INT65589

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Context Info
Confidence 0.58
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.22
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MBTPS1) Golgi apparatus (MBTPS1) endoplasmic reticulum (MBTPS1)
lipid metabolic process (MBTPS1)
Anatomy Link Frequency
leukocyte 1
cleavage 1
MBTPS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 4 99.46 Very High Very High Very High
substance P 3 97.42 Very High Very High Very High
bradykinin 3 91.16 High High
Neuropeptide 1 90.12 High High
Inflammation 28 80.32 Quite High
Analgesic 2 68.56 Quite High
Osteoarthritis 1 66.72 Quite High
metalloproteinase 2 55.28 Quite High
agonist 2 50.00 Quite Low
rheumatoid arthritis 3 40.88 Quite Low
Disease Link Frequency Relevance Heat
Hypophosphatemia 5 89.44 High High
Natriuresis 2 84.96 Quite High
Osteoporosis 1 83.56 Quite High
Cancer 3 81.20 Quite High
INFLAMMATION 32 80.32 Quite High
Nociception 2 76.80 Quite High
Hypertension 2 66.96 Quite High
Osteoarthritis 1 66.72 Quite High
Adhesions 2 61.36 Quite High
Rheumatoid Arthritis 3 40.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neutral endopeptidase is a mammalian type II integral membrane zinc-containing endopeptidase, which degrades and inactivates a number of bioactive peptides.
Protein_catabolism (degrades) of endopeptidase
1) Confidence 0.58 Published 2000 Journal J. Mol. Biol. Section Abstract Doc Link 10669592 Disease Relevance 0.23 Pain Relevance 0.27
Neutral endopeptidase is a mammalian type II integral membrane zinc-containing endopeptidase, which degrades and inactivates a number of bioactive peptides.
Protein_catabolism (degrades) of endopeptidase
2) Confidence 0.43 Published 2000 Journal J. Mol. Biol. Section Abstract Doc Link 10669592 Disease Relevance 0.23 Pain Relevance 0.27
A succinct list of the interesting genes affected by both AnxA1 and Ac2-26 would include SGPP2 (sphingosine-1-phosphate phosphatase), an enzyme involved in the degradation of sphingosine-1-phosphate (S1P), a lipid mediator involved in several physiological processes including cell growth and survival, and leukocyte migration [19], [20].
Protein_catabolism (degradation) of S1P in leukocyte
3) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.41 Pain Relevance 0.11
Angiotensin I, dynorphins 1-8 and 1-9 and substance P also behaved as good substrates while neuromedin N, angiotensin II, leucine and methionine enkephalin and neurokinin A resisted degradation by human endopeptidase 3.4.24.16.
Protein_catabolism (degradation) of endopeptidase associated with enkephalin and substance p
4) Confidence 0.26 Published 1996 Journal Brain Res. Section Abstract Doc Link 8869556 Disease Relevance 0 Pain Relevance 0.24
In contrast, rPhex-WT did display an EDTA-dependent cleavage of the neutral endopeptidase substrate [Leu]enkephalin.
Protein_catabolism (cleavage) of endopeptidase in cleavage associated with enkephalin
5) Confidence 0.17 Published 2001 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 11551862 Disease Relevance 0.35 Pain Relevance 0.10

General Comments

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