b.

Positive_regulation (increase) of DPB1

2) Confidence 0.32 Published 1995 Journal Hum. Immunol. Section Abstract Doc Link 8847233 Disease Relevance 0.17 Pain Relevance 0.07

We found an increase of the B*4001, DRB1*08, and DPB1*0301 alleles, as well as the LMP2 b/b genotype (the latter was most pronounced among patients with acute iridocyclitis), in JAS compared to B27-positive controls.

Positive_regulation (increase) of DPB1 associated with iridocyclitis

3) Confidence 0.28 Published 1995 Journal Hum. Immunol. Section Abstract Doc Link 8847233 Disease Relevance 0.17 Pain Relevance 0.07

The increase of DRB1*08 and DPB1*0301 was due to an increase of DRB1*08 and DPB1*0301 in combination, whereas the association with B*4001 could be due to linkage disequilibrium with LMP2b.

Positive_regulation (increase) of DPB1

4) Confidence 0.21 Published 1995 Journal Hum. Immunol. Section Abstract Doc Link 8847233 Disease Relevance 0.17 Pain Relevance 0.07

MHC II protein (HLA-DP, -DQ, -DR) levels and infiltration by CD4+ T-helper cells of tumor stroma increased upon NSAID treatment, while CD8+ cytotoxic T-lymphocytes increased in both tumor stroma and epithelium.

Positive_regulation (increased) of HLA-DP in T-helper cells associated with cancer and cinod

5) Confidence 0.03 Published 2008 Journal Cancer Immun. Section Abstract Doc Link 18307280 Disease Relevance 0.85 Pain Relevance 0.61

General Comments

This test has worked.