INT65724

Context Info Confidence 0.33 First Reported 1996 Last Reported 2000 Negated 0 Speculated 0 Reported most in Abstract Documents 8 Total Number 9 Disease Relevance 2.94 Pain Relevance 8.82

signal transduction (Oprl1) extracellular region (Pnoc) plasma membrane (Oprl1) signal transducer activity (Oprl1)

Anatomy Link Frequency spinal cord 1 Pnoc (Mus musculus) Oprl1 (Mus musculus)

Pain Link Frequency Relevance Heat orphanin 30 100.00 Opioid 29 100.00 opioid receptor 12 100.00 Neuropeptide 11 100.00 allodynia 13 99.20 Hyperalgesia 11 99.20 Pain 19 98.76 Spinal cord 8 95.88 Lasting pain 1 95.04 Intracerebroventricular 2 87.76

Disease Link Frequency Relevance Heat Neuropathic Pain 13 99.20 Hyperalgesia 11 99.20 Pain 17 98.76 Injury 1 93.92 Stress 6 80.16 Nociception 10 73.20 INFLAMMATION 2 25.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Orphanin FQ (OFQ) is the recently isolated endogenous ligand for the orphan opioid-like receptor, LC132.

Orphanin FQ Binding (ligand) of LC132 associated with orphanin and opioid

1) Confidence 0.33 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8878101 Disease Relevance 0.18 Pain Relevance 0.99

Orphanin FQ (OFQ) is the recently isolated endogenous ligand for the orphan opioid-like receptor, LC132.

OFQ Binding (ligand) of LC132 associated with orphanin and opioid

2) Confidence 0.33 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8878101 Disease Relevance 0.18 Pain Relevance 0.99

Orphanin FQ (OFQ), the endogenous ligand for the orphan opioid receptor, LC132, was recently isolated and characterized.

OFQ Binding (ligand) of LC132 associated with orphanin and opioid receptor

3) Confidence 0.27 Published 1996 Journal Neuroreport Section Abstract Doc Link 8930972 Disease Relevance 0.23 Pain Relevance 0.95

Orphanin FQ (OFQ), the endogenous ligand for the orphan opioid receptor, LC132, was recently isolated and characterized.

Orphanin FQ Binding (ligand) of LC132 associated with orphanin and opioid receptor

4) Confidence 0.27 Published 1996 Journal Neuroreport Section Abstract Doc Link 8930972 Disease Relevance 0.23 Pain Relevance 0.95

The neuropeptide nociceptin, also known as orphanin FQ, is an endogenous ligand for the orphan opioid-like receptor which induces both hyperalgesia and allodynia when administered by injection through the theca of the spinal cord into the subarachnoid space (that is, intrathecally).

nociceptin Binding (ligand) of orphan opioid-like receptor in spinal cord associated with hyperalgesia, allodynia, orphanin, neuropeptide, opioid and spinal cord

5) Confidence 0.27 Published 1998 Journal Nature Section Abstract Doc Link 9521323 Disease Relevance 1.03 Pain Relevance 1.35

Its presence was expected by analysis of the precursor for the neuropeptide nociceptin or orphanin FQ (Noc/OFQ), previously identified as an endogenous ligand for the orphan opioid receptor-like receptor.

orphanin FQ Binding (ligand) of orphan opioid receptor-like receptor associated with orphanin, neuropeptide and opioid receptor

6) Confidence 0.15 Published 2000 Journal Peptides Section Abstract Doc Link 10998544 Disease Relevance 0.37 Pain Relevance 0.85

Its presence was expected by analysis of the precursor for the neuropeptide nociceptin or orphanin FQ (Noc/OFQ), previously identified as an endogenous ligand for the orphan opioid receptor-like receptor.

neuropeptide nociceptin Binding (ligand) of orphan opioid receptor-like receptor associated with orphanin, neuropeptide and opioid receptor

7) Confidence 0.15 Published 2000 Journal Peptides Section Abstract Doc Link 10998544 Disease Relevance 0.37 Pain Relevance 0.85

Orphanin FQ (OFQ) is the recently isolated endogenous ligand for the orphan opioid-like receptor, LC132.

OFQ Binding (ligand) of orphan opioid-like receptor associated with orphanin and opioid

8) Confidence 0.13 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8878101 Disease Relevance 0.18 Pain Relevance 0.94

Orphanin FQ (OFQ) is the recently isolated endogenous ligand for the orphan opioid-like receptor, LC132.

Orphanin FQ Binding (ligand) of orphan opioid-like receptor associated with orphanin and opioid

9) Confidence 0.13 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8878101 Disease Relevance 0.18 Pain Relevance 0.94

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