INT67048

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Context Info
Confidence 0.75
First Reported 1996
Last Reported 2010
Negated 4
Speculated 2
Reported most in Body
Documents 58
Total Number 67
Disease Relevance 28.93
Pain Relevance 10.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGA4) plasma membrane (ITGA4)
Anatomy Link Frequency
oocytes 6
neurons 6
brain 3
embryonic kidney 2
leukocytes 2
ITGA4 (Homo sapiens)
Pain Link Frequency Relevance Heat
mu opioid receptor 24 100.00 Very High Very High Very High
Nav1.7 111 99.96 Very High Very High Very High
sodium channel 51 99.96 Very High Very High Very High
Opioid 14 99.92 Very High Very High Very High
Hippocampus 7 99.84 Very High Very High Very High
dorsal root ganglion 85 99.82 Very High Very High Very High
hyperexcitability 30 99.58 Very High Very High Very High
potassium channel 22 99.46 Very High Very High Very High
antagonist 53 99.38 Very High Very High Very High
GABAergic 4 98.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 3 100.00 Very High Very High Very High
Infection 77 99.92 Very High Very High Very High
Familial Dysautonomia 600 99.86 Very High Very High Very High
Pancreatic Cancer 6 99.84 Very High Very High Very High
Ganglion Cysts 91 99.82 Very High Very High Very High
Targeted Disruption 14 99.80 Very High Very High Very High
Wound Healing 1 99.80 Very High Very High Very High
Virus Diseases 89 99.72 Very High Very High Very High
Death 24 99.72 Very High Very High Very High
Endometriosis 10 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Many of these cells also express LFA-1 (CD11a/CD18), Mac-1 (CD11b/CD18), and VLA-4 (CD49d/CD29) on their surfaces.
Gene_expression (express) of CD49d
1) Confidence 0.75 Published 2001 Journal Semin Dial Section Abstract Doc Link 11264784 Disease Relevance 0.81 Pain Relevance 0.12
We found that the beta4 integrin subunit protein was overexpressed in the majority of pancreatic carcinoma cases tested, whereas chronic pancreatitis and normal pancreas did not display substantial levels of expression.
Gene_expression (overexpressed) of beta4 integrin subunit protein in pancreas associated with pancreatic cancer and chronic pancreatitis
2) Confidence 0.64 Published 2005 Journal J. Histochem. Cytochem. Section Abstract Doc Link 15928331 Disease Relevance 0.54 Pain Relevance 0.20
The expression of the beta4 integrin subunit protein in pancreatic cancer was investigated using routine immunohistochemical methods on paraffin-embedded archival material.
Spec (investigated) Gene_expression (expression) of beta4 integrin subunit protein associated with pancreatic cancer
3) Confidence 0.64 Published 2005 Journal J. Histochem. Cytochem. Section Abstract Doc Link 15928331 Disease Relevance 0.39 Pain Relevance 0.13
Here, we analyse, by fluorescence recovery after photobleaching measurements, the lateral diffusion of fully functional T7-EGFP-hMOP receptors in neuroblastoma SH-SY5Y cells naturally expressing a low level of the wild-type receptor.
Gene_expression (expressing) of wild-type receptor in SH-SY5Y associated with neuroblastoma
4) Confidence 0.56 Published 2006 Journal FEBS Lett. Section Abstract Doc Link 16963028 Disease Relevance 0.17 Pain Relevance 0.12
Both series are highly selective for VLA-4 versus against other integrin family members.
Gene_expression (selective) of VLA-4
5) Confidence 0.51 Published 2004 Journal Curr Top Med Chem Section Abstract Doc Link 15544540 Disease Relevance 0.42 Pain Relevance 0.14
Immunohistochemical detection of the beta4 integrin subunit in pancreatic adenocarcinoma.
Gene_expression (detection) of beta4 integrin subunit associated with adenocarcinoma
6) Confidence 0.50 Published 2005 Journal J. Histochem. Cytochem. Section Title Doc Link 15928331 Disease Relevance 0.44 Pain Relevance 0.16
The major PBL subset attached was the CD3+, CD45RO+ memory T cell, with CD49d(high) expression.
Gene_expression (expression) of CD49d in PBL
7) Confidence 0.40 Published 1998 Journal Arthritis Rheum. Section Body Doc Link 9751102 Disease Relevance 0.05 Pain Relevance 0
Adipose tissue-derived stem cells are understood to express surface markers of CD9, CD10, CD13, CD29, CD44, CD49d, CD49e, CD54, CD55, CD59, CD73, CD90, CD105, CD146, CD166, and STRO-1, and lack hematopoietic lineage markers CD11b, CD14, CD19, CD34, and CD45 [20,34,50-53].
Neg (lack) Gene_expression (express) of CD49d in stem cells associated with obesity
8) Confidence 0.31 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0.17 Pain Relevance 0.06
Many of these cells also express LFA-1 (CD11a/CD18), Mac-1 (CD11b/CD18), and VLA-4 (CD49d/CD29) on their surfaces.
Gene_expression (express) of VLA-4
9) Confidence 0.26 Published 2001 Journal Semin Dial Section Abstract Doc Link 11264784 Disease Relevance 0.81 Pain Relevance 0.12
The microarray gene expression analysis of these cells indicates that the cells are negative for the hematopoietic markers CD34, CD49c, CD49d, CD62e, CD62p, CD106, CD117, CD133, CD235a, HLA-DRB4, HLA-DRB4 and HAS1, and positive for the mesenchymal markers CD13, CD29, CD44, CD49a/b, CD49e, CD73, CD105 and vimentin [18], supporting their USSCs/MSC origin.
Neg (negative) Gene_expression (negative) of CD49d
10) Confidence 0.24 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956109 Disease Relevance 0 Pain Relevance 0
1 1:6 (CD49d clone P4C2, CYTEL CORPORATION, San Diego, CA, USA) or incubated for two hours at room temperature with one of the following mAbs: mouse anti-human CXCR3 (clone 1C6), anti-CCR5 (clone 2D7), anti-CCR3 (clone 7B11), anti-CCL17/TARC (clone 2D8) at 10 ?
Gene_expression (clone) of CD49d in 1C6
11) Confidence 0.20 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0 Pain Relevance 0.07
Mass spectrometric analyses of TTR immunoprecipitated from serum showed the presence of both wild-type and variant proteins.
Gene_expression (presence) of wild-type
12) Confidence 0.14 Published 2007 Journal Amyloid Section Abstract Doc Link 17453626 Disease Relevance 0.47 Pain Relevance 0.10
Importantly, it has been recently shown that also recurrent seizures lead to chronic expression of VCAM-1, the ligand for VLA-4 integrin, potentially contributing to BBB permeability, neuroinflammation and brain damage potentially contributing to the evolution of chronic disease [10].
Gene_expression (expression) of VLA-4 integrin in brain associated with convulsion and chronic disease
13) Confidence 0.14 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2954970 Disease Relevance 2.03 Pain Relevance 0.21
We found decreased LFA-1 and VLA-4 on peripheral blood leukocytes in SCI patients and lower levels of CAMs in SCI patients with pressure ulcers than in those without them.
Gene_expression (found) of VLA-4 in blood associated with decubitus ulcers and frailty
14) Confidence 0.14 Published 1996 Journal Immunol. Res. Section Abstract Doc Link 8988397 Disease Relevance 0.90 Pain Relevance 0.08
We also show that ranolazine, at a clinically-relevant concentration, blocks high-frequency firing of DRG neurons expressing wild-type but not mutant channels.
Gene_expression (expressing) of wild-type in neurons
15) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link 20529343 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: Our data suggest that ranalozine can attenuate hyperexcitability of DRG neurons over-expressing wild-type Nav1.7 channels, as occurs in acquired neuropathic and inflammatory pain, and thus merits further study as an alternative to existing non-selective sodium channel blockers.


