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Context Info
Confidence 0.54
First Reported 1996
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 47
Total Number 52
Disease Relevance 25.92
Pain Relevance 9.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (DST) endoplasmic reticulum (DST) cytoplasm (DST)
cell adhesion (DST) cell motility (DST) nucleus (DST)
Anatomy Link Frequency
plaque 4
PVH 2
spinal cord 2
DMH 2
neurons 2
DST (Homo sapiens)
Pain Link Frequency Relevance Heat
medulla 140 100.00 Very High Very High Very High
Cholecystokinin 208 99.86 Very High Very High Very High
parabrachial 19 99.68 Very High Very High Very High
amygdala 83 99.48 Very High Very High Very High
Kappa opioid receptor 50 99.36 Very High Very High Very High
Spinal cord 209 99.32 Very High Very High Very High
Pain 114 99.08 Very High Very High Very High
Neuropathic pain 110 98.92 Very High Very High Very High
Lasting pain 44 98.84 Very High Very High Very High
imagery 126 97.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 732 100.00 Very High Very High Very High
Atherosclerotic Plaque 110 100.00 Very High Very High Very High
Adhesions 5 99.72 Very High Very High Very High
Targeted Disruption 179 99.64 Very High Very High Very High
Hypothermia 112 99.40 Very High Very High Very High
Pain 158 99.08 Very High Very High Very High
Neuropathic Pain 187 98.92 Very High Very High Very High
Cardiovascular Disease 93 98.60 Very High Very High Very High
Recurrence 6 98.58 Very High Very High Very High
Diabetes Mellitus 129 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Higher BPA concentrations were also associated with diagnosed diabetes (OR per 1SD increase in BPA concentration?
Gene_expression (concentrations) of BPA associated with diabetes mellitus
1) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800195 Disease Relevance 0.44 Pain Relevance 0
Higher BPA concentrations in NHANES respondents were found to be associated with cardiovascular disease diagnoses (Odds Ratio (OR) per 1 standard deviation (SD) increase in BPA concentration?
Gene_expression (concentrations) of BPA associated with cardiovascular disease
2) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800195 Disease Relevance 0.42 Pain Relevance 0
Higher BPA concentrations in NHANES respondents were found to be associated with cardiovascular disease diagnoses (Odds Ratio (OR) per 1 standard deviation (SD) increase in BPA concentration?
Gene_expression (concentration) of BPA associated with cardiovascular disease
3) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800195 Disease Relevance 0.43 Pain Relevance 0
Bisphenol A (BPA) is a high production volume chemical widely used in food and drinks packaging.
Gene_expression (production) of BPA
4) Confidence 0.54 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2800195 Disease Relevance 0.25 Pain Relevance 0
More than 2.2 million metric tonnes of BPA are produced worldwide each year for use mainly as a constituent monomer in polycarbonate plastics, which are used extensively in drinks containers and food packaging, and in the production of epoxy resins used in the lining of canned goods [2].
Gene_expression (produced) of BPA
5) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800195 Disease Relevance 0 Pain Relevance 0
The DT-ANN produced by pairs of tones having frequencies ranging from 500 Hz to 3.5 kHz is largest in response to a DT of approximately 700-1100 Hz.
Gene_expression (produced) of DT-ANN
6) Confidence 0.37 Published 1996 Journal Hear. Res. Section Abstract Doc Link 8970823 Disease Relevance 0 Pain Relevance 0.06
16)Fewer than 10 patients in DST studies (n?
Gene_expression (studies) of DST
7) Confidence 0.29 Published 2010 Journal Journal of Psychopharmacology (Oxford, England) Section Body Doc Link PMC2951595 Disease Relevance 0.48 Pain Relevance 0
mg DST was used with a post-DEX cortisol cut-off for non-suppression of 138?
Gene_expression (used) of DST
8) Confidence 0.29 Published 2010 Journal Journal of Psychopharmacology (Oxford, England) Section Body Doc Link PMC2951595 Disease Relevance 0.62 Pain Relevance 0.04
5)Studies did not use the defined DST method (n?
Gene_expression (method) of DST
9) Confidence 0.29 Published 2010 Journal Journal of Psychopharmacology (Oxford, England) Section Body Doc Link PMC2951595 Disease Relevance 0.58 Pain Relevance 0
The reason for this increase remained unsolved, because no difference in patient-related plasma hemoglobin levels, serum gamma-GT, pre-albumin, or in DST was detected.
Neg (no) Gene_expression (detected) of DST in plasma
10) Confidence 0.26 Published 2010 Journal Crit Care Section Body Doc Link PMC2945119 Disease Relevance 0.88 Pain Relevance 0.04
Thus, DMH is made up of electrophysiologically similar neurons and PVN-projecting neurons are less excitable than neurons of unknown projection.
Gene_expression (made) of DMH in DMH
11) Confidence 0.21 Published 2003 Journal Brain Res. Section Abstract Doc Link 12967719 Disease Relevance 0 Pain Relevance 0.39
For lesioning the PVH or DMH, a glass micropipette (tip diameter, 50 µm) was inserted into the target area by using the same coordinates as for electrocoagulation.
Gene_expression (lesioning) of DMH
12) Confidence 0.16 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762328 Disease Relevance 0.21 Pain Relevance 0
In contrast, lesioning the DMH by ibotenic acid prevented LPS-induced cold-seeking behavior (P?
Gene_expression (lesioning) of DMH
13) Confidence 0.16 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762328 Disease Relevance 0.54 Pain Relevance 0.03
Yet, our data show that the involvement of DMH neurons and of PVH fibers of passage in cold-seeking behavior is specific to stimulation with a high dose of LPS.
Gene_expression (neurons) of DMH in neurons
14) Confidence 0.16 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762328 Disease Relevance 0.86 Pain Relevance 0.04
Although a direct projection of the DMH to the parabrachial nucleus was searched for, it was found upon close examination either nonexistent or weak [60]–[62].
Gene_expression (projection) of DMH in parabrachial nucleus associated with parabrachial
15) Confidence 0.16 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762328 Disease Relevance 0.45 Pain Relevance 0.10
Likewise, earlier reports of a direct projection of the DMH to the insular cortex [55] were not confirmed in subsequent studies using retrograde labeling [61], [63].
Gene_expression (projection) of DMH in insular cortex
16) Confidence 0.16 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762328 Disease Relevance 0.36 Pain Relevance 0.12
Lesioning the DMH with ibotenic acid, an excitotoxin that destroys neuronal bodies but spares fibers of passage, also prevented LPS-induced cold-seeking behavior; lesioning the PVH with ibotenate did not affect it.
Gene_expression (Lesioning) of DMH in PVH
17) Confidence 0.16 Published 2006 Journal PLoS ONE Section Abstract Doc Link PMC1762328 Disease Relevance 0.93 Pain Relevance 0.14
Excitotoxic lesions of PVH and DMH: effects on thermoregulation
Gene_expression (lesions) of DMH
18) Confidence 0.16 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762328 Disease Relevance 0.83 Pain Relevance 0.04
Most outputs from the SCN are directed at the subparaventricular zone (SPZ) and dorsomedial nucleus of the hypothalamus (DMH); in contrast, there is little innervation of the VLPO or orexin neurons [95,128].
Gene_expression (nucleus) of DMH in hypothalamus
19) Confidence 0.08 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701283 Disease Relevance 0 Pain Relevance 0
Essentially, BPA relies on the
Gene_expression (relies) of BPA
20) Confidence 0.06 Published 2008 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2648627 Disease Relevance 0.24 Pain Relevance 0

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