INT67156

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Context Info
Confidence 0.14
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.63
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGA4) plasma membrane (ITGA4)
Anatomy Link Frequency
macrophages 1
leukocyte 1
eosinophils 1
ITGA4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 1 99.24 Very High Very High Very High
antagonist 6 95.04 Very High Very High Very High
Opioid 1 92.84 High High
Inflammation 17 87.12 High High
cytokine 19 87.00 High High
cINOD 1 80.56 Quite High
mu opioid receptor 2 75.40 Quite High
sodium channel 3 75.04 Quite High
Acute pain 1 59.04 Quite High
local anesthetic 1 53.28 Quite High
Disease Link Frequency Relevance Heat
Adhesions 20 98.56 Very High Very High Very High
Epilepsy 66 96.96 Very High Very High Very High
Convulsion 55 93.44 High High
INFLAMMATION 14 87.12 High High
Disease 42 82.56 Quite High
Eosinophilia 27 79.48 Quite High
Gastritis 20 64.84 Quite High
Rhinitis 36 52.00 Quite High
Demyelinating Disease 55 50.00 Quite Low
Vomiting 22 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These observations have led to the suggestion that LW gp on erythroblasts may interact with VLA-4 on macrophages to stabilize erythroblastic islands in normal bone marrow and that Lu gp may facilitate trafficking of more mature erythroid cells to the sinusoidal endothelium where alpha 5-containing laminins are known to be expressed.
VLA-4 Binding (interact) of in macrophages
1) Confidence 0.14 Published 1999 Journal Baillieres Best Pract. Res. Clin. Haematol. Section Abstract Doc Link 10895261 Disease Relevance 0.23 Pain Relevance 0.06
Moreover, inhibition of BBB breakdown by blockade of leukocyte-endothelial interaction with an anti-VLA-4 antibody has preventive as well as therapeutic effects in a mouse model of epilepsy [10].
VLA-4 Binding (interaction) of in leukocyte associated with epilepsy
2) Confidence 0.09 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2954970 Disease Relevance 1.57 Pain Relevance 0.15
These bind corresponding ligands VLA-4 and LFA-1 respectively on eosinophils that leads to adhesion and transendothelial migration.
VLA-4 Binding (bind) of in eosinophils associated with adhesions
3) Confidence 0.02 Published 2004 Journal Clin Mol Allergy Section Body Doc Link PMC425596 Disease Relevance 0.72 Pain Relevance 0.24
In contrast to wild-type channels, which bind BTX almost irreversibly, toxin dissociation from mutant channels was rapid, but only when the channels were open, not when they were closed.
wild-type Binding (bind) of
4) Confidence 0.01 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 11901230 Disease Relevance 0 Pain Relevance 0.16
The molecule exhibits activity in a scintillation-proximity assay for the inhibition of the interaction between the integrin very-late antigen-4 (VLA-4; alpha 4 beta 1) and vascular-cell-adhesion molecule-1 (VCAM-1).
VLA-4 Binding (interaction) of associated with adhesions
5) Confidence 0.01 Published 1996 Journal Eur. J. Biochem. Section Abstract Doc Link 8973654 Disease Relevance 0.10 Pain Relevance 0.08
Binding of norbinaltorphimine (norBNI) congeners to wild-type and mutant mu and kappa opioid receptors: molecular recognition loci for the pharmacophore and address components of kappa antagonists.
wild-type Binding (Binding) of associated with antagonist and kappa opioid receptor
6) Confidence 0.00 Published 2000 Journal J. Med. Chem. Section Title Doc Link 10780914 Disease Relevance 0 Pain Relevance 0.34

General Comments

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