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Context Info
Confidence 0.47
First Reported 1983
Last Reported 2009
Negated 4
Speculated 2
Reported most in Abstract
Documents 18
Total Number 23
Disease Relevance 9.19
Pain Relevance 5.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Alox5) nuclear envelope (Alox5) oxidoreductase activity (Alox5)
nucleus (Alox5) cytoplasm (Alox5)
Anatomy Link Frequency
macrophage 1
pancreatic islet 1
platelets 1
microglia 1
hippocampus 1
Alox5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 113 100.00 Very High Very High Very High
cINOD 21 100.00 Very High Very High Very High
aspirin 13 99.92 Very High Very High Very High
IPN 2 99.36 Very High Very High Very High
diclofenac 5 98.24 Very High Very High Very High
agonist 7 97.32 Very High Very High Very High
Clonidine 7 97.00 Very High Very High Very High
Analgesic 5 96.88 Very High Very High Very High
antagonist 4 96.04 Very High Very High Very High
Hippocampus 4 94.80 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 152 100.00 Very High Very High Very High
Cancer 11 100.00 Very High Very High Very High
Inflammatory Pain 2 99.36 Very High Very High Very High
Congenital Anomalies 6 98.88 Very High Very High Very High
Increased Venous Pressure Under Development 5 98.76 Very High Very High Very High
Nociception 2 98.76 Very High Very High Very High
Diabetes Mellitus 12 98.20 Very High Very High Very High
Arthus Reaction 2 97.20 Very High Very High Very High
Injury 88 96.68 Very High Very High Very High
Disease 18 93.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Differential effects of anti-inflammatory drugs on lipoxygenase and cyclo-oxygenase activities of neutrophils from a reverse passive Arthus reaction.
Regulation (effects) of lipoxygenase in neutrophils associated with inflammation, cinod and arthus reaction
1) Confidence 0.47 Published 1983 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 6221723 Disease Relevance 0.35 Pain Relevance 0.16
Diclofenac sodium, a compound of this class of drugs, appears to have a dual effect since it also regulates the lipoxygenase pathway.
Regulation (regulates) of lipoxygenase associated with diclofenac
2) Confidence 0.40 Published 1986 Journal Am. J. Med. Section Abstract Doc Link 3085488 Disease Relevance 0.26 Pain Relevance 0.34
To evaluate the regulation and effects of pancreatic islet lipoxygenase, adult rat islets were permeabilized, using digitonin or staphylococcal alpha-toxin, and then were studied in a medium simulating an intracellular milieu at fixed ambient concentrations of Ca2+.
Regulation (regulation) of lipoxygenase in pancreatic islet
3) Confidence 0.35 Published 1989 Journal Biochem. Pharmacol. Section Abstract Doc Link 2567595 Disease Relevance 0 Pain Relevance 0.04
The effects of phenolic dental medicaments on lipoxygenase activities of rat dental pulp and human platelets were studied.
Regulation (effects) of lipoxygenase in platelets
4) Confidence 0.31 Published 1990 Journal Dent Jpn (Tokyo) Section Abstract Doc Link 2129162 Disease Relevance 0 Pain Relevance 0
The importance of cyclooxygenase and lipoxygenase pathways in the determination of collagen abnormalities in diabetes was investigated.
Regulation (importance) of lipoxygenase associated with diabetes mellitus and congenital anomalies
5) Confidence 0.26 Published 1985 Journal Diabetes Section Abstract Doc Link 3917259 Disease Relevance 0.76 Pain Relevance 0.12
The effects of cyclooxygenase and lipoxygenase inhibitors on the collagen abnormalities of diabetic rats.
Regulation (effects) of lipoxygenase associated with aspirin, diabetes mellitus and congenital anomalies
6) Confidence 0.22 Published 1985 Journal Diabetes Section Title Doc Link 3917259 Disease Relevance 0.87 Pain Relevance 0.18
These observations indicate that 5-LOX protein is up regulated mainly in microglia/macrophage and neurons in the ipsilateral hemisphere after IR injury.


