INT66531

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Context Info
Confidence 0.78
First Reported 1996
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 88
Total Number 90
Disease Relevance 22.90
Pain Relevance 65.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pnoc)
Anatomy Link Frequency
neurons 10
spinal 9
brain 7
central nervous system 3
spinal cord 3
Pnoc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
orphanin 643 100.00 Very High Very High Very High
Pain 174 100.00 Very High Very High Very High
Opioid 80 100.00 Very High Very High Very High
opioid receptor 71 100.00 Very High Very High Very High
narcan 47 100.00 Very High Very High Very High
Neuropeptide 36 100.00 Very High Very High Very High
Dynorphin 35 100.00 Very High Very High Very High
agonist 33 100.00 Very High Very High Very High
Enkephalin 29 100.00 Very High Very High Very High
nociceptor 17 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 51 100.00 Very High Very High Very High
Pain 163 99.96 Very High Very High Very High
Hyperalgesia 17 99.96 Very High Very High Very High
Neuropathic Pain 27 99.84 Very High Very High Very High
Stroke 8 99.84 Very High Very High Very High
Hepatocellular Cancer 2 99.84 Very High Very High Very High
INFLAMMATION 29 99.74 Very High Very High Very High
Inflammatory Pain 11 99.46 Very High Very High Very High
Ganglion Cysts 2 99.40 Very High Very High Very High
Depression 3 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As changes in the receptor density and expression of the message for nociceptin have been reported after inflammation we have compared these actions to previously reported effects in normal animals.
Gene_expression (expression) of nociceptin associated with inflammation and orphanin
1) Confidence 0.78 Published 2000 Journal Pain Section Abstract Doc Link 10781916 Disease Relevance 0.40 Pain Relevance 0.88
The majority of functional studies using behavioral and electrophysiological studies have shown that nociceptin applied at spinal level produces antinociception through pre- and post-synaptic mechanisms.
Gene_expression (produces) of nociceptin in spinal associated with antinociception and orphanin
2) Confidence 0.78 Published 2000 Journal Peptides Section Abstract Doc Link 10998537 Disease Relevance 0.34 Pain Relevance 1.01
Both PNOC and OPRL1 were present in the uterus.
Gene_expression (present) of PNOC in uterus
3) Confidence 0.78 Published 2010 Journal Biol. Reprod. Section Abstract Doc Link 20237332 Disease Relevance 0.24 Pain Relevance 0.31
The immunohistochemical data show that nociceptin is expressed in limbic cortical regions, including the piriform cortex and the hippocampus.
Gene_expression (expressed) of nociceptin in piriform cortex associated with orphanin and hippocampus
4) Confidence 0.77 Published 2001 Journal Neuroscience Section Abstract Doc Link 11672600 Disease Relevance 0.13 Pain Relevance 0.70
The results suggest that peripheral inflammation induces the production of nociceptin in a sub-population of VR1-positive primary sensory neurons and support the idea that nociceptin produced there is involved in the regulation of nociceptive processing.
Gene_expression (production) of nociceptin in primary sensory neurons associated with nociception, vanilloid receptor subtype 1, inflammation and orphanin
5) Confidence 0.76 Published 2001 Journal Neurosci. Res. Section Abstract Doc Link 11448514 Disease Relevance 0.49 Pain Relevance 0.75
Expression of the neuropeptide orphanin FQ/nociceptin (OFQ/N) and its receptor, the opioid receptor-like receptor (ORL1), have been found to have a wide distribution in the central nervous system, and in brain areas involved in sensory perception in particular.
Gene_expression (Expression) of orphanin FQ in central nervous system associated with orphanin, neuropeptide, central nervous system and opioid receptor
6) Confidence 0.75 Published 2002 Journal Brain Res. Section Abstract Doc Link 12126889 Disease Relevance 0.07 Pain Relevance 0.47
Changes in expression of nociceptin/orphanin FQ and its receptor in spinal dorsal horn during electroacupuncture treatment for peripheral inflammatory pain in rats.
Gene_expression (expression) of orphanin FQ in spinal associated with inflammation, ipn, spinal dorsal horn, orphanin and electroacupuncture
7) Confidence 0.75 Published 2007 Journal Peptides Section Title Doc Link 17493706 Disease Relevance 0.46 Pain Relevance 1.68
Expression of orphanin FQ/nociceptin and its receptor in rat peripheral ganglia and spinal cord.
Gene_expression (Expression) of orphanin FQ in ganglia associated with orphanin and spinal cord
8) Confidence 0.75 Published 2002 Journal Brain Res. Section Title Doc Link 12126889 Disease Relevance 0.08 Pain Relevance 0.65
Nerve fibers immunoreactive to all enkephalins (Met-enkephalin, Leu-enkephalin, Met-enkephalin-Arg-Gly-Lys, Met-enkephalin-Arg-Phe) were consistently found in the loose connective tissue and the paratenon, whereas dynorphin B and nociceptin/orphanin FQ could not be detected.
