INT66755

From wiki-pain
Revision as of 22:12, 23 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.72
First Reported 1996
Last Reported 2010
Negated 3
Speculated 2
Reported most in Abstract
Documents 45
Total Number 48
Disease Relevance 37.10
Pain Relevance 19.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnf) extracellular space (Tnf) extracellular region (Tnf)
plasma membrane (Tnf) intracellular (Tnf) extracellular matrix organization (Tnf)
Anatomy Link Frequency
brain 2
Lungs 2
lymph node 2
peritoneal macrophages 2
neurons 2
Tnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 162 100.00 Very High Very High Very High
cytokine 143 100.00 Very High Very High Very High
chemokine 2 100.00 Very High Very High Very High
Pain 50 99.90 Very High Very High Very High
dorsal root ganglion 7 99.84 Very High Very High Very High
Neuritis 21 99.32 Very High Very High Very High
gABA 8 99.32 Very High Very High Very High
ischemia 114 99.24 Very High Very High Very High
Thalamus 3 99.12 Very High Very High Very High
Sciatic nerve 65 99.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 167 100.00 Very High Very High Very High
Necrosis 49 100.00 Very High Very High Very High
Cancer 42 100.00 Very High Very High Very High
Pain 53 99.90 Very High Very High Very High
Sepsis 32 99.72 Very High Very High Very High
Brain Injury 4 99.56 Very High Very High Very High
Immunization 5 99.38 Very High Very High Very High
Ganglion Cysts 7 99.36 Very High Very High Very High
Experimental Autoimmune Neuritis 20 99.32 Very High Very High Very High
Adhesions 6 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibitory effect of amygdalin on lipopolysaccharide-inducible TNF-alpha and IL-1beta mRNA expression and carrageenan-induced rat arthritis.
Transcription (expression) of TNF-alpha associated with arthritis
1) Confidence 0.72 Published 2008 Journal J. Microbiol. Biotechnol. Section Title Doc Link 18955812 Disease Relevance 0.77 Pain Relevance 0.49
CONCLUSIONS: (i) Aspirin directly stimulates TNFalpha gene transcription; (ii) TACE inhibitors protect against aspirin-induced gastric mucosal injury; and (iii) TNFalpha exerts a direct cytotoxic effect on gastric epithelial cells.


