INT67116

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Context Info
Confidence 0.59
First Reported 1997
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 20
Total Number 23
Disease Relevance 7.64
Pain Relevance 8.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk3) plasma membrane (Ntrk3) response to stress (Ntrk3)
cytoplasm (Ntrk3)
Anatomy Link Frequency
neurons 5
sensory neurons 2
muscle 2
nerve 2
cell body 1
Ntrk3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 225 100.00 Very High Very High Very High
Neuropeptide 47 100.00 Very High Very High Very High
Somatostatin 20 100.00 Very High Very High Very High
Trk A 18 100.00 Very High Very High Very High
Calcitonin gene-related peptide 17 100.00 Very High Very High Very High
trk B 6 100.00 Very High Very High Very High
trk C 24 99.92 Very High Very High Very High
TRP channel 1 99.88 Very High Very High Very High
qutenza 84 99.84 Very High Very High Very High
Nerve growth factor 67 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 121 99.88 Very High Very High Very High
Contusions 31 99.74 Very High Very High Very High
Ganglion Cysts 210 99.08 Very High Very High Very High
Nociception 175 98.54 Very High Very High Very High
INFLAMMATION 91 97.92 Very High Very High Very High
Stress 20 97.28 Very High Very High Very High
Disease 2 96.12 Very High Very High Very High
Nervous System Injury 14 91.72 High High
Myalgia 20 88.80 High High
Arthritis 3 87.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Few, if any, pulpal afferents express the high-affinity neurotrophin-3 (NT3) receptor trkC, although many have large cell bodies typical of NT3-responsive sensory neurones.
Gene_expression (express) of trkC
1) Confidence 0.59 Published 2000 Journal Arch. Oral Biol. Section Abstract Doc Link 10739860 Disease Relevance 0.05 Pain Relevance 0.11
This has revealed a number of novel findings. tERK immunoreactivity is present in most dorsal root ganglion cells but is expressed most strongly in small (nociceptive) cells and, surprisingly, is absent in a population of large cells that expressed trkB or trkC but mainly lack p75(NTR) immunoreactivity.
Gene_expression (expressed) of trkC in dorsal root ganglion associated with nociception, ganglion cysts and dorsal root ganglion
2) Confidence 0.58 Published 2001 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 11520179 Disease Relevance 0.43 Pain Relevance 0.21
Therefore, we examined the effects of systemically administered capsaicin on the expression of the beta-preprotachykinin, gamma-preprotachykinin, somatostatin, calcitonin gene-related peptide, vasoactive intestinal polypeptide, galanin, neuropeptide Y and neurotrophin receptor family (trkA, trkB, trkC) genes in dorsal root ganglion neurons by in situ hybridization in adult rats.
Spec (examined) Gene_expression (expression) of trkC in neurons associated with ganglion cysts, qutenza, root ganglion neuron, neuropeptide, somatostatin and calcitonin gene-related peptide
3) Confidence 0.54 Published 1997 Journal Neuroscience Section Abstract Doc Link 8971780 Disease Relevance 0.17 Pain Relevance 0.78
Simultaneously, the number of trkA messenger RNA-expressing neurons also decreased to about 70% of the control level, while the number of neurons expressing trkB and trkC messenger RNAs was unaffected.
Gene_expression (expressing) of trkC in neurons
4) Confidence 0.54 Published 1997 Journal Neuroscience Section Abstract Doc Link 8971780 Disease Relevance 0.24 Pain Relevance 0.95
Here, (35)S-riboprobes were used to determine whether pulpal afferents of adult (2-month-old) rats express the nerve growth-factor (NGF) receptors, p75(NTR) and trkA, which are characteristic of peptidergic nociceptors, and additionally, whether these cells express receptors (trkB and trkC) for other members of the neurotrophin family.
Spec (whether) Gene_expression (express) of trkC in nociceptors associated with nociceptor
5) Confidence 0.51 Published 2000 Journal Arch. Oral Biol. Section Abstract Doc Link 10739860 Disease Relevance 0.24 Pain Relevance 0.35
None of these three TRP channels were coexpressed with TrkB or TrkC.
Gene_expression (coexpressed) of TrkC associated with trp channel
6) Confidence 0.50 Published 2005 Journal J. Comp. Neurol. Section Abstract Doc Link 16304633 Disease Relevance 0.60 Pain Relevance 0.75
In the naïve DRG, the expression of Nav1.1 and Nav1.6 was restricted to A-fiber neurons, and they were preferentially expressed by TrkC neurons, suggesting that proprioceptive neurons possess these channels.
Gene_expression (expressed) of TrkC in neurons associated with nav1.1 and nav1.6
7) Confidence 0.47 Published 2008 Journal J. Comp. Neurol. Section Abstract Doc Link 18615542 Disease Relevance 0.07 Pain Relevance 0.95
In the control animals, beta-preprotachykinin, gamma-preprotachykinin, calcitonin gene-related peptide, somatostatin, trkA, trkB and trkC messenger RNAs were found in about 30%, 30%, 40%, 10%, 40%, 5% and 20% of the lumbar dorsal root ganglion neurons, respectively.
Gene_expression (found) of trkC in neurons associated with ganglion cysts, root ganglion neuron, somatostatin and calcitonin gene-related peptide
8) Confidence 0.46 Published 1997 Journal Neuroscience Section Abstract Doc Link 8971780 Disease Relevance 0.19 Pain Relevance 0.81
To confirm that the observed changes in gene expression in the transection model are an accurate portrayal of the TPS neuronal response to contusion injury, the expression of 8 different proteins (Gap43, Hspb1, Gfra1, Ret, Casp3, Ntrk1, Ntrk2, and Ntrk3) were examined immunofluorescently in DTMR retrogradely labeled TPS neurons following a moderate spinal contusion injury (NYU Impactor; 25 mm, 10 g weight drop).
Gene_expression (expression) of Ntrk3 in neuronal associated with injury and contusions
9) Confidence 0.44 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2894843 Disease Relevance 0.94 Pain Relevance 0
No significant change in the expression of the neurotrophic factor receptors Ntk1 (Trk A), Ntk2 (Trk B) or Ntrk3 (Trk C) was seen in the microarray or PCR array analyses.
Gene_expression (expression) of Ntrk3 associated with trk c, trk a and trk b
10) Confidence 0.34 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2894843 Disease Relevance 0.35 Pain Relevance 0.30
They express TrkA immunoreactivity but not TrkC in adult mice and rats, though they express Trk C transiently during development [28].
Neg (not) Gene_expression (express) of TrkC associated with trk c
11) Confidence 0.32 Published 2005 Journal Mol Pain Section Body Doc Link PMC1308857 Disease Relevance 0.32 Pain Relevance 0.21
Thirdly, sensory neurons express BDNF receptors trkB, trkC and p75NTR [33], [34] which are essential for the internalization and axonal transport of BDNF.
Gene_expression (express) of trkC in sensory neurons associated with bdmf
12) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2246162 Disease Relevance 0.24 Pain Relevance 0.79
They express TrkA immunoreactivity but not TrkC in adult mice and rats, though they express Trk C transiently during development [28].
Neg (not) Gene_expression (express) of TrkC associated with trk c
13) Confidence 0.28 Published 2005 Journal Mol Pain Section Body Doc Link PMC1308857 Disease Relevance 0.32 Pain Relevance 0.21
Another population of ASIC3-containing cells are quite large, can express TrkC, but do not express parvalbumin; this is a pattern observed with some non-nociceptive mechanoreceptors, but may not be unique to them.


