INT67341

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Context Info
Confidence 0.72
First Reported 1996
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 27
Total Number 29
Disease Relevance 30.46
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IGFBP3) extracellular region (IGFBP3) nucleus (IGFBP3)
Anatomy Link Frequency
plasma 6
fibroblasts 6
colon 2
hypothalamus 1
brain 1
IGFBP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 72 95.92 Very High Very High Very High
alcohol 54 91.32 High High
Clonidine 2 65.16 Quite High
anesthesia 3 53.36 Quite High
Angina 1 44.84 Quite Low
cINOD 18 42.20 Quite Low
cytokine 48 40.96 Quite Low
metalloproteinase 24 32.40 Quite Low
Analgesic 3 23.20 Low Low
Crohn's disease 18 16.72 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 1332 99.92 Very High Very High Very High
Cancer 237 99.64 Very High Very High Very High
Adhesions 762 99.44 Very High Very High Very High
Adenoma 846 99.40 Very High Very High Very High
Reprotox - General 1 21 98.76 Very High Very High Very High
Sleep Disorders 207 98.64 Very High Very High Very High
Stomach Cancer 18 97.80 Very High Very High Very High
Malignant Neoplastic Disease 105 97.68 Very High Very High Very High
Hypoxia 129 96.88 Very High Very High Very High
Growth Problems 8 96.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With the highest quartile as reference, low expression of IGFBP-3 mRNA in normal mucosa showed a positive association with risk of adenomas but the results did not reach statistical significance.
Transcription (expression) of IGFBP-3 associated with adenoma
1) Confidence 0.72 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 1.05 Pain Relevance 0.07
A recent study compared IGFBP-3 mRNA levels and protein localization in grossly normal versus nearby malignant colonic tissue from the same cancer patient [38].
Transcription (levels) of IGFBP-3 associated with malignant neoplastic disease and cancer
2) Confidence 0.72 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 1.10 Pain Relevance 0.03
In cancer tissue, however, IGFBP-3 mRNA was elevated and this reflected increased expression in the stroma but diminished or absent expression in malignant epithelium [15,38].
Transcription (elevated) of IGFBP-3 in epithelium associated with malignant neoplastic disease and cancer
3) Confidence 0.69 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 1.04 Pain Relevance 0
Surprisingly, we observed that low expression of IGFBP-3 mRNA in normal colon was associated with high apoptosis.
Transcription (expression) of IGFBP-3 in colon associated with apoptosis
4) Confidence 0.69 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 0.87 Pain Relevance 0
In the IGF-I generation test, after GH injection, the thalassaemic children had significantly lower IGF-I and IGFBP-3 levels 86.7 +/- 11.2 ng/ml and 2.05 +/- 0.51 mg/l respectively) than those in the CSS group (226 +/- 45.4 ng/ml and 2.8 +/- 0.43 mg/l respectively).
Transcription (had) of IGFBP-3 associated with growth problems
5) Confidence 0.64 Published 1998 Journal Eur. J. Endocrinol. Section Abstract Doc Link 9578506 Disease Relevance 0.61 Pain Relevance 0.07
Surprisingly, we did observe significant positive correlation between plasma IGFBP-3 and tissue IGFBP-3 mRNA expression.
Transcription (expression) of plasma IGFBP-3 in plasma
6) Confidence 0.63 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 1.60 Pain Relevance 0
Surprisingly, we did observe significant positive correlation between plasma IGFBP-3 and tissue IGFBP-3 mRNA expression.
Transcription (expression) of tissue IGFBP-3 in plasma
7) Confidence 0.63 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 1.58 Pain Relevance 0
1 in the normal peritoneal fibroblasts (Figure 3), whereas transcript levels of NID2, TM4SF1, and IGFBP3 were not altered by TGF-?
Transcription (levels) of IGFBP3 in fibroblasts
8) Confidence 0.62 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548295 Disease Relevance 0.76 Pain Relevance 0
Contrary to increase in the above mentioned mRNA species in the adhesion fibroblasts, steady state levels of IGFBP3 precursor transcript were found to be lower.
Transcription (transcript) of IGFBP3 in fibroblasts associated with adhesions
9) Confidence 0.62 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548295 Disease Relevance 0.99 Pain Relevance 0
Our findings that reduced expression of tissue IGFBP-3 mRNA in the normal colon is associated with increased risk of colorectal adenomas are compatible with evidence in experimental animal models indicating that elevated tissue IGFBP-3 protects against colon carcinogenesis [11].
Transcription (expression) of tissue IGFBP-3 in colon associated with adenoma
10) Confidence 0.60 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 0.99 Pain Relevance 0.04
Low expression of IGFBP-3 mRNA in normal colonic mucosa predicts increased risk of adenomas.
Transcription (expression) of IGFBP-3 associated with adenoma
11) Confidence 0.53 Published 2008 Journal BMC Cancer Section Abstract Doc Link PMC2409350 Disease Relevance 1.10 Pain Relevance 0
Surprisingly, local IGFBP-3 mRNA expression was inversely associated with apoptosis.


