INT65190

Context Info Confidence 0.44 First Reported 1996 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.51 Pain Relevance 1.26

extracellular space (Umod) extracellular region (Umod) Golgi apparatus (Umod) cytoplasmic membrane-bounded vesicle (Umod) plasma membrane (Umod)

Anatomy Link Frequency tail 1 Umod (Rattus norvegicus)

Pain Link Frequency Relevance Heat Antinociceptive 1 99.98 antagonist 2 99.40 tail-flick 5 98.52 Spinal cord 8 95.40 Pain 4 89.88 Neurotransmitter 1 87.96 Pain threshold 2 80.08 Intracerebroventricular 1 73.76 GABAergic 1 73.68 Analgesic 1 68.40

Disease Link Frequency Relevance Heat Pain 6 89.88 Nociception 1 69.76 Anxiety Disorder 1 67.36 Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The alkaloid strychnine, well-known as a glycine receptor (Gly-R) antagonist, blocked glycine stimulatory effect on 3alpha,5alpha-THP formation.

Regulation (effect) of THP associated with antagonist

1) Confidence 0.44 Published 2008 Journal Neuroscience Section Abstract Doc Link 18367344 Disease Relevance 0.07 Pain Relevance 0.52

In particular, EB potentiated the antinociceptive effect of THP and DHP by significantly increasing tail-flick latencies above those of non-EB-treated animals.

Regulation (effect) of THP in tail associated with tail-flick and antinociceptive

2) Confidence 0.08 Published 1996 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 8848456 Disease Relevance 0.44 Pain Relevance 0.75

General Comments

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