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Context Info
Confidence 0.58
First Reported 1997
Last Reported 2011
Negated 1
Speculated 0
Reported most in Abstract
Documents 38
Total Number 38
Disease Relevance 26.18
Pain Relevance 3.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cd34) extracellular region (Cd34) cell motility (Cd34)
cell adhesion (Cd34) plasma membrane (Cd34) transcription factor binding (Cd34)
Anatomy Link Frequency
smooth muscle 7
blood 4
platelet 2
endothelial cells 1
neuron 1
Cd34 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 32 97.60 Very High Very High Very High
Analgesic 4 95.36 Very High Very High Very High
abdominal pain 11 93.84 High High
cerebral cortex 2 92.92 High High
Pain 24 91.04 High High
backache 1 88.24 High High
cva 23 87.84 High High
antagonist 1 87.32 High High
nud 1 86.04 High High
Inflammation 61 85.00 Quite High
Disease Link Frequency Relevance Heat
Multiple System Atrophy 1 100.00 Very High Very High Very High
Gastrointestinal Stromal Tumor 55 99.98 Very High Very High Very High
Skin Cancer 47 99.90 Very High Very High Very High
Cancer 228 99.78 Very High Very High Very High
Coronary Heart Disease 8 99.56 Very High Very High Very High
Hemangiosarcoma 17 99.52 Very High Very High Very High
Myocardial Infarction 26 98.64 Very High Very High Very High
Metastasis 57 98.04 Very High Very High Very High
Cv Unclassified Under Development 36 97.60 Very High Very High Very High
Malignant Neoplastic Disease 30 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LVL can be used to increase the CD34+ yield in patients with low CD34+ pre-counts.
Positive_regulation (increase) of CD34
1) Confidence 0.58 Published 2006 Journal Current stem cell research & therapy Section Abstract Doc Link 18220866 Disease Relevance 0.12 Pain Relevance 0
Large volume apheresis (LVL) with a processed volume of more than 4-fold of the patient's blood volume can be used to increase the CD34+ yield in patients with low CD34+ pre-counts, resulting in higher yields of CD34+ cells for transplantation.
Positive_regulation (increase) of CD34 in blood
2) Confidence 0.54 Published 2007 Journal Transfus. Apher. Sci. Section Abstract Doc Link 17980665 Disease Relevance 0.18 Pain Relevance 0.18
Reinfusion of a median of 1.6 x 10(6) activated CD34+ cells/kg resulted in the recovery of > 100/mm3 neutrophils and > 20,000 platelets by days 9 and 19, respectively, which was faster than our previous patients who received steady-state marrow, and comparable to our patients who received mobilized peripheral stem cells.
Positive_regulation (activated) of CD34 in platelets
3) Confidence 0.42 Published 1997 Journal Exp. Hematol. Section Abstract Doc Link 8989904 Disease Relevance 0 Pain Relevance 0
Induction of GAP-43 modulates neuroplasticity in PBSC (CD34+) implanted-Parkinson's model.
Positive_regulation (Induction) of CD34
4) Confidence 0.40 Published 2009 Journal J. Neurosci. Res. Section Title Doc Link 19235891 Disease Relevance 0.44 Pain Relevance 0.12
There was a negative association between impaired FMD and increased CD34(+) cell (r = -0.385, P < 0.05).
Positive_regulation (increased) of CD34
5) Confidence 0.39 Published 2005 Journal Zhonghua Xin Xue Guan Bing Za Zhi Section Body Doc Link 16563250 Disease Relevance 0.16 Pain Relevance 0
BACKGROUND: Several reports showed an increase of CD34(+) stem/progenitor cell count early after an acute myocardial infarction (AMI), suggesting a contribution of bone marrow cells in myocardial regeneration after the acute event.
Positive_regulation (increase) of CD34 in bone marrow associated with myocardial infarction
6) Confidence 0.38 Published 2006 Journal Int. J. Cardiol. Section Abstract Doc Link 16051386 Disease Relevance 0.41 Pain Relevance 0.09
Immunohistochemical study showed the tumor cells were strongly positive for CD34 and vimentin, but negative for epithelial membrane antigen.
Positive_regulation (positive) of CD34 associated with cancer
7) Confidence 0.38 Published 2000 Journal Neurol. Med. Chir. (Tokyo) Section Abstract Doc Link 11153198 Disease Relevance 0.88 Pain Relevance 0.08
Although they expressed CD29 and CD90, a majority of adherent cells were negative for CD34 and CD45, which is consistent with MSCs previously reported (8,21).


