INT66191

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Context Info
Confidence 0.66
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 42
Total Number 44
Disease Relevance 22.25
Pain Relevance 3.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (DBP)
Anatomy Link Frequency
blood 5
liver 1
cerebrospinal fluid 1
parenchymal cells 1
epithelium 1
DBP (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 12 98.72 Very High Very High Very High
Multiple sclerosis 266 96.56 Very High Very High Very High
Inflammation 125 94.20 High High
ischemia 7 93.32 High High
Pain 12 91.72 High High
Inflammatory response 7 90.76 High High
Restless leg syndrome 2 87.64 High High
Inflammatory marker 16 86.40 High High
Central nervous system 36 86.28 High High
cva 29 81.44 Quite High
Disease Link Frequency Relevance Heat
Hypertension 603 100.00 Very High Very High Very High
Diabetes Mellitus 236 100.00 Very High Very High Very High
Neuromyelitis Optica 405 99.88 Very High Very High Very High
Stress 258 99.36 Very High Very High Very High
Peripheral Arterial Disease 67 98.72 Very High Very High Very High
Hypotension 55 98.72 Very High Very High Very High
Disorder Of Lipid Metabolism 77 98.00 Very High Very High Very High
Demyelinating Disease 285 96.56 Very High Very High Very High
Diabetic Nephropathy 34 95.88 Very High Very High Very High
Coronary Artery Disease 72 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Amlodipine significantly reduced ambulatory BP values compared with baseline values: mean decreases in 24-hour, daytime, and nighttime SBP/DBP were: ?
Gene_expression (were) of DBP
1) Confidence 0.66 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835558 Disease Relevance 0 Pain Relevance 0
6.4 ± 2.7 mmHg for nighttime) than with the losartan/amlodipine combination (SBP/DBP: ?
Gene_expression (with) of DBP
2) Confidence 0.66 Published 2010 Journal Vascular Health and Risk Management Section Abstract Doc Link PMC2835558 Disease Relevance 0.14 Pain Relevance 0
Averaged 24-hour, daytime, and nighttime ambulatory SBP and DBP values are shown in Table 2.
Gene_expression (values) of DBP
3) Confidence 0.66 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835558 Disease Relevance 0.10 Pain Relevance 0
6.4 ± 2.7 mmHg for nighttime) than with the losartan/amlodipine combination (SBP/DBP: ?
Gene_expression (/) of DBP
4) Confidence 0.66 Published 2010 Journal Vascular Health and Risk Management Section Abstract Doc Link PMC2835558 Disease Relevance 0.14 Pain Relevance 0
Amlodipine significantly reduced ambulatory BP values compared with baseline values: mean decreases in 24-hour, daytime, and nighttime SBP/DBP were: ?
Gene_expression (/) of DBP
5) Confidence 0.66 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835558 Disease Relevance 0 Pain Relevance 0
However, with the valsartan/amlodipine combination, the further mean reduction in BP (SBP/DBP: ?
Gene_expression (/) of DBP
6) Confidence 0.66 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835558 Disease Relevance 0 Pain Relevance 0
6.4±2.7 mmHg for nighttime) was greater than that seen with the losartan/amlodipine combination (SBP/DBP: ?
Gene_expression (/) of DBP
7) Confidence 0.66 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835558 Disease Relevance 0 Pain Relevance 0
We observed significant positive correlations between urinary levels of DBP and renal tubular dysfunction markers in both groups.
Gene_expression (levels) of DBP
8) Confidence 0.60 Published 2007 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 17347552 Disease Relevance 0.44 Pain Relevance 0.06
SBP, DBP, MAP and HR are presented in table 1.
Gene_expression (presented) of DBP
9) Confidence 0.59 Published 2005 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1185546 Disease Relevance 1.38 Pain Relevance 0
SBP, DBP and MAP were significantly higher in the novelty stress and stress periods (day 1) compared to control 1 and 2 (day 2), whereas HR tended to be higher in the novelty stress and stress periods compared to control 1 and 2 (P = 0.055).
Gene_expression (higher) of DBP associated with stress
10) Confidence 0.59 Published 2005 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1185546 Disease Relevance 1.45 Pain Relevance 0
Allosteric modulation of the TCA binding site may occur in the setting of phenytoin use.
Gene_expression (modulation) of binding site
11) Confidence 0.59 Published 2010 Journal Clin Toxicol (Phila) Section Body Doc Link 20507243 Disease Relevance 0 Pain Relevance 0
Patients with sitting DBP ?
Gene_expression (sitting) of DBP
12) Confidence 0.58 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835558 Disease Relevance 0.89 Pain Relevance 0.10
When the duration of hypotensive action was evaluated over 24 hours, the T/P ratios for SBP and DBP obtained with both the combinations given once daily fulfilled United States Food and Drug Administration guidelines for efficacy (T/P ratio > 50%); however, the ratio was greater with valsartan/amlodipine than with losartan/amlodipine.
Gene_expression (obtained) of DBP associated with hypotension
13) Confidence 0.58 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835558 Disease Relevance 0.40 Pain Relevance 0
However, due to some small CSF specimens, we were able to perform both gelsolin and DBP analysis in only 24 samples.


