INT67135

Context Info Confidence 0.10 First Reported 1996 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 6 Disease Relevance 3.20 Pain Relevance 0.94

cytosol (Gc) transport (Gc) extracellular space (Gc) extracellular region (Gc)

Anatomy Link Frequency muscle cell 1 muscle 1 Gc (Mus musculus)

Pain Link Frequency Relevance Heat Multiple sclerosis 246 98.72 Central nervous system 3 66.04 Inflammatory response 3 62.24 fibrosis 3 55.08 Demyelination 6 42.08 anesthesia 3 25.00 Inflammation 6 5.00 tolerance 5 5.00 intrathecal 4 5.00 Pain 3 5.00

Disease Link Frequency Relevance Heat Immunization 1 100.00 Muscle Weakness 6 99.48 Cold Sores 2 99.32 Demyelinating Disease 252 98.72 Infection 1 98.08 Neurological Disease 4 86.64 Sprains And Strains 2 86.04 Disease 42 77.24 Mucopolysaccharidosis Vii 1 71.24 Mucopolysaccharidoses 1 70.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

More than 99% of 25-hydroxyvitamin D, the principle circulating metabolite of vitamin D is bound to proteins, of which approximately 90% is bound to vitamin D-binding protein [33], [34].

vitamin D-binding protein Binding (bound) of

1) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.17 Pain Relevance 0.47

Aberration of normal homeostasis of Vitamin D, of which approximately 90% is bound to vitamin D-binding protein, has been widely implicated in MScl for some years now.

vitamin D-binding protein Binding (bound) of associated with multiple sclerosis

2) Confidence 0.10 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2929207 Disease Relevance 0.75 Pain Relevance 0.37

The pathogenic effect of the vector virus in the mutants could be blocked by passive immunization with human gamma-globulin containing anti-HSV-1 antibodies on the day of infection but not when given at the peak of viral replication (day 4).

gamma-globulin Binding (immunization) of associated with cold sores, immunization and infection

3) Confidence 0.04 Published 1996 Journal J. Neurovirol. Section Abstract Doc Link 8972424 Disease Relevance 0.89 Pain Relevance 0.06

Vitamin D and calcium supplementation accounted for a 49% reduction in the risk of a fall (P?

Vitamin D Binding (accounted) of

4) Confidence 0.04 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0.12 Pain Relevance 0.03

Binding of vitamin D to its receptor results in the activation of several signaling pathways, including calcium uptake into the muscle cell, phosphate transport across the cell membrane, phospholipid metabolism, and muscle cell proliferation and differentiation [9••].

vitamin D Binding (Binding) of in muscle cell

5) Confidence 0.04 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0.06 Pain Relevance 0

During the past 10 to 20 years, many case reports have documented that in both young and old individuals, prolonged vitamin D deficiency can be associated with severe muscle weakness and disability and has been found to improve within several weeks of vitamin D supplementation [5, 6].

vitamin D Binding (associated) of in muscle associated with muscle weakness

6) Confidence 0.04 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0.22 Pain Relevance 0

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