INT66766

Context Info Confidence 0.06 First Reported 1996 Last Reported 1996 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.19 Pain Relevance 0.60

extracellular region (Casp1, Pla2g10) peptidase activity (Casp1) cell death (Casp1) nucleus (Casp1) intracellular (Casp1) protein complex (Casp1)

Casp1 (Rattus norvegicus) Pla2g10 (Rattus norvegicus)

Pain Link Frequency Relevance Heat aspirin 8 98.56 Inflammation 3 88.16 cytokine 2 87.12 cINOD 2 57.44

Disease Link Frequency Relevance Heat INFLAMMATION 4 73.64

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, by electrophoretic mobility shift analysis we demonstrate reduced DNA binding of the nuclear factor kappaB, an essential component of the IL-1beta-dependent upregulation of sPLA2 gene transcription, after treatment of the cells with aspirin.

IL-1beta-dependent Positive_regulation (upregulation) of Transcription (transcription) of sPLA2 associated with aspirin

1) Confidence 0.06 Published 1996 Journal FEBS Lett. Section Abstract Doc Link 8941724 Disease Relevance 0.19 Pain Relevance 0.60

General Comments

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