INT66792

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Context Info
Confidence 0.16
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 4.93
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (TPSAB1) extracellular space (TPSAB1) extracellular region (TPSAB1)
Anatomy Link Frequency
endothelium 2
smooth muscle cell 1
TPSAB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 8 100.00 Very High Very High Very High
Inflammation 74 99.84 Very High Very High Very High
aspirin 12 97.80 Very High Very High Very High
agonist 55 95.40 Very High Very High Very High
Angina 2 92.88 High High
Pain 2 92.32 High High
COX-2 inhibitor 1 81.28 Quite High
antagonist 19 79.60 Quite High
palliative 2 78.08 Quite High
Arthritis 10 34.24 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 87 99.84 Very High Very High Very High
Anaphylaxis 106 99.58 Very High Very High Very High
Adhesions 14 99.40 Very High Very High Very High
Urticaria 6 96.00 Very High Very High Very High
Cancer 44 93.20 High High
Cv General 3 Under Development 2 92.88 High High
Pain 2 92.32 High High
Systemic Mastocytosis 1 91.68 High High
Metastasis 8 90.72 High High
Mastocytosis 1 87.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The concomitant increased formation of 8-iso-PGF2alpha, one of the most abundant F2-isoprostanes in humans, generated by free-radical catalyzed arachidonate peroxidation, may be involved in aspirin resistance because of its capacity to induce platelet and vascular smooth muscle cell activation through the interaction with thromboxane receptors (TPs).
TPs Binding (interaction) of in smooth muscle cell associated with aspirin
1) Confidence 0.16 Published 2003 Journal Thromb. Res. Section Abstract Doc Link 14592549 Disease Relevance 0.31 Pain Relevance 0.61
Gastrointestinal signs and symptoms in anaphylaxis also have a greater association with histamine than with tryptase elevations [30].
tryptase Binding (association) of associated with anaphylaxis
2) Confidence 0.12 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2873621 Disease Relevance 1.19 Pain Relevance 0
Agreement over expected patient progress was relatively low, with TPs giving more optimistic prognoses than GPs (GP–TP ?
TPs Binding (low) of
3) Confidence 0.06 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2892346 Disease Relevance 0.63 Pain Relevance 0
At follow-up, patient progress was judged as ‘perfect’ or ‘better’ in most cases (80, 90 and 90% according to GPs, TPs and patient, respectively).
TPs Binding (according) of
4) Confidence 0.06 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2892346 Disease Relevance 0.54 Pain Relevance 0.08
PAR2 is activated by mainly serine proteases (e.g. trypsin, tryptase, cathepsin G) but not thrombin and may be linked to inflammatory and proliferative disorders [4].
tryptase Binding (linked) of associated with inflammation
5) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.70 Pain Relevance 0.24
PAR2 is activated by mainly serine proteases (e.g. trypsin, tryptase, cathepsin G) but not thrombin and may be linked to inflammatory and proliferative disorders [4].
tryptase Binding (thrombin) of associated with inflammation
6) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.68 Pain Relevance 0.24
It has previously been reported that sickle reticulocytes express the alpha 4 beta 1 integrin receptor and bind to cytokine-activated endothelium via an alpha 4 beta 1/vascular-cell adhesion molecule-1 (VCAM-1) interaction.
alpha 4 beta 1 Binding (bind) of in endothelium associated with adhesions and cytokine
7) Confidence 0.00 Published 1996 Journal Blood Section Abstract Doc Link 8943872 Disease Relevance 0.44 Pain Relevance 0.14
It has previously been reported that sickle reticulocytes express the alpha 4 beta 1 integrin receptor and bind to cytokine-activated endothelium via an alpha 4 beta 1/vascular-cell adhesion molecule-1 (VCAM-1) interaction.
alpha 4 beta 1 Binding (bind) of in endothelium associated with adhesions and cytokine
8) Confidence 0.00 Published 1996 Journal Blood Section Abstract Doc Link 8943872 Disease Relevance 0.44 Pain Relevance 0.14

General Comments

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