Regulation (regulated) of 5-LOX protein in microglia associated with injury
7) Confidence 0.20 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1526713 Disease Relevance 0.57 Pain Relevance 0.06
Also investigated was the modulating effect of this agent on the colonic mucosal and tumor phospholipase A2, phosphatidylinositol-specific phospholipase C, lipoxygenase, and cyclooxygenase activities.
Regulation (effect) of lipoxygenase associated with cancer
8) Confidence 0.20 Published 1995 Journal Cancer Res. Section Abstract Doc Link 7882354 Disease Relevance 0.58 Pain Relevance 0.21
Overall, our results from the Fos-LI and behavior tests suggest that LO products released from inflamed tissues contribute to nociception during carrageenan-induced inflammation, indicating that the LO pathway is a possible target for modulating inflammatory pain.
Spec (possible) Regulation (target) of LO associated with nociception, inflammation and ipn
9) Confidence 0.19 Published 2009 Journal Mol. Cells Section Abstract Doc Link 19390822 Disease Relevance 0.73 Pain Relevance 0.40
In contrast, indomethacin, a cyclooxygenase inhibitor, or nordihydroguaiaretic acid, a lipoxygenase inhibitor, were ineffective.
Regulation (ineffective) of lipoxygenase
10) Confidence 0.18 Published 1996 Journal Acta Physiol. Scand. Section Abstract Doc Link 8735652 Disease Relevance 0 Pain Relevance 0.14
We conclude that (1) islet lipoxygenase is constitutively expressed and is not physiologically regulated by alpha 2-adrenergic agonism, Ca2+ or protein kinases; (2) lipoxygenase modulates insulin release; HETE production is not merely an epiphenomenon reflecting the activation (or inhibition) of exocytotic secretion; (3) islet lipoxygenase inhibitors reduce insulin secretion, at least in part, by blocking the direct effects of Ca2+ on exocytosis and/or its synergism with Ca2+-binding proteins such as protein kinase C; and (4) these same inhibitors do not directly poison protein kinase C or A, or the exocytotic apparatus.
Neg (not) Regulation (regulated) of lipoxygenase associated with kinase c and poisoning
11) Confidence 0.18 Published 1989 Journal Biochem. Pharmacol. Section Abstract Doc Link 2567595 Disease Relevance 0.08 Pain Relevance 0.30
In addition, since xenobiotic metabolism, reactive oxygen and nitrogen species, atherosclerosis and inflammation are interrelated and mutually affected, the effects of and on acute inflammation in vivo and lipoxygenase activity in vitro were also investigated.
Regulation (effects) of lipoxygenase associated with inflammation and increased venous pressure under development
12) Confidence 0.17 Published 2005 Journal Curr. Drug Metab. Section Abstract Doc Link 16248839 Disease Relevance 0.48 Pain Relevance 0.28
BW-B 70C down-regulated 5-LOX and inhibited iNOS expression by preventing NF-?
Regulation (regulated) of 5-LOX
13) Confidence 0.15 Published 2006 Journal J Neuroinflammation Section Abstract Doc Link PMC1526713 Disease Relevance 0.77 Pain Relevance 0.17
Effects of phospholipase A2 inhibitor, cyclooxygenase inhibitor and lipoxygenase inhibitor on glucagon secretion induced by the alpha 2-adrenergic agonist clonidine were studied in the isolated perfused rat pancreas.
Regulation (Effects) of lipoxygenase in pancreas associated with agonist and clonidine
14) Confidence 0.10 Published 1992 Journal Diabetes Res. Clin. Pract. Section Abstract Doc Link 1330464 Disease Relevance 0 Pain Relevance 0.39
Similarly to other lipoxygenase inhibitors and hydroxyl radical scavenger NSAIDs, melanin treatment did not affect IL-1 neither increased the splenic mitogenic responses, unlike the classical cyclooxygenase inhibitory NSAIDs.
Neg (not) Regulation (affect) of lipoxygenase associated with cinod
15) Confidence 0.07 Published 1998 Journal Arzneimittelforschung Section Abstract Doc Link 9706378 Disease Relevance 1.02 Pain Relevance 0.45
These observations indicate that 5-LOX protein is up regulated mainly in microglia/macrophage and neurons in the ipsilateral hemisphere after IR injury.


Regulation (regulated) of 5-LOX protein in neurons associated with injury
16) Confidence 0.07 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1526713 Disease Relevance 0.57 Pain Relevance 0.06
These observations indicate that 5-LOX protein is up regulated mainly in microglia/macrophage and neurons in the ipsilateral hemisphere after IR injury.


Regulation (regulated) of 5-LOX protein in macrophage associated with injury
17) Confidence 0.07 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1526713 Disease Relevance 0.57 Pain Relevance 0.06
Amentoflavone was also found to inhibit cyclooxygenase from guinea-pig epidermis without affecting lipoxygenase.
Neg (without) Regulation (affecting) of lipoxygenase in epidermis
18) Confidence 0.06 Published 1998 Journal Arch. Pharm. Res. Section Abstract Doc Link 9875467 Disease Relevance 0.60 Pain Relevance 0.32
Effects of some non-steroidal anti-inflammatory drugs and other agents on cyclooxygenase and lipoxygenase activities in some enzyme preparations.
Regulation (Effects) of lipoxygenase associated with inflammation and cinod
19) Confidence 0.06 Published 1985 Journal Jpn. J. Pharmacol. Section Title Doc Link 3928952 Disease Relevance 0.20 Pain Relevance 0.41
The inhibiting influences of some non-steroidal anti-inflammatory drugs (NSAIDs) and other agents on cyclooxygenase (CO) and lipoxygenase (LO) activities in some enzyme preparations were investigated.
Regulation (influences) of lipoxygenase associated with inflammation and cinod
20) Confidence 0.05 Published 1985 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 3928952 Disease Relevance 0.17 Pain Relevance 0.38

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