Transcription (expression) of IGFBP-3 associated with apoptosis
12) Confidence 0.53 Published 2008 Journal BMC Cancer Section Abstract Doc Link PMC2409350 Disease Relevance 1.17 Pain Relevance 0
Representative gels showing local IGFBP-3 mRNA expression in colonic biopsies are shown in Figure 1.
Transcription (expression) of IGFBP-3
13) Confidence 0.53 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 1.01 Pain Relevance 0.07
Local IGFBP-3 mRNA expression was inversely associated with apoptosis.
Transcription (expression) of IGFBP-3 associated with apoptosis
14) Confidence 0.53 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 1.74 Pain Relevance 0.03
Local IGFBP-3 mRNA expression, apoptosis and risk of colorectal adenomas

Background

Transcription (expression) of IGFBP-3 associated with adenoma and apoptosis
15) Confidence 0.53 Published 2008 Journal BMC Cancer Section Title Doc Link PMC2409350 Disease Relevance 0.82 Pain Relevance 0.05
In the study reported here, we evaluated the associations of plasma IGFBP-3, and local IGFBP-3 mRNA expression with colorectal adenomas or apoptosis in normal colonic mucosa.
Transcription (expression) of IGFBP-3 in plasma associated with adenoma and apoptosis
16) Confidence 0.53 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 1.00 Pain Relevance 0.04
Quantitative reverse transcription polymerase chain reaction (QRT-PCR) performed on de novo atherectomy specimens identified mRNA for IGF-I, IGF-I receptor, IGFBP-1, IGFBP-2, IGFBP-4, IGFBP-5 levels and detected mRNA for IGFBP-3.
Transcription (detected) of IGFBP-3
17) Confidence 0.49 Published 1996 Journal Regul. Pept. Section Abstract Doc Link 8988513 Disease Relevance 0 Pain Relevance 0
The semiquantitative RT-PCR experiments also confirmed lower expression levels of Insulin-like growth factor binding protein 3 precursor (IGFBP3) mRNA in the adhesion compared to normal peritoneal fibroblasts.
Transcription (levels) of IGFBP3 in fibroblasts associated with adhesions
18) Confidence 0.48 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548295 Disease Relevance 0.89 Pain Relevance 0
The semiquantitative RT-PCR experiments also confirmed lower expression levels of Insulin-like growth factor binding protein 3 precursor (IGFBP3) mRNA in the adhesion compared to normal peritoneal fibroblasts.
Transcription (expression) of IGFBP3 in fibroblasts associated with adhesions
19) Confidence 0.48 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548295 Disease Relevance 0.89 Pain Relevance 0
We also evaluated the association between plasma IGFBP-3 or tissue IGFBP-3 mRNA expression and apoptosis in the normal colonic mucosa (Table 4).
Transcription (expression) of tissue IGFBP-3 in plasma associated with apoptosis
20) Confidence 0.47 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 1.59 Pain Relevance 0.03

General Comments

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