INT67437

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Context Info
Confidence 0.47
First Reported 1997
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.23
Pain Relevance 2.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ifng) extracellular region (Ifng)
Anatomy Link Frequency
macrophages 2
Th1 cells 2
thymocytes 2
T cell 2
Ifng (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 9 99.80 Very High Very High Very High
Morphine 6 97.42 Very High Very High Very High
cytokine 15 97.36 Very High Very High Very High
Inflammation 5 96.96 Very High Very High Very High
narcan 2 94.64 High High
agonist 2 94.04 High High
Enkephalin 6 92.64 High High
Opioid 6 92.16 High High
Kappa opioid receptor 1 79.72 Quite High
opioid receptor 2 63.28 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 7 96.96 Very High Very High Very High
Injury 2 96.24 Very High Very High Very High
Cerebral Malaria 54 93.76 High High
Necrosis 1 87.68 High High
Cancer 2 87.32 High High
Syndrome 1 86.88 High High
Acute Liver Failure 1 85.56 High High
Infection 30 85.28 High High
Cv General 3 Under Development 7 84.04 Quite High
Immunization 2 79.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Only 10 mM U-50488 led to a decrease in nitrite release from interferon-gamma and LPS-stimulated macrophages.
Negative_regulation (decrease) of Localization (release) of interferon-gamma in macrophages
1) Confidence 0.47 Published 1998 Journal Neuropeptides Section Abstract Doc Link 10189065 Disease Relevance 0 Pain Relevance 1.04
Oncomice thymocytes cultured in the presence of Con A and cocaine showed a diminished release of sIL-2R and a lower secretion of IFN-gamma, a phenomenon not observed in FVB thymocytes.
Negative_regulation (diminished) of Localization (secretion) of IFN-gamma in thymocytes associated with cocaine
2) Confidence 0.37 Published 2001 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 11792019 Disease Relevance 0.23 Pain Relevance 0.42
Further, IFN-gamma release is suppressed by GA treatment [38,39].
Negative_regulation (suppressed) of Localization (release) of IFN-gamma
3) Confidence 0.25 Published 2009 Journal Malar J Section Body Doc Link PMC2651188 Disease Relevance 0.82 Pain Relevance 0.14
IL-10) are known to inhibit activation and proliferation of Th1 cells and the secretion of IFN-gamma, lysosomal enzymes and metalloproteinases.
Negative_regulation (inhibit) of Localization (secretion) of IFN-gamma in Th1 cells
4) Confidence 0.21 Published 2005 Journal Int J Cardiovasc Intervent Section Body Doc Link 16243737 Disease Relevance 0.17 Pain Relevance 0
Both motapizone as well as rolipram dose-dependently (0.1-10 mg/kg) attenuated the systemic release of TNF and interferon-gamma as initiated by injection of Con A (25 mg/kg) or SEB (2 mg/kg).
Negative_regulation (attenuated) of Localization (release) of interferon-gamma
5) Confidence 0.18 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8996181 Disease Relevance 0.64 Pain Relevance 0.09
As T cell receptor down-regulation or apoptosis after natural killer T cell activation and subsequent interferon-gamma release may contribute to atherogenesis, natural killer T cells can become a novel therapeutic target for the prevention and treatment of atherosclerotic vascular diseases.


Negative_regulation (down-regulation) of Localization (release) of interferon-gamma in T cell
6) Confidence 0.17 Published 2006 Journal Coron. Artery Dis. Section Body Doc Link 16905964 Disease Relevance 0.06 Pain Relevance 0
In this model, the exposure to morphine (25 mg/kg, 5 days before, during and 5 days after inoculation with the yeast) significant decreased IL-2 and IL-4 levels, while secretion of IFN-gamma was unaltered.
Negative_regulation (unaltered) of Localization (secretion) of IFN-gamma associated with morphine
7) Confidence 0.07 Published 2000 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 10737255 Disease Relevance 0.31 Pain Relevance 0.59

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