Gene_expression (analysis) of DBP
14) Confidence 0.58 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.69 Pain Relevance 0.25
Similar to gelsolin depletion, low DBP levels (both the total level and the actin-free level, which is an index of residual actin-scavenging capacity), was proposed to serve as a prognostic marker in situations of organ damage such as acute liver failure, and multiple trauma [18].
Gene_expression (depletion) of DBP in liver associated with acute liver failure and multiple trauma
15) Confidence 0.58 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 1.05 Pain Relevance 0.06
Gelsolin and DBP concentration in cerebrospinal fluid
Gene_expression (concentration) of DBP in cerebrospinal fluid
16) Confidence 0.58 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.81 Pain Relevance 0.36
AK: participated in study design, collection of CSF samples, helped to draft the manuscript; NJC: carried out GSN studies; QW: statistical evaluation, helped to draft the manuscript; BM: carried out DBP studies helped to draft the manuscript; WD: participated in study design, helped to draft the manuscript; MS: participated in study design, helped to draft the manuscript; PAJ: participated in study design, helped to draft the manuscript; RB: carried out F-actin studies, participated in study design, helped to draft the manuscript.
Gene_expression (studies) of DBP associated with multiple sclerosis
17) Confidence 0.50 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.36 Pain Relevance 0.17
MAIN RESULTS: All postintubation values of SBP, DBP, MAP, and HR were significantly lower in the lidocaine group than the control group (P < 0.01).
Gene_expression (values) of DBP
18) Confidence 0.49 Published 2009 Journal J Clin Anesth Section Body Doc Link 19329013 Disease Relevance 0 Pain Relevance 0
In HP basal testosterone levels were lower than those in NS (1.25 +/- 0.3 vs 7.34 +/- 1.5 ng/ml, p < 0.05) and were restored to normal by hormonal replacement (6.91 +/- 1.3 ng/mL) in HP, both SBP and DBP as well as PR were normal in basal conditions and were not modified by testosterone replacement.
Gene_expression (normal) of DBP
19) Confidence 0.41 Published 1996 Journal J. Endocrinol. Invest. Section Abstract Doc Link 8905472 Disease Relevance 0.14 Pain Relevance 0.40
The mean sBP and dBP increased significantly over time (p = 0.010 and 0.001, respectively, see Figure 1); this continuous rise of the blood pressure over the monitoring period was not different between groups (p > 0.28) and there was no significant group by epoch interaction (p > 0.55).
Gene_expression (increased) of dBP in blood
20) Confidence 0.40 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844382 Disease Relevance 0 Pain Relevance 0

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