INT65459

Context Info Confidence 0.07 First Reported 1996 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 9 Total Number 9 Disease Relevance 4.57 Pain Relevance 2.28

cell differentiation (Racgap1) transport (Racgap1) intracellular (Racgap1) embryo development (Racgap1) cytoplasm (Racgap1) signal transduction (Racgap1)

Anatomy Link Frequency photoreceptors 1 tail 1 platelet 1 Racgap1 (Mus musculus)

Pain Link Frequency Relevance Heat agonist 15 100.00 5HT 23 99.54 opioid receptor 8 99.02 ischemia 174 97.92 sSRI 5 97.48 Neurotransmitter 5 96.60 Calcium channel 1 90.96 sodium channel 7 90.28 Multiple sclerosis 82 85.20 cannabis 1 82.32

Disease Link Frequency Relevance Heat Stress 61 99.78 Reperfusion Injury 12 98.68 Cv Unclassified Under Development 62 97.92 Hypothermia 14 94.28 Traumatic Stress Disorders 1 90.80 Disease 38 88.20 Hemorrhage 2 87.92 Multiple Sclerosis 93 85.20 Cv General 4 Under Development 110 84.52 Cognitive Disorder 27 83.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, a peptide designated i4, which was derived from a juxtamembranous region of the carboxyl-terminal tail of the delta-opioid receptor, failed to alter agonist-mediated high affinity GTPase activity or agonist-driven [35S]guanosine 5'-O-thiotriphosphate binding.

GTPase Binding (binding) of in tail associated with agonist and opioid receptor

1) Confidence 0.07 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8863845 Disease Relevance 0.15 Pain Relevance 0.55

Dynamin monomers are 100KD polypeptides containing 5 functional domains: a GTPase domain that binds and hydrolyses GTP, a middle domain that is involved in oligomerization, a GTPase effector domain (GED) that is involved in oligomerization and stimulation of GTPase activity, and plextrin-homology (PH) and proline-rich (PRD) domains that mediate lipid- and protein-protein interactions.

GTPase Binding (binds) of

2) Confidence 0.06 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2916854 Disease Relevance 0.06 Pain Relevance 0.05

Dynamin monomers are 100KD polypeptides containing 5 functional domains: a GTPase domain that binds and hydrolyses GTP, a middle domain that is involved in oligomerization, a GTPase effector domain (GED) that is involved in oligomerization and stimulation of GTPase activity, and plextrin-homology (PH) and proline-rich (PRD) domains that mediate lipid- and protein-protein interactions.

GTPase Binding (binds) of

3) Confidence 0.06 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2916854 Disease Relevance 0.16 Pain Relevance 0.05

In fact, many shared genes are readily identified as being immune related, such as immunity related GTPase, very large Ifn inducible GTPase, IL1?

GTPase Binding (immunity) of

4) Confidence 0.04 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2939656 Disease Relevance 0.42 Pain Relevance 0.18

Furthermore, deletion of Rac1 GTPase in mouse rod photoreceptors via a Cre/Lox approach has been shown to strongly protect rod photoreceptors against photo-oxidative stress [27].

GTPase Binding (deletion) of in photoreceptors associated with stress

5) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 1.40 Pain Relevance 0.33

The decrease in oxidative stress following Rac GTPase inhibition is likely due to a correlated significant attenuation of O2?

Rac GTPase Neg (inhibition) Binding (inhibition) of associated with stress

6) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 1.46 Pain Relevance 0.35

Rrad encodes a small GTPase that binds to calmodulin and CaM Kinase II [31].

GTPase Binding (binds) of

7) Confidence 0.03 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2216081 Disease Relevance 0.06 Pain Relevance 0.05

A recent study shows that lamin B functions in mitotic spindle assembly through a process that involves the GTP bound form of the small GTPase Ran.

GTPase Binding (bound) of

8) Confidence 0.02 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2745153 Disease Relevance 0.07 Pain Relevance 0

It was recently shown that 5HT can become covalently bound to a number of proteins, a process termed seritonylation, including to small GTPase's, with roles at the vessel wall [272] and in platelet activation [273].

GTPase Binding (bound) of in platelet associated with 5ht

9) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2829540 Disease Relevance 0.79 Pain Relevance 0.73

General Comments

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