INT65553

Context Info Confidence 0.27 First Reported 1996 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 6 Total Number 6 Disease Relevance 3.89 Pain Relevance 1.37

hydrolase activity, acting on glycosyl bonds (Hpse) extracellular region (Hpse) cell adhesion (Hpse) proteinaceous extracellular matrix (Hpse) nucleus (Hpse) carbohydrate metabolic process (Hpse)

Anatomy Link Frequency lymph node 1 Mouse 1 skin 1 Hpse (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 5 99.70 Inflammation 12 98.60 Morphine 11 93.48 cINOD 3 86.40 Central nervous system 1 75.00 anesthesia 2 65.08 Eae 4 58.20 Multiple sclerosis 3 44.12 drug abuse 1 40.44 Pain 6 5.00

Disease Link Frequency Relevance Heat Alopecia Areata 16 100.00 Stress 27 99.58 Targeted Disruption 10 99.32 Autoimmune Disease 1 99.32 INFLAMMATION 13 98.60 Metastasis 2 97.24 Cancer 4 96.84 Necrosis 2 85.52 Body Weight 1 77.04 Wound Healing 3 75.00

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Speculation

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Clinically, up-regulation of heparanase mRNA and protein expression has been documented in a variety of primary human tumors, correlating with reduced postoperative survival and increased lymph node and distant metastasis, thus providing strong clinical support for the prometastatic feature of the enzyme and making it an attractive target for the development of anticancer and anti-inflammatory drugs.

Regulation (regulation) of heparanase in lymph node associated with inflammation, cancer, cinod and metastasis

1) Confidence 0.27 Published 2007 Journal FASEB J. Section Abstract Doc Link 17628014 Disease Relevance 0.65 Pain Relevance 0.14

In fact, our studies have highlighted the heparanase enzyme as a major target for future drug development.

Regulation (target) of heparanase enzyme

2) Confidence 0.27 Published 1998 Journal Immunol. Cell Biol. Section Abstract Doc Link 9553782 Disease Relevance 0.52 Pain Relevance 0.33

Stress further exacerbated changes in AA mouse HPA activity both centrally and peripherally.

Regulation (changes) of HPA associated with stress and alopecia areata

3) Confidence 0.22 Published 2009 Journal J. Invest. Dermatol. Section Abstract Doc Link 19020552 Disease Relevance 1.11 Pain Relevance 0.10

We submit that the dysregulation of the HPA system in these transgenic mice influences the enhanced vulnerability to drug-seeking behavior.

Regulation (dysregulation) of HPA associated with targeted disruption

4) Confidence 0.19 Published 1996 Journal J. Neuroendocrinol. Section Abstract Doc Link 8868255 Disease Relevance 0.64 Pain Relevance 0.70

The positive correlation of HPA hormone levels with skin Th1 cytokines suggests that altered HPA activity may occur as a consequence of the immune response associated with AA.

Regulation (altered) of HPA in skin associated with alopecia areata and cytokine

5) Confidence 0.15 Published 2009 Journal J. Invest. Dermatol. Section Abstract Doc Link 19020552 Disease Relevance 0.89 Pain Relevance 0.10

Mouse HPA reactivity during the first week of life is constantly down regulated [29].

Regulation (regulated) of HPA in Mouse

6) Confidence 0.10 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2000350 Disease Relevance 0.08 Pain Relevance 0

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