Gene_expression (expressing) of wild-type in neurons
16) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link 20529343 Disease Relevance 0 Pain Relevance 0
METHODS: The authors examined the inhibition of wild-type and mutant HERG channels, transiently expressed in Chinese hamster ovary cells by bupivacaine, ropivacaine, and mepivacaine.
Gene_expression (expressed) of wild-type in ovary
17) Confidence 0.09 Published 2005 Journal Anesthesiology Section Body Doc Link 15983462 Disease Relevance 0 Pain Relevance 0
To investigate a previous observation that classical antagonists behave as agonists at mutant H297N and H297Q mu opioid receptors, we compared the kinetics of recovery from opioids at wild-type and mutant mu receptors expressed in voltage-clamped Xenopus oocytes.
Gene_expression (expressed) of wild-type in oocytes associated with antagonist, mu opioid receptor, agonist and opioid
18) Confidence 0.08 Published 2000 Journal Synapse Section Abstract Doc Link 11020228 Disease Relevance 0 Pain Relevance 0.61
Kinetics of recovery from opioids at wild-type and mutant mu opioid receptors expressed in xenopus oocytes.
Gene_expression (expressed) of wild-type in oocytes associated with mu opioid receptor and opioid
19) Confidence 0.08 Published 2000 Journal Synapse Section Title Doc Link 11020228 Disease Relevance 0 Pain Relevance 0.79
Pharmacologic effects of the mutant channels were dominant when mutant and wild-type channels were coexpressed.
Gene_expression (coexpressed) of wild-type
20) Confidence 0.06 Published 2006 Journal Anesthesiology Section Body Doc Link 16931984 Disease Relevance 0.07 Pain Relevance 0

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