Neg (not) Gene_expression (detected) of nociceptin in Nerve associated with dynorphin, orphanin and enkephalin
9) Confidence 0.75 Published 2001 Journal J. Histochem. Cytochem. Section Abstract Doc Link 11668192 Disease Relevance 0.10 Pain Relevance 1.59
This study investigates the influence of neuropathic pain on the expression of nociceptin using immunohistochemistry.
Gene_expression (expression) of nociceptin associated with orphanin and neuropathic pain
10) Confidence 0.72 Published 2004 Journal Anaesthesist Section Abstract Doc Link 15127152 Disease Relevance 0.68 Pain Relevance 1.31
Chronic inflammatory pain causes an increase in the expression of nociceptin and the ORL1 receptor in the dorsal horn of rat spinal cord, thus indicating an involvement of the endogenous nociceptin/ORL1 system in mechanisms of pathological pain.
Gene_expression (expression) of nociceptin in spinal cord associated with pain, orphanin, ipn, dorsal horn and spinal cord
11) Confidence 0.72 Published 2004 Journal Anaesthesist Section Abstract Doc Link 15127152 Disease Relevance 0.54 Pain Relevance 1.09
Reverse transcriptase-polymerase chain reaction analysis further revealed that the orphanin FQ receptor, ORL-1 is expressed in hypothalamic fragments, but not in GT1-7 neurons.
Neg (not) Gene_expression (expressed) of orphanin FQ in neurons associated with orphanin
12) Confidence 0.72 Published 2002 Journal Neuroreport Section Abstract Doc Link 12151779 Disease Relevance 0 Pain Relevance 0.40
Under constant-flow conditions, injections of endomorphins 1 and 2, PL017 ([N-MePhe3,D-Pro4]-morphiceptin), nociceptin and Tyr-D-Ala-Gly-MePhe-Gly(ol)-enkephalin (DAMGO) produced dose-dependent decreases in hindquarters perfusion pressure.
Gene_expression (produced) of nociceptin associated with orphanin and enkephalin
13) Confidence 0.71 Published 2002 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 11906489 Disease Relevance 0 Pain Relevance 0.47
Site-specific estrogen and progestin regulation of orphanin FQ/nociceptin and nociceptin opioid receptor mRNA expression in the female rat limbic hypothalamic system.
Gene_expression (expression) of nociceptin associated with orphanin and opioid receptor
14) Confidence 0.70 Published 2006 Journal J. Comp. Neurol. Section Title Doc Link 16538678 Disease Relevance 0.09 Pain Relevance 0.43
Nociceptin receptors are densely expressed in the suprachiasmatic nucleus, the principal pacemaker of circadian rhythms, and nociceptin inhibits light-induced phase advances (Allen et al, 1999); however, nociceptin's role in nonphotic entrainment has not been described.
Gene_expression (expressed) of Nociceptin in suprachiasmatic nucleus associated with orphanin
15) Confidence 0.68 Published 2005 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 16313096 Disease Relevance 0.10 Pain Relevance 0.63
Diuretic and antinatriuretic responses produced by the endogenous opioid-like peptide, nociceptin (orphanin FQ).
Gene_expression (produced) of nociceptin associated with orphanin and endogenous opioid
16) Confidence 0.68 Published 1997 Journal Life Sci. Section Title Doc Link 8995537 Disease Relevance 0.19 Pain Relevance 0.93
Here we report that nociceptin is physiologically active in vivo and produces marked changes in the renal excretion of water and sodium.
Gene_expression (produces) of nociceptin associated with orphanin
17) Confidence 0.68 Published 1997 Journal Life Sci. Section Abstract Doc Link 8995537 Disease Relevance 0.14 Pain Relevance 0.81
Orphanin FQ produces gender-specific modulation of trigeminal nociception: behavioral and electrophysiological observations.
Gene_expression (produces) of Orphanin FQ associated with nociception and orphanin
18) Confidence 0.67 Published 2001 Journal Neuroscience Section Title Doc Link 11672614 Disease Relevance 0.48 Pain Relevance 0.83
It has been reported that intracerebroventricularly injected nociceptin produced hyperalgesia in mice and that intrathecal injection of nociceptin inhibits the spinal sensitization.
Gene_expression (produced) of nociceptin in spinal associated with hyperalgesia, spinal sensitization, orphanin and intrathecal
19) Confidence 0.67 Published 1997 Journal Neuroscience Section Abstract Doc Link 9300417 Disease Relevance 0.18 Pain Relevance 0.87
Here we report that intrathecal orphanin FQ produces dose-dependent depression of a spinal nociceptive flexor reflex in the rat.
Gene_expression (produces) of orphanin FQ in spinal associated with nociception, depression, orphanin and intrathecal
20) Confidence 0.67 Published 1996 Journal Neuroreport Section Abstract Doc Link 8930965 Disease Relevance 0.42 Pain Relevance 1.03

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