Transcription (transcription) of TNFalpha in epithelial cells
2) Confidence 0.71 Published 1998 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9845404 Disease Relevance 0 Pain Relevance 0
The levels of the tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta) and interleukin 10 (IL-10) mRNA in the tissue were estimated by reverse transcription-polymerase chain reaction (RT-PCR).
Transcription (levels) of tumor necrosis factor-alpha associated with necrosis and cancer
3) Confidence 0.71 Published 2009 Journal Phytother Res Section Abstract Doc Link 19067390 Disease Relevance 1.08 Pain Relevance 0.61
The levels of the tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta) and interleukin 10 (IL-10) mRNA in the tissue were estimated by reverse transcription-polymerase chain reaction (RT-PCR).
Transcription (levels) of TNF-alpha associated with necrosis and cancer
4) Confidence 0.68 Published 2009 Journal Phytother Res Section Abstract Doc Link 19067390 Disease Relevance 1.08 Pain Relevance 0.61
Surprisingly, unilateral CCI of the sciatic nerve induced significant bilateral changes in the level of TNF-?
Transcription (level) of TNF in sciatic nerve associated with eae and sciatic nerve
5) Confidence 0.67 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2828436 Disease Relevance 0.60 Pain Relevance 0.41
Expression of mRNA for tumor necrosis factor alpha (TNF-?)
Transcription (Expression) of TNF associated with necrosis and cancer
6) Confidence 0.67 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2933434 Disease Relevance 0.47 Pain Relevance 0.14
Baseline level of TNF-?
Transcription (level) of TNF
7) Confidence 0.67 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2828436 Disease Relevance 1.03 Pain Relevance 1.01
Cromolyn Sodium (CS) is a mast cell membrane stabilizer, it can inhibit the mast cell de-granulation and releasing of histamine, TNF-?
Transcription (granulation) of TNF in mast cell
8) Confidence 0.67 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2564972 Disease Relevance 0.99 Pain Relevance 0.23
Additionally, mRNA and protein (IL-1beta and TNF-alpha) levels of the pro-inflammatory cytokines IL-1alpha, IL-1beta and TNF-alpha were elevated in COR rats compared with INT and ADX rats.
Transcription (levels) of TNF-alpha associated with inflammation and cytokine
9) Confidence 0.66 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12562515 Disease Relevance 0.85 Pain Relevance 0.47
Additionally, mRNA and protein (IL-1beta and TNF-alpha) levels of the pro-inflammatory cytokines IL-1alpha, IL-1beta and TNF-alpha were elevated in COR rats compared with INT and ADX rats.
Transcription (levels) of TNF-alpha associated with inflammation and cytokine
10) Confidence 0.66 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12562515 Disease Relevance 0.85 Pain Relevance 0.47
The divergent organ pattern of TNFalpha transcription emphasizes the importance of its localized expression, which is critical to the understanding of its autocrine and paracrine actions in ischemia and reperfusion.
Transcription (transcription) of TNFalpha associated with ischemia
11) Confidence 0.64 Published 2001 Journal Shock Section Abstract Doc Link 11303732 Disease Relevance 0.53 Pain Relevance 0.32
TNFalpha mRNA was not detected in the intestine (the ischemic organ) and in the kidney, brain, heart, or liver after all 4 experimental protocols.
Neg (not) Transcription (detected) of TNFalpha in brain
12) Confidence 0.61 Published 2001 Journal Shock Section Abstract Doc Link 11303732 Disease Relevance 0.67 Pain Relevance 0.36
In addition, the mRNA levels of tumor necrosis factor-alpha (TNF-alpha), inducible nitric oxide synthase (iNOS) and heme oxygenase-1 (HO-1) were evaluated.
Transcription (levels) of tumor necrosis factor-alpha associated with necrosis and cancer
13) Confidence 0.55 Published 2003 Journal Arch. Pharm. Res. Section Abstract Doc Link 14723344 Disease Relevance 0.51 Pain Relevance 0.08
In addition, the mRNA levels of tumor necrosis factor-alpha (TNF-alpha), inducible nitric oxide synthase (iNOS) and heme oxygenase-1 (HO-1) were evaluated.
Transcription (levels) of TNF-alpha associated with necrosis and cancer
14) Confidence 0.55 Published 2003 Journal Arch. Pharm. Res. Section Abstract Doc Link 14723344 Disease Relevance 0.51 Pain Relevance 0.08
The IL-1beta, TNFalpha, and COX-1 mRNA were detected in intact and ulcerated gastric mucosa, whereas COX-2 mRNA were upregulated only in ulcerated mucosa with peak observed at day 3 after ulcer induction.
Transcription (detected) of TNFalpha associated with ulcers
15) Confidence 0.54 Published 2001 Journal Microsc. Res. Tech. Section Abstract Doc Link 11376495 Disease Relevance 0.94 Pain Relevance 0.18
One mM amygdalin significantly inhibited the expression of TNF-alpha and IL-1beta mRNAs in LPS-treated RAW 264.7 cells.
Transcription (expression) of TNF-alpha in RAW 264
16) Confidence 0.53 Published 2008 Journal J. Microbiol. Biotechnol. Section Abstract Doc Link 18955812 Disease Relevance 0.77 Pain Relevance 0.45
Experimental brain injury induces differential expression of tumor necrosis factor-alpha mRNA in the CNS.
Transcription (expression) of tumor necrosis factor-alpha in brain associated with necrosis, cancer and brain injury
17) Confidence 0.53 Published 1996 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 8965649 Disease Relevance 0.98 Pain Relevance 0.25
STME reduced levels of tumor necrosis factor-alpha, both mRNA and its protein, and significantly decreased IL-1beta and IL-6 production.
Transcription (levels) of tumor necrosis factor-alpha associated with necrosis and cancer
18) Confidence 0.53 Published 2008 Journal Pharmacology Section Abstract Doc Link 18818510 Disease Relevance 0.44 Pain Relevance 0.24
Urethan neither directly bound LPS by Limulus assay nor inhibited LPS-stimulated TNF-alpha mRNA expression in cultured mouse peritoneal macrophages, but TNF-alpha mRNA expression was suppressed by serum from a urethan-treated rat.
Transcription (expression) of TNF-alpha in peritoneal macrophages
19) Confidence 0.53 Published 1996 Journal J. Appl. Physiol. Section Abstract Doc Link 8941558 Disease Relevance 0.70 Pain Relevance 0.11
Urethan neither directly bound LPS by Limulus assay nor inhibited LPS-stimulated TNF-alpha mRNA expression in cultured mouse peritoneal macrophages, but TNF-alpha mRNA expression was suppressed by serum from a urethan-treated rat.
Transcription (expression) of TNF-alpha in peritoneal macrophages
20) Confidence 0.53 Published 1996 Journal J. Appl. Physiol. Section Abstract Doc Link 8941558 Disease Relevance 0.68 Pain Relevance 0.11

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox