INT67611

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Context Info
Confidence 0.69
First Reported 1997
Last Reported 2009
Negated 1
Speculated 3
Reported most in Abstract
Documents 39
Total Number 42
Disease Relevance 18.33
Pain Relevance 13.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pparg) signal transduction (Pparg) nucleus (Pparg)
enzyme binding (Pparg) DNA binding (Pparg) cytoplasm (Pparg)
Anatomy Link Frequency
glial cells 3
macrophage 1
endothelial cells 1
stellate cell 1
TMJ 1
Pparg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 86 100.00 Very High Very High Very High
cytokine 10 100.00 Very High Very High Very High
COX2 3 100.00 Very High Very High Very High
agonist 169 99.96 Very High Very High Very High
Snapping jaw 16 99.90 Very High Very High Very High
cINOD 66 99.88 Very High Very High Very High
diclofenac 8 99.84 Very High Very High Very High
antagonist 20 99.70 Very High Very High Very High
cannabis 6 99.20 Very High Very High Very High
Antinociceptive 11 99.10 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 102 100.00 Very High Very High Very High
Temporomandibular Joint Syndrome 16 99.90 Very High Very High Very High
Parkinson's Disease 8 98.88 Very High Very High Very High
Apoptosis 4 98.84 Very High Very High Very High
Immunotherapy Of Cancer 1 98.80 Very High Very High Very High
Hyperinsulinism 8 98.68 Very High Very High Very High
Primary Sclerosing Cholangitis 2 98.68 Very High Very High Very High
Pancreatitis 3 98.56 Very High Very High Very High
Disease 35 98.46 Very High Very High Very High
Death 12 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results suggest that HCT1026 may exert additional anti-inflammatory actions through PPAR-gamma activation, allowing a more effective control of microglial activation and brain inflammation.
Positive_regulation (activation) of PPAR-gamma in brain associated with inflammation and encephalitis
1) Confidence 0.69 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15686492 Disease Relevance 0.33 Pain Relevance 0.42
Interestingly, unlike other NSAIDs that activate PPAR-gamma at concentrations higher than those required for cyclooxygenase inhibition, HCT1026 activated PPAR-gamma and inhibited prostaglandin E2 synthesis at the same low concentration (1 microm).
Positive_regulation (activate) of PPAR-gamma associated with cinod
2) Confidence 0.69 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15686492 Disease Relevance 0.25 Pain Relevance 0.56
It has been proposed that PPAR-gamma activation contributes to the potential benefits of the long-term use of certain NSAIDs in delaying the progression of Alzheimer's disease (AD).
Positive_regulation (activation) of PPAR-gamma associated with cinod and disease
3) Confidence 0.69 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15686492 Disease Relevance 0.36 Pain Relevance 0.41
We found that a low concentration (1 microm) of HCT1026, but not flurbiprofen, activated PPAR-gamma in primary cultures of rat microglia, with kinetics similar to those of the synthetic agonist ciglitazone.
Neg (not) Positive_regulation (activated) of PPAR-gamma in microglia associated with agonist
4) Confidence 0.69 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15686492 Disease Relevance 0.29 Pain Relevance 0.53
Finally, LXA(4) caused neuroprotection, which was partly inhibited by the PPARgamma antagonist T0070907, and increased PPARgamma transcriptional activity in isolated nuclei, showing for the first time that LXA(4) has PPARgamma agonistic actions.
Positive_regulation (increased) of PPARgamma associated with antagonist
5) Confidence 0.69 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19321784 Disease Relevance 0.67 Pain Relevance 0.29
The use of anti-inflammatory drugs for PD treatment has been proposed, and inhibition of cyclo-oxygenase-2 (COX-2) or activation of peroxisome proliferator-activated receptor gamma (PPAR-gamma) yields neuroprotection in MPTP-induced PD.
Positive_regulation (activation) of peroxisome proliferator-activated receptor gamma associated with parkinson's disease, inflammation, cinod and disease
6) Confidence 0.69 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17254027 Disease Relevance 1.33 Pain Relevance 0.53
The use of anti-inflammatory drugs for PD treatment has been proposed, and inhibition of cyclo-oxygenase-2 (COX-2) or activation of peroxisome proliferator-activated receptor gamma (PPAR-gamma) yields neuroprotection in MPTP-induced PD.
Positive_regulation (activation) of PPAR-gamma associated with parkinson's disease, inflammation, cinod and disease
7) Confidence 0.69 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17254027 Disease Relevance 1.34 Pain Relevance 0.54
Messenger RNA for PPARgamma was undetectable on day 1, low from days 5-14, and increased by day 19 pp (p < 0.05).
