INT67144

Context Info Confidence 0.76 First Reported 1996 Last Reported 2010 Negated 2 Speculated 3 Reported most in Body Documents 17 Total Number 21 Disease Relevance 8.94 Pain Relevance 4.48

cell adhesion (Cd44) plasma membrane (Cd44) nucleus (Cd44) protein complex (Cd44)

Anatomy Link Frequency monocytes 4 retina 1 spinal cord 1 joints 1 granulocytes 1 Cd44 (Rattus norvegicus)

Pain Link Frequency Relevance Heat fibrosis 58 99.92 Spinal cord 12 99.68 Inflammation 177 99.04 Chronic pancreatitis 11 98.72 Neuritis 16 98.68 chemokine 10 92.48 Inflammatory response 25 89.16 Sciatic nerve 2 85.40 Snapping jaw 7 83.04 Central nervous system 2 77.20

Disease Link Frequency Relevance Heat Fibrosis 62 99.92 Adenocarcinoma 24 99.84 Diabetes Mellitus 58 99.72 INFLAMMATION 214 99.04 Pancreatitis 12 98.72 Experimental Autoimmune Neuritis 16 98.68 Hyperplasia 10 97.00 Metastasis 13 95.32 Infection 28 94.36 Injury 22 81.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This study has investigated standard CD44 (CD44s) and CD44v6 expression immunohistochemically in 6 samples of normal pancreatic tissue, 4 of tissue affected by chronic pancreatitis, and 24 of tissue from metastasizing and nonmetastasizing pancreatic adenocarcinomas.

Spec (investigated) Gene_expression (expression) of CD44v6 associated with adenocarcinoma and chronic pancreatitis

1) Confidence 0.76 Published 1996 Journal Virchows Arch. Section Abstract Doc Link 8972753 Disease Relevance 0.78 Pain Relevance 0.16

Differential expression of CD44v6 in adenocarcinoma of the pancreas: an immunohistochemical study.

Gene_expression (expression) of CD44v6 in pancreas associated with adenocarcinoma

2) Confidence 0.76 Published 1996 Journal Virchows Arch. Section Title Doc Link 8972753 Disease Relevance 0.82 Pain Relevance 0.14

In contrast, CD44v6 was not detected in any of the normal tissue or chronic pancreatitis specimens, whereas 54% of pancreatic adenocarcinomas and 55% of metastases expressed this variant exon.

Neg (not) Gene_expression (detected) of CD44v6 associated with adenocarcinoma, chronic pancreatitis and metastasis

3) Confidence 0.76 Published 1996 Journal Virchows Arch. Section Abstract Doc Link 8972753 Disease Relevance 0.98 Pain Relevance 0.19

This study has investigated standard CD44 (CD44s) and CD44v6 expression immunohistochemically in 6 samples of normal pancreatic tissue, 4 of tissue affected by chronic pancreatitis, and 24 of tissue from metastasizing and nonmetastasizing pancreatic adenocarcinomas.

Spec (investigated) Gene_expression (expression) of CD44 associated with adenocarcinoma and chronic pancreatitis

4) Confidence 0.76 Published 1996 Journal Virchows Arch. Section Abstract Doc Link 8972753 Disease Relevance 0.79 Pain Relevance 0.16

Expression of CD44, a receptor of OPN, was weak in normal spinal cord tissue and increased in the entire spinal cord parenchyma in rats with EAN, as well as in inflammatory cells.

Gene_expression (Expression) of CD44 in spinal cord associated with inflammation, neuritis and spinal cord

5) Confidence 0.71 Published 2004 Journal J. Vet. Sci. Section Abstract Doc Link 15613811 Disease Relevance 0.88 Pain Relevance 1.14

These findings suggest that inflammatory cells as well as reactive astrocytes are major sources of OPN and CD44 in the spinal cord of rats with EAN.

Gene_expression (sources) of CD44 in astrocytes associated with inflammation, neuritis and spinal cord

6) Confidence 0.71 Published 2004 Journal J. Vet. Sci. Section Abstract Doc Link 15613811 Disease Relevance 0.93 Pain Relevance 1.14

In addition, the expression of CD44, of the integrin component CD18, and of MHC class II was determined.

Spec (determined) Gene_expression (expression) of CD44

7) Confidence 0.69 Published 2002 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 12030436 Disease Relevance 0.33 Pain Relevance 0.29

This localization pattern of CD44 and HABP might be involved in the formation of the epithelial arrangement of the synovial lining layer.

