INT6596

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Latest revision as of 12:32, 23 September 2012

Context Info
Confidence 0.61
First Reported 1989
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 33
Total Number 35
Disease Relevance 27.01
Pain Relevance 7.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DRB1) Golgi apparatus (HLA-DRB1) endoplasmic reticulum (HLA-DRB1)
plasma membrane (HLA-DRB1)
Anatomy Link Frequency
T-lymphocytes 3
macrophages 2
platelet 2
cytotoxic T lymphocytes 1
blood 1
HLA-DRB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 4 100.00 Very High Very High Very High
Migraine 77 99.78 Very High Very High Very High
Arthritis 21 99.40 Very High Very High Very High
Multiple sclerosis 162 99.12 Very High Very High Very High
tetrodotoxin 1 98.40 Very High Very High Very High
Inflammation 139 97.84 Very High Very High Very High
chemokine 19 97.40 Very High Very High Very High
cytokine 46 97.28 Very High Very High Very High
Angina 27 97.00 Very High Very High Very High
spinal inflammation 26 96.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pulmonary Disease 267 99.84 Very High Very High Very High
Headache 73 99.78 Very High Very High Very High
Disease 284 99.72 Very High Very High Very High
Mucocutaneous Lymph Node Syndrome 166 99.68 Very High Very High Very High
Nicotine Addiction 274 99.48 Very High Very High Very High
Arthritis 23 99.40 Very High Very High Very High
Demyelinating Disease 168 99.12 Very High Very High Very High
Syndrome 22 99.12 Very High Very High Very High
Idiopathic Thrombocytopenic Purpura 42 99.08 Very High Very High Very High
Hypotension 2 98.80 Very High Very High Very High

[edit] Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, when the patients were compared by subgroups, with and without CC, the frequency of HLA-DRB1*11 was significantly increased in the Kawasaki disease patients with CC (p < 0.04; RR = 4.7), and HLA-DRB1*04 was increased in the Kawasaki disease patients without CC (p < 0.05; RR =1.9) compared with the healthy control group.
Positive_regulation (increased) of HLA-DRB1 associated with mucocutaneous lymph node syndrome
1) Confidence 0.61 Published 2007 Journal Pediatr Cardiol Section Body Doc Link PMC2267487 Disease Relevance 1.40 Pain Relevance 0
The frequency of the HLA DRB1*12 allele was found to be decreased in patients with migraine while the DRB1*16 allele, coding for HLA DR2 antigen, was significantly increased in comparison with controls.
Positive_regulation (increased) of DRB1 associated with migraine
2) Confidence 0.59 Published 2007 Journal J Headache Pain Section Body Doc Link PMC2779399 Disease Relevance 1.33 Pain Relevance 0.59
To conclude, patients with VKH had a higher incidence of HLA-DRB1 *0405, indicating that the HLA-DRB1 *0405 allele might play a role in the pathogenesis of VKH disease.



