INT66925

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Context Info
Confidence 0.15
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 10.47
Pain Relevance 6.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ik)
Anatomy Link Frequency
adipocytes 6
T cells 4
liver 2
smooth muscle 2
splenic macrophages 2
Ik (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 523 100.00 Very High Very High Very High
Inflammation 379 99.84 Very High Very High Very High
Neurotransmitter 7 99.30 Very High Very High Very High
Arthritis 96 98.92 Very High Very High Very High
Morphine 157 98.72 Very High Very High Very High
Paracetamol 2 98.48 Very High Very High Very High
Inflammatory mediators 35 98.16 Very High Very High Very High
rheumatoid arthritis 97 97.50 Very High Very High Very High
Inflammatory stimuli 4 94.56 High High
chemokine 41 91.16 High High
Disease Link Frequency Relevance Heat
Disease 144 99.86 Very High Very High Very High
Obesity 489 99.84 Very High Very High Very High
INFLAMMATION 460 99.84 Very High Very High Very High
Targeted Disruption 46 99.64 Very High Very High Very High
Insulin Resistance 16 99.24 Very High Very High Very High
Arthritis 130 98.92 Very High Very High Very High
Rheumatoid Arthritis 97 97.50 Very High Very High Very High
Sprains And Strains 21 97.44 Very High Very High Very High
Injury 24 97.36 Very High Very High Very High
Body Weight 2 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the relative contribution of each of these mechanisms and their possible interplay are still somewhat controversial and might depend on the type of blood vessel and stimulation, a considerable consensus has been reached that the initial step of EDHF-dependent relaxation is the activation of SK (in particular SK3) and IK channels in the endothelium (reviewed in [177–179]), as supported also by findings in genetically modified mice overexpressing or lacking SK3 [181] or lacking IK channels [182].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of IK in blood vessel
1) Confidence 0.15 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.17 Pain Relevance 0
The biophysical characterization in heterologous expression systems showed the voltage independence of SK and IK channels and a half maximal activation by ?
Positive_regulation (independence) of Gene_expression (channels) of IK
2) Confidence 0.15 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0.03
Two hours thereafter, peritoneal (pMphi) and splenic macrophages (sMphi) were harvested and assessed not only for their ability to release IL-1 and IL-6, but also for cytokine gene expression using semiquantitative reverse transcription and PCR.
Positive_regulation (assessed) of Gene_expression (expression) of cytokine in splenic macrophages associated with cytokine
3) Confidence 0.04 Published 1996 Journal J. Immunol. Section Abstract Doc Link 8955229 Disease Relevance 0.60 Pain Relevance 0.33
For intracellular cytokine staining, splenocytes were incubated for 5 hours at 37°C in RP10 (RPMI with 10% FBS, 10 mM HEPES, 4 mM L-Glutamine, 100 U/ml penicilin, 100 µg/mL streptomycin, 50 µM ?
Positive_regulation (incubated) of Gene_expression (staining) of cytokine associated with cytokine
4) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.07 Pain Relevance 0.08
IDelayed is a composite current, consisting of residual IA, non-inactivating IK,v, and IK(Ca) (Alkon et al., 1984; Farley, 1988; Farley and Wu, 1989; Jin et al., 2009).
Positive_regulation (inactivating) of Gene_expression (al.) of IK
5) Confidence 0.03 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2928666 Disease Relevance 0 Pain Relevance 0
A recent paper elegantly addressed this question by using the drd1a promoter to drive the expression of tdTomato, a red fluorescent protein, in BAC transgenic mice [21].
Positive_regulation (drive) of Gene_expression (expression) of red fluorescent protein associated with targeted disruption
6) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651623 Disease Relevance 0.22 Pain Relevance 0.12
Recent evidence indicates that the upregulated expression of cytokines and cytokine receptors may be involved.
Positive_regulation (upregulated) of Gene_expression (expression) of cytokine associated with cytokine
7) Confidence 0.02 Published 2004 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 15321784 Disease Relevance 0.33 Pain Relevance 0.42
This is a frequently used method for inducing cytokine production by specific T-lymphocyte clones [27].