Positive_regulation (increased) of PPARgamma
8) Confidence 0.65 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2795759 Disease Relevance 0 Pain Relevance 0.03
These results suggest that activation of PPARgamma negatively regulate iNOS expression and positively regulates HO-1 expression in glial cells.
Positive_regulation (activation) of PPARgamma in glial cells
9) Confidence 0.63 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10203248 Disease Relevance 0.17 Pain Relevance 0.17
The peroxisome proliferator-activated receptor-gamma (PPARgamma) is activated by 15-deoxy-delta(12,14) prostaglandin J2 (15d-PGJ2), anti-diabetic thiazolidinediones and several non-steroidal anti-inflammatory drugs (NSAIDs).
Positive_regulation (activated) of PPARgamma associated with inflammation, diabetes mellitus and cinod
10) Confidence 0.63 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10203248 Disease Relevance 0.19 Pain Relevance 0.19
The peroxisome proliferator-activated receptor-gamma (PPARgamma) is activated by 15-deoxy-delta(12,14) prostaglandin J2 (15d-PGJ2), anti-diabetic thiazolidinediones and several non-steroidal anti-inflammatory drugs (NSAIDs).
Positive_regulation (activated) of peroxisome proliferator-activated receptor-gamma associated with inflammation, diabetes mellitus and cinod
11) Confidence 0.63 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10203248 Disease Relevance 0.19 Pain Relevance 0.19
Induction of cyclooxygenase-2 and peroxisome proliferator-activated receptor-gamma during nitric oxide-induced apoptotic PC12 cell death.
Positive_regulation (Induction) of peroxisome proliferator-activated receptor-gamma associated with cox2, apoptosis and death
12) Confidence 0.62 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Title Doc Link 15033806 Disease Relevance 1.21 Pain Relevance 0.21
Transcriptional activity of PPAR-gamma is induced by binding diverse ligands, including natural fatty acid derivatives, antidiabetic thiazolidinediones, and non-steroidal anti-inflammatory drugs.
Positive_regulation (induced) of PPAR-gamma associated with inflammation and cinod
13) Confidence 0.51 Published 1998 Journal Nature Section Abstract Doc Link 9845075 Disease Relevance 0.29 Pain Relevance 0.14
The PPAR-gamma antagonist GW9662 (2-chloro-5-nitrobenzanilide) prevented the activation of PPAR-gamma by HCT1026.
Positive_regulation (activation) of PPAR-gamma associated with antagonist
14) Confidence 0.50 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15686492 Disease Relevance 0.26 Pain Relevance 0.56
Interestingly, unlike other NSAIDs that activate PPAR-gamma at concentrations higher than those required for cyclooxygenase inhibition, HCT1026 activated PPAR-gamma and inhibited prostaglandin E2 synthesis at the same low concentration (1 microm).
Positive_regulation (activated) of PPAR-gamma associated with cinod
15) Confidence 0.50 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15686492 Disease Relevance 0.19 Pain Relevance 0.54
Furthermore, pharmacological inhibition and/or genetic deletion of 5-LO inhibited rosiglitazone-induced neuroprotection and downregulation of inflammatory gene expression, LXA(4) synthesis and PPARgamma transcriptional activity in rodents.
Positive_regulation (induced) of PPARgamma associated with inflammation
16) Confidence 0.50 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19321784 Disease Relevance 0.72 Pain Relevance 0.26
Synthesis of lipoxin A4 by 5-lipoxygenase mediates PPARgamma-dependent, neuroprotective effects of rosiglitazone in experimental stroke.
Positive_regulation (mediates) of PPARgamma associated with stroke
17) Confidence 0.50 Published 2009 Journal J. Neurosci. Section Title Doc Link 19321784 Disease Relevance 0.62 Pain Relevance 0.18
In conclusion, our data suggest an active role of PPARgamma in the induction of a quiescent PSC phenotype.
Positive_regulation (role) of PPARgamma associated with primary sclerosing cholangitis
18) Confidence 0.50 Published 2005 Journal J. Cell. Mol. Med. Section Abstract Doc Link 16202214 Disease Relevance 0.40 Pain Relevance 0
Thiazolidinediones (TZDs) are potent synthetic agonists of the ligand-activated transcription factor peroxisome proliferator-activated receptor-gamma (PPARgamma).
Positive_regulation (ligand-activated) of ligand-activated transcription factor peroxisome proliferator-activated receptor-gamma associated with agonist
19) Confidence 0.50 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17167171 Disease Relevance 0.84 Pain Relevance 0.42
Therefore, activation of PPARgamma prevented age-related deficits in hippocampal function.
Positive_regulation (activation) of PPARgamma
20) Confidence 0.50 Published 2004 Journal Neuroreport Section Abstract Doc Link 15371745 Disease Relevance 0.40 Pain Relevance 0.23

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