Positive_regulation (negative) of CD34
8) Confidence 0.35 Published 2008 Journal Diabetes Section Body Doc Link PMC2570407 Disease Relevance 0.48 Pain Relevance 0
Immunohistochemically the tumor cells are positive for Von-Willebrand factor, CD31, CD34 and vascular endothelial growth factor receptor-3 (VEGFR-3).
Positive_regulation (positive) of CD34 associated with cancer
9) Confidence 0.31 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1555613 Disease Relevance 0.76 Pain Relevance 0
Large volume apheresis (LVL) with a processed volume of more than 4-fold patient's blood volume is an approach to increase the CD34+ yield in patients with low CD34+ pre-counts resulting in higher yields of CD34+ cells for transplantation.
Positive_regulation (increase) of CD34 in blood
10) Confidence 0.29 Published 2008 Journal Transfus. Apher. Sci. Section Abstract Doc Link 18485822 Disease Relevance 0.09 Pain Relevance 0.23
By immunohistochemistry, in all cases, the endothelial cells lining the dilated lymphatic spaces were positive for CD31 and D2-40, 4 of 7 were positive for CD34, and all were negative for keratin.
Positive_regulation (positive) of CD34 in endothelial cells
11) Confidence 0.23 Published 2005 Journal Hum. Pathol. Section Abstract Doc Link 15892005 Disease Relevance 1.11 Pain Relevance 0.10
The histology revealed a GIST negative for CD34 but positive for CD117.
Positive_regulation (negative) of CD34 associated with gastrointestinal stromal tumor
12) Confidence 0.23 Published 2000 Journal Intern. Med. Section Abstract Doc Link 11065242 Disease Relevance 0.91 Pain Relevance 0.09
The histology revealed a GIST positive for both CD34 and CD117.
Positive_regulation (positive) of CD34 associated with gastrointestinal stromal tumor
13) Confidence 0.22 Published 2000 Journal Intern. Med. Section Abstract Doc Link 11065242 Disease Relevance 0.98 Pain Relevance 0.09
Immunohistochemical staining was positive for the endothelial markers CD31, CD34, CK(+), and vim(+).
Positive_regulation (positive) of CD34
14) Confidence 0.22 Published 2009 Journal J. Pediatr. Hematol. Oncol. Section Abstract Doc Link 19636267 Disease Relevance 0.76 Pain Relevance 0.09
Animal experimental evidence shows a significant increase of CD34+ (Burroughs et al 2005), being these results reproduced in human volunteers (Liles et al 2005; Flomenberg et al 2005).
Positive_regulation (increase) of CD34
15) Confidence 0.20 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721378 Disease Relevance 0.53 Pain Relevance 0.16
The tumor was composed of epithelioid cells, which showed positive staining for cytokeratin and expression of the common endothelial markers CD31, CD34, and von Willebrand factor.
Positive_regulation (staining) of CD34 associated with cancer
16) Confidence 0.16 Published 1999 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 10555012 Disease Relevance 0.85 Pain Relevance 0.08
In comparison, 10 localized fibrous tumors were immunohistochemically negative for keratin and epithelial membrane antigen and positive for CD34.
Positive_regulation (positive) of CD34 associated with cancer
17) Confidence 0.16 Published 2001 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 11395555 Disease Relevance 0.82 Pain Relevance 0.07
Treatment with G-CSF treatment was able to increase the blood levels of CD34+ cells in coronary disease patients (Suarez de Lezo et al 2005) with a related improvement in LVEF (Nienaber et al 2006), G-CSF treatment is able to increase CFU capability, although in vitro migration remained diminished (Honold et al 2006).
Positive_regulation (increase) of CD34 in blood associated with coronary heart disease
18) Confidence 0.15 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721378 Disease Relevance 0.23 Pain Relevance 0
Immunohistochemical analysis showed that the tumor cells were positive for c-kit and CD34, and the tumors were identified as intracranial metastasis of GIST.
Positive_regulation (positive) of CD34 associated with cancer, gastrointestinal stromal tumor and metastasis
19) Confidence 0.14 Published 2006 Journal Neurol. Med. Chir. (Tokyo) Section Abstract Doc Link 16723820 Disease Relevance 1.80 Pain Relevance 0.20
A single bolus of EPO has been shown to increase blood number of EPCs (CD34+/CD45?)
Positive_regulation (increase) of CD34 in blood
20) Confidence 0.14 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721378 Disease Relevance 0.66 Pain Relevance 0.12

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