Positive_regulation (inducing) of Gene_expression (production) of cytokine in T-lymphocyte associated with cytokine
8) Confidence 0.02 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.16 Pain Relevance 0.15
SOCS3 mRNA up-regulation in the COX-2 deficient mice can thus be viewed as the consequence of the higher cytokine production in these mice after LPS.
Positive_regulation (higher) of Gene_expression (production) of cytokine associated with cytokine
9) Confidence 0.01 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.61 Pain Relevance 0.47
IL-33 itself has been shown to be a potent inducer of mast cell cytokine production [15], [16], [17], [38], independent of Fc?
Positive_regulation (inducer) of Gene_expression (production) of cytokine in mast cell associated with cytokine
10) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0 Pain Relevance 0.09
The depressed TH2 response we suggest to be a result of smooth muscle cells being unable to react effectively to the key smooth muscle contraction amplifying cytokine IL-13 and the neurotransmitter acetylcholine [6] sufficiently to stimulate rapid cytokine production in the MLNs.
Positive_regulation (stimulate) of Gene_expression (production) of cytokine in smooth muscle associated with neurotransmitter and cytokine
11) Confidence 0.01 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.36 Pain Relevance 0.27
Furthermore, DNA released from necrotic hepatocytes stimulates cytokine synthesis via activation of TLR9 during murine acetaminophen-induced liver injury [122].
Positive_regulation (stimulates) of Gene_expression (synthesis) of cytokine in liver associated with paracetamol, injury and cytokine
12) Confidence 0.01 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 1.17 Pain Relevance 0.40
, IL-6, and IL-17 are suppressed in MDL-1–Ig fusion protein–treated mice, whereas the anti–MDL-1–treated group show enhanced cytokine gene expression (Fig. 5 A).
Positive_regulation (enhanced) of Gene_expression (expression) of cytokine associated with cytokine
13) Confidence 0.01 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.40 Pain Relevance 0.29
B-induced cytokine production in astrocytes treated with Tat±morphine.
Positive_regulation (induced) of Gene_expression (production) of cytokine in astrocytes associated with morphine and cytokine
14) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.07 Pain Relevance 0.59
B is necessary for sustained cytokine transcription and expression.
Positive_regulation (necessary) of Gene_expression (expression) of cytokine associated with cytokine
15) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.06 Pain Relevance 0.86
In bone fide inflammatory cells, cytokine gene expression is activated following activation of the Nuclear Factor-kappaB (NF-?
Positive_regulation (activated) of Gene_expression (expression) of cytokine associated with inflammation and cytokine
16) Confidence 0.01 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2441623 Disease Relevance 1.21 Pain Relevance 0.34
Comparison of the effectiveness of several ATP analogs suggests that the P2Y11 receptor is responsible for enhancing cytokine expression [62].
Positive_regulation (enhancing) of Gene_expression (expression) of cytokine associated with cytokine
17) Confidence 0.01 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0.07 Pain Relevance 0.45
Separately, but perhaps in a related finding, it was found that T cells generate microparticles that can promote cytokine production in macrophages [156].
Positive_regulation (promote) of Gene_expression (production) of cytokine in T cells associated with cytokine
18) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 0.66 Pain Relevance 0.31
Rheumatoid arthritis (RA) and its accepted animal model, murine collagen-induced arthritis (CIA), are classic autoimmune inflammatory diseases which require proinflammatory cytokine production for pathogenesis.
Positive_regulation (require) of Gene_expression (production) of cytokine associated with inflammation, rheumatoid arthritis, disease, cytokine and arthritis
19) Confidence 0.00 Published 2007 Journal BMC Complement Altern Med Section Abstract Doc Link PMC1899520 Disease Relevance 0.80 Pain Relevance 0.40
has pleiotropic effects on adipocyte physiology including an induction of lipolysis to increase the mobilization of free fatty acids [46,47], activating cytokine expression [8] and promoting insulin resistance [5,48].
Positive_regulation (activating) of Gene_expression (expression) of cytokine in adipocyte associated with insulin resistance and cytokine
20) Confidence 0.00 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2441623 Disease Relevance 1.38 Pain Relevance 0.25

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