INT67389

Context Info Confidence 0.45 First Reported 1996 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 7 Total Number 8 Disease Relevance 2.92 Pain Relevance 0.69

cytoskeleton (SGCA) cytoplasm (SGCA)

Anatomy Link Frequency heart 1 SGCA (Homo sapiens)

Pain Link Frequency Relevance Heat Clonidine 2 99.98 Inflammation 8 99.60 agonist 1 97.80 addiction 6 90.44 dysesthesia 1 90.32 continuous dysesthesia 1 86.56 Arthritis 16 81.52 Pain 20 51.84 Osteoarthritis 7 5.00 depression 4 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 11 99.60 Pneumonia 41 99.32 Disease 88 99.14 Myocardial Infarction 5 99.04 Lymphatic Filariasis 89 97.00 Bacterial Meningitis 2 91.76 Dysesthesia 2 90.32 Chronic Disease 40 87.12 Hydrocele 26 85.84 Influenza Virus Infection 3 85.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Clonidine increases membrane-associated phospholipase A 2.

Positive_regulation (increases) of A 2 associated with clonidine

1) Confidence 0.45 Published 2005 Journal Eur J Anaesthesiol Section Title Doc Link 16318667 Disease Relevance 0.19 Pain Relevance 0.34

Again, consistent with this, patients in our study showed significant increases in the KOOS ADL and Sport/Rec subscales from two weeks through to six weeks post-operatively.

Positive_regulation (increases) of ADL

2) Confidence 0.14 Published 2008 Journal Health Qual Life Outcomes Section Body Doc Link PMC2614963 Disease Relevance 0.10 Pain Relevance 0.05

Among subjects who died during the follow-up period, those who had reported low levels of ADL at the time of the initial survey had a greater proportion of deaths attributable to heart failure and pneumonia than those who had reported high levels of ADL.

Positive_regulation (levels) of ADL in heart associated with pneumonia and myocardial infarction

3) Confidence 0.12 Published 1996 Journal Nippon Koshu Eisei Zasshi Section Abstract Doc Link 8991499 Disease Relevance 0.45 Pain Relevance 0.18

The results of the study of ADL may have been influenced by co-morbidities and concurrent diseases; indeed, ASA-PS III/IV patients were more dependent in ADL, in both the ADLI and ADLP tasks.

Positive_regulation (dependent) of ADL associated with disease

4) Confidence 0.08 Published 2007 Journal BMC Anesthesiol Section Body Doc Link PMC1949812 Disease Relevance 0.10 Pain Relevance 0.05

Despite this greater severity and incapacitation of ADL, it is the lifelong disabling nature of the chronic conditions that makes LF such an economically crippling disease.

Positive_regulation (incapacitation) of ADL associated with lymphatic filariasis and disease

5) Confidence 0.06 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2879371 Disease Relevance 0.71 Pain Relevance 0

Comparison with studies in other countries is difficult due to use of different ADL measurements; however, narrowing ADL disability to receiving help for at least one of five ADL items (eating, bathing, dressing, transferring and toileting) or six ADL items (walking, eating, bathing, dressing, transferring and toileting) allows reasonable comparison across some studies.

Positive_regulation (narrowing) of ADL

6) Confidence 0.05 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2933720 Disease Relevance 0.06 Pain Relevance 0

Second, physical disability (10 item ADL, 6 item ADL, and 5 item ADL) and functional limitation increased with age, were more common in women than men and among Indians than among Malays and Chinese.

Positive_regulation (increased) of ADL

7) Confidence 0.04 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2933720 Disease Relevance 0.77 Pain Relevance 0.08

We defined a decline in functional status a priori as a 2-point increase on the ADL scale.

Positive_regulation (increase) of ADL

8) Confidence 0.01 Published 2006 Journal BMC Geriatr Section Body Doc Link PMC1557854 Disease Relevance 0.54 Pain Relevance 0

General Comments

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