Gene_expression (pattern) of CD44

8) Confidence 0.56 Published 2006 Journal The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology Section Abstract Doc Link 16673425 Disease Relevance 0.30 Pain Relevance 0.22

CD44 is a widely expressed glycoprotein that plays a direct role in leukocyte trafficking to the retina [34].

Gene_expression (expressed) of CD44 in retina

9) Confidence 0.43 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2442612 Disease Relevance 0.82 Pain Relevance 0.30

Flow cytometry analysis showed that the positive incidence of CD29, CD44, and CD90 were 81.56%, 88.77%, and 98.43%, respectively, while the positive incidence of CD34, CD45, CD71, and CD133 were 0.10%, 0.17%, 10.02%, and 1.56%, respectively (Figure 1C).

Gene_expression (incidence) of CD44

10) Confidence 0.39 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905634 Disease Relevance 0 Pain Relevance 0

Cultivated MSCs were positive for CD29, CD44, and CD90, but negative for CD34, CD45, CD133, and CK12, with typical MSCs characteristics revealed by SEM.

Neg (negative) Gene_expression (negative) of CD44

11) Confidence 0.35 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2905634 Disease Relevance 0.16 Pain Relevance 0

CD44 and CD29 expressions were observed in 92% and 90%, respectively.

Gene_expression (expressions) of CD44

12) Confidence 0.30 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2799983 Disease Relevance 0 Pain Relevance 0

No significant modification in the expression of CD44 or in the percentage of CD25+ cells was evidenced in circulating granulocytes and lymphocytes (not shown).

Gene_expression (expression) of CD44 in granulocytes

13) Confidence 0.30 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2374764 Disease Relevance 0.11 Pain Relevance 0

These latter cells also exhibited an enhanced potential of extravasation ability, as suggested by increased expression of CD44 on their cellular membrane [18], as well as characteristics of activated monocytes [19,20], as indicated by the higher percentage of CD25+ cells in circulating monocytes, compared to the untreated control rats.

Gene_expression (expression) of CD44 in monocytes

14) Confidence 0.30 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2374764 Disease Relevance 0.22 Pain Relevance 0.08

The expression of CD44 and the percentage of CD25+ cells in circulating monocytes from treated and untreated rats were evaluated by cytofluorimetric analysis.

Gene_expression (expression) of CD44 in monocytes

15) Confidence 0.30 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2374764 Disease Relevance 0.09 Pain Relevance 0

Evaluation of CD44 expression and CD25+ cells in circulating monocytes

Gene_expression (expression) of CD44 in monocytes

16) Confidence 0.30 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2374764 Disease Relevance 0.09 Pain Relevance 0

Cytofluorimetric analysis showed that at T15 EO treatment induced a significant increase of the expression of CD44, as well as the percentage of CD25+ cells in circulating monocytes compared to the untreated control rats, and this effect also persisted at T20, after 5 days from the end of EO administration (Fig. 6e, f).

Gene_expression (expression) of CD44 in monocytes

17) Confidence 0.30 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2374764 Disease Relevance 0 Pain Relevance 0

In particular we evaluated the expression of CD44, the receptor for the extracellular matrix component hyaluronan that mediates the leukocyte/endothelial interactions leading to extravasation [18], and of CD25, a marker of circulating monocyte activation [19,20].

Gene_expression (expression) of CD44 in leukocyte

18) Confidence 0.30 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2374764 Disease Relevance 0 Pain Relevance 0

CD44, CTGF or iNOS expression was increased in the synovial lining of OA joints compared with normal, but there was no significant modulation of this increase by either HA preparation.

Gene_expression (expression) of CD44 in joints

19) Confidence 0.18 Published 2008 Journal Rheumatology (Oxford, England) Section Abstract Doc Link PMC2468886 Disease Relevance 0.53 Pain Relevance 0.21

CD44, a multivariate transmembrane glycoprotein known to be the principle cell surface receptor for HA [46], is present in the synovium [47] and SF [40] of OA patients and levels correlate with the degree of inflammation but not Kellgren grade [40].

Gene_expression (present) of CD44 in synovium associated with inflammation

20) Confidence 0.18 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468886 Disease Relevance 1.01 Pain Relevance 0.44

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