Positive_regulation (incidence) of HLA-DRB1 associated with disease
3) Confidence 0.50 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2743806 Disease Relevance 0.97 Pain Relevance 0
The HLA-DRB1 promoter was resequenced in 322 HLA-DRB1*15 homozygous individuals, both MS affected and unaffected.
Positive_regulation (resequenced) of HLA-DRB1*15 associated with multiple sclerosis
4) Confidence 0.49 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2627899 Disease Relevance 0.40 Pain Relevance 0.20
Further, extension of the analysis from HLA-A to HLA-DRB1 increases the size of allele-defined CEHs up to 2.6 Mb.
Positive_regulation (increases) of HLA-DRB1
5) Confidence 0.48 Published 2007 Journal BMC Genet Section Body Doc Link PMC1853106 Disease Relevance 0 Pain Relevance 0
Regarding DR locus, the frequency of HLA-DRB1*15 and DRB1*04 has been increased in CDMS patients, whilst the frequency of HLA-DRB1*07 and *11 was much higher in ON patients.
Positive_regulation (increased) of DRB1 associated with neuritis
6) Confidence 0.47 Published 2005 Journal Eur. J. Neurol. Section Abstract Doc Link 15613143 Disease Relevance 1.17 Pain Relevance 0.98
Kim and associates found that HLA-DRB1 *0405 was greatly increased in patients with VKH syndrome among Koreans and might have an important role in the development of the clinical course of VKH [11].
Positive_regulation (increased) of HLA-DRB1 associated with syndrome and disease
7) Confidence 0.47 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2743806 Disease Relevance 2.01 Pain Relevance 0
Flow cytometric analysis showed a specific increase in the cell surface expression of HLA-DRB1 upon addition of vitamin D only in HLA-DRB1*15 bearing lymphoblastoid cells.
Positive_regulation (increase) of DRB1
8) Confidence 0.43 Published 2009 Journal PLoS Genetics Section Abstract Doc Link PMC2627899 Disease Relevance 0.73 Pain Relevance 0.16
The HLA-DRB1 promoter was resequenced in 322 HLA-DRB1*15 homozygous individuals, both MS affected and unaffected.
Positive_regulation (resequenced) of DRB1 associated with multiple sclerosis
9) Confidence 0.43 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2627899 Disease Relevance 0.40 Pain Relevance 0.20
Regarding DR locus, the frequency of HLA-DRB1*15 and DRB1*04 has been increased in CDMS patients, whilst the frequency of HLA-DRB1*07 and *11 was much higher in ON patients.
Positive_regulation (increased) of DRB1 associated with neuritis
10) Confidence 0.41 Published 2005 Journal Eur. J. Neurol. Section Abstract Doc Link 15613143 Disease Relevance 1.18 Pain Relevance 0.99
Among the HLA-DRB1 alleles, there was no increase in the frequency of alleles in the Kawasaki disease patients compared with the healthy control group.
Neg (no) Positive_regulation (increase) of HLA-DRB1 associated with mucocutaneous lymph node syndrome
11) Confidence 0.41 Published 2007 Journal Pediatr Cardiol Section Body Doc Link PMC2267487 Disease Relevance 0.97 Pain Relevance 0
The myeloid dendritic cells in CSF expressed higher levels of HLA-DR, CD86, CD80 and CD40 than those in blood, whereas expression of these molecules by plasmacytoid dendritic cells was equal in blood and CSF.
Positive_regulation (levels) of HLA-DR in blood
12) Confidence 0.34 Published 2001 Journal Brain Section Abstract Doc Link 11222448 Disease Relevance 1.00 Pain Relevance 0.43
Among HLA-DRB1 alleles, a significant increase in DRB1*11 was found in comparison with controls (P = 0.01, OR = 2.2, 1.2 < CI < 4.5).
Positive_regulation (increase) of DRB1
13) Confidence 0.33 Published 2010 Journal Rheumatol. Int. Section Abstract Doc Link 19655145 Disease Relevance 0.66 Pain Relevance 0.60
The increase of HLA-DR12 and HLA-DR1 in AU may be caused by linkage disequilibrium with B*2704 and B*2705, respectively.


Positive_regulation (increase) of HLA-DR12
14) Confidence 0.32 Published 1999 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 10393058 Disease Relevance 0.05 Pain Relevance 0
The increase of HLA-DR12 and HLA-DR1 in AU may be caused by linkage disequilibrium with B*2704 and B*2705, respectively.


Positive_regulation (increase) of HLA-DR1
15) Confidence 0.32 Published 1999 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 10393058 Disease Relevance 0.05 Pain Relevance 0
Among HLA-DRB1 alleles, a significant increase in DRB1*11 was found in comparison with controls (P = 0.01, OR = 2.2, 1.2 < CI < 4.5).
Positive_regulation (increase) of DRB1
16) Confidence 0.29 Published 2010 Journal Rheumatol. Int. Section Abstract Doc Link 19655145 Disease Relevance 0.67 Pain Relevance 0.60
In HLA-B27-associated AU, DRB1*0101 and DQB1*0501 were increased compared with HLA-B27-positive control subjects.
Positive_regulation (increased) of DRB1
17) Confidence 0.21 Published 1999 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 10393058 Disease Relevance 0.07 Pain Relevance 0
Cell surface marker analysis of blast cells disclosed that they were positive for anti-HLA-DR, CD19, CD24, CD33 and CD38, but were negative for CD10 and CD20.
Positive_regulation (positive) of anti-HLA-DR in blast cells
18) Confidence 0.13 Published 1989 Journal Rinsho Ketsueki Section Abstract Doc Link 2554012 Disease Relevance 0.58 Pain Relevance 0.12
The bottoms of these stromal bundles are adjacent (see border lines, panel B) and their migration appears to be influenced by HLA-DR+ (activated [67]) tissue macrophages (purple color, black and white arrows, panel C).
Positive_regulation (activated) of HLA-DR in macrophages
19) Confidence 0.11 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC420494 Disease Relevance 0 Pain Relevance 0
In addition to its effects on airway neutrophilia, we have recently reported that O3 challenge (0.4 ppm, 2 hr) causes an increase in expression of cell-surface phenotypes CD11b, mCD14, CD16, CD86, and HLA-DR on sputum monocytes recovered from normal volunteers (Alexis et al. 2004a).
Positive_regulation (phenotypes) of HLA-DR in CD86
20) Confidence 0.11 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 0.17 Pain Relevance 0

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