Gene_expression (express) of TrkC in mechanoreceptors associated with nociception
14) Confidence 0.25 Published 2005 Journal Mol Pain Section Body Doc Link PMC1308857 Disease Relevance 0.42 Pain Relevance 0.13
The neurons fall into at least two distinct subsets: 1) small to medium-size, TrkA- and CGRP-positive muscle afferents that lack P2X3 and can innervate small arteries; and 2) large neurons that lack parvalbumin and can express either TrkA or TrkC.
Gene_expression (express) of TrkC in muscle
15) Confidence 0.25 Published 2005 Journal Mol Pain Section Body Doc Link PMC1308857 Disease Relevance 0.20 Pain Relevance 0.13
They vary widely in cell diameter and express different growth factor receptors: 68% express TrkA, the receptor for nerve growth factor, and 25% express TrkC, the NT3 growth factor receptor.
Gene_expression (express) of TrkC in nerve associated with nerve growth factor
16) Confidence 0.25 Published 2005 Journal Mol Pain Section Abstract Doc Link PMC1308857 Disease Relevance 0.26 Pain Relevance 0.28
A minority (25%, 93/373) of ASIC3+ neurons co-expressed TrkC (Fig. 2B), a growth factor receptor used by many non-nociceptive mechanosensors [30].
Gene_expression (expressed) of TrkC in neurons associated with nociception
17) Confidence 0.25 Published 2005 Journal Mol Pain Section Body Doc Link PMC1308857 Disease Relevance 0.27 Pain Relevance 0.24
They vary widely in cell diameter and express different growth factor receptors: 68% express TrkA, the receptor for nerve growth factor, and 25% express TrkC, the NT3 growth factor receptor.
Gene_expression (express) of NT3 growth factor in nerve associated with nerve growth factor
18) Confidence 0.25 Published 2005 Journal Mol Pain Section Abstract Doc Link PMC1308857 Disease Relevance 0.27 Pain Relevance 0.28
Data here indicates that 25% of ASIC3-staining cells also express TrkC, a growth factor receptor generally associated with non-nociceptive mechanosensors [30] and most clearly proven present in muscle proprioceptors [32].
Gene_expression (express) of TrkC in muscle associated with nociception
19) Confidence 0.25 Published 2005 Journal Mol Pain Section Body Doc Link PMC1308857 Disease Relevance 0.52 Pain Relevance 0.21
Proprioceptors are among the sensory neurons that express TrkC [32].
Gene_expression (express) of TrkC in sensory neurons
20) Confidence 0.22 Published 2005 Journal Mol Pain Section Body Doc Link PMC1308857 Disease Relevance 0.34 Pain Relevance 0.28

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