INT66199

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Context Info
Confidence 0.46
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 6.88
Pain Relevance 2.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Gfap) extracellular matrix organization (Gfap) cytoplasm (Gfap)
Anatomy Link Frequency
astrocytes 2
neuronal 1
spinal cord 1
stellate cells 1
amacrine cells 1
Gfap (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 4 100.00 Very High Very High Very High
Kappa opioid receptor 80 99.84 Very High Very High Very High
medulla 77 99.24 Very High Very High Very High
Inflammation 140 99.12 Very High Very High Very High
Spinal cord 141 98.68 Very High Very High Very High
Hippocampus 62 98.16 Very High Very High Very High
anesthesia 8 96.64 Very High Very High Very High
Central nervous system 73 89.40 High High
cytokine 82 88.88 High High
Glutamate 65 88.24 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 157 99.12 Very High Very High Very High
Targeted Disruption 200 98.76 Very High Very High Very High
Brain Injury 30 98.76 Very High Very High Very High
Creutzfeldt Jakob Disease 1 98.12 Very High Very High Very High
Death 65 97.40 Very High Very High Very High
Injury 178 96.92 Very High Very High Very High
Stab Wounds 30 96.64 Very High Very High Very High
Ganglion Cysts 45 95.64 Very High Very High Very High
Parkinson's Disease 19 94.48 High High
Sprains And Strains 10 94.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Accordingly, quantitative analysis of GFAP blots revealed a significant reduction of GFAP protein levels in the lithium-treated Tg mice compared to Tg controls (Fig. 6 K,L).


Negative_regulation (reduction) of GFAP protein associated with targeted disruption
1) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004858 Disease Relevance 0.67 Pain Relevance 0.12
Although we observed decreased GFAP expression at this time point, our data indicate that there is reduced GFAP per cell rather than fewer astrocytes.
Negative_regulation (reduced) of GFAP in astrocytes
2) Confidence 0.42 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.57 Pain Relevance 0.27
Here we examined, using in situ hybridization histochemistry, the expression of neuropeptide Y (NPY), an inducible and abundant neuropeptide in mammalian brain with known neuroregulatory functions, and glial fibrillary acidic protein (GFAP), a marker for astroglial activation, in the hippocampus at different time points following intracerebral prion inoculation in male CD-1 mice.
Spec (examined) Negative_regulation (using) of GFAP in brain associated with neuropeptide and hippocampus
3) Confidence 0.41 Published 1996 Journal Neuroreport Section Abstract Doc Link 8905686 Disease Relevance 0.33 Pain Relevance 0.35
Transduced PEDF potently and efficaciously reduces RGC loss and vision decline in DBA/2J mice, possibly via the reduction of TNF and IL-18, and downregulation of GFAP.
Negative_regulation (downregulation) of GFAP
4) Confidence 0.40 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2647972 Disease Relevance 0.39 Pain Relevance 0.09
In this region, the intensity of GFAP-IR was also decreased in KOR-/- and norBNI treated mice compared to WT mice.
Negative_regulation (decreased) of GFAP-IR associated with kappa opioid receptor
5) Confidence 0.35 Published 2010 Journal Mol Pain Section Body Doc Link PMC2826348 Disease Relevance 0.48 Pain Relevance 0.52
FGF-2 Labeling intensity in GFAP-positive and GFAP-negative cells
Negative_regulation (intensity) of GFAP
6) Confidence 0.33 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0 Pain Relevance 0.14
At P40, there was a significant reduction of GAD65 density in GFAP-Cre::CHL1flx/flx mice compared to CHL1flx/flx controls (Figure 8D, 8F, and 8H; 27 ± 7%; p ?
Negative_regulation (reduction) of GFAP
7) Confidence 0.33 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0.34 Pain Relevance 0
At P14, P20, and P40 in GFAP-Cre::CHL1flx/flx mice, CHL1 expression was undectable along BG fibers but was clearly present in stellate cells (Figure 8A–8C).
Negative_regulation (undectable) of GFAP in stellate cells
8) Confidence 0.33 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0.34 Pain Relevance 0
However, compared to the WT counterparts GFAP levels were attenuated at the early time point (3 days post lesion) in the receptor-null mice, but by 5 days of recovery GFAP achieved comparable levels to injured WT mice.
Negative_regulation (attenuated) of GFAP
9) Confidence 0.31 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.54 Pain Relevance 0.03
In addition, GFAP was significantly reduced in the BV-treated brainstem and spinal cord when compared with age-matched familial mutant SOD1 mice (Figure 7B).
Negative_regulation (reduced) of GFAP in spinal cord associated with medulla and spinal cord
10) Confidence 0.31 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2974667 Disease Relevance 0.47 Pain Relevance 0.33
Supporting this idea, BV treatment significantly increased the expression of a neuronal cell marker and reduced GFAP levels when compared with age-matched hSOD1G93A transgenic mice (Figure 7A-B).
Negative_regulation (reduced) of GFAP in neuronal associated with targeted disruption
11) Confidence 0.31 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2974667 Disease Relevance 1.00 Pain Relevance 0.35
For costaining in paraffin tissue of GFAP and A?
Negative_regulation (tissue) of GFAP
12) Confidence 0.30 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1274341 Disease Relevance 0.07 Pain Relevance 0
In adult rats, the number of astrocytes was shown to remain unchanged after traumatic brain injury in one study [31], while in another similar study, there was loss of GFAP reactivity in the ipsilateral CA3 region of the hippocampus 30 minutes after injury with progressive astrocyte loss over the next 24 hours [32].
Negative_regulation (loss) of GFAP in astrocytes associated with injury, hippocampus and brain injury
13) Confidence 0.28 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC555560 Disease Relevance 0.93 Pain Relevance 0.05
A normal distribution of glial fibrillary acid protein (GFAP; labels Muller cells), calbindin- (CALB; labels horizontal cells) and choline acetyltransferase (ChAT; labels cholinergic amacrine cells) immunoreactivity was observed in both control and UF008/SAP injected eyes.
Negative_regulation (distribution) of glial fibrillary acid protein in amacrine cells
14) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2519834 Disease Relevance 0.30 Pain Relevance 0
In addition, GFAP was significantly reduced in the BV-treated brainstem and spinal cord when compared with age-matched familial mutant SOD1 mice (Figure 7B).
Negative_regulation (reduced) of GFAP in brainstem associated with medulla and spinal cord
15) Confidence 0.10 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2974667 Disease Relevance 0.47 Pain Relevance 0.33

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