INT65985

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Context Info
Confidence 0.23
First Reported 1996
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.62
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (PTGS2) aging (IL1B) endoplasmic reticulum (PTGS2)
enzyme binding (PTGS2) protein complex (PTGS2) cytoplasm (PTGS2)
Anatomy Link Frequency
astrocytes 2
IL1B (Homo sapiens)
PTGS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 11 100.00 Very High Very High Very High
COX2 4 100.00 Very High Very High Very High
Inflammatory mediators 1 99.56 Very High Very High Very High
cytokine 8 97.68 Very High Very High Very High
chemokine 1 97.12 Very High Very High Very High
cINOD 8 89.04 High High
Pain 2 86.92 High High
Hippocampus 1 55.76 Quite High
aspirin 31 50.00 Quite Low
COX-2 inhibitor 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 14 100.00 Very High Very High Very High
Neuroblastoma 3 99.60 Very High Very High Very High
Cancer 17 98.20 Very High Very High Very High
Disease 13 92.08 High High
Metastasis 3 90.76 High High
Fever 2 88.96 High High
Gliosis 1 88.24 High High
Malignant Neoplastic Disease 2 87.20 High High
Pain 2 86.92 High High
Breast Cancer 24 77.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interleukin-1beta induces cyclooxygenase-2 and prostaglandin E(2) synthesis in human neuroblastoma cells: involvement of p38 mitogen-activated protein kinase and nuclear factor-kappaB.
Interleukin-1beta Positive_regulation (induces) of Gene_expression (synthesis) of cyclooxygenase-2 associated with neuroblastoma and cox2
1) Confidence 0.23 Published 2000 Journal J. Neurochem. Section Title Doc Link 11032891 Disease Relevance 0.51 Pain Relevance 0.17
We have previously shown that PGHS-2 message is induced by Interleukin-1 beta and other inflammatory mediators in primary cultures of rodent astrocytes.
Interleukin-1 beta Positive_regulation (induced) of Gene_expression (message) of PGHS-2 in astrocytes associated with inflammatory mediators
2) Confidence 0.23 Published 1996 Journal Neurobiol. Aging Section Abstract Doc Link 8892355 Disease Relevance 0.99 Pain Relevance 0.21
In addition, IL-1 induce the expression of pro-inflammatory enzymes mainly Cyclooxygenase 2 (COX-2), inducible nitric oxide (iNOS), as well as other cytokines and chemokines.
IL-1 Positive_regulation (induce) of Gene_expression (expression) of Cyclooxygenase 2 associated with chemokine, inflammation, cox2 and cytokine
3) Confidence 0.14 Published 2006 Journal Int Semin Surg Oncol Section Body Doc Link PMC1569375 Disease Relevance 1.11 Pain Relevance 0.33

General Comments

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