INT67656

Context Info Confidence 0.46 First Reported 1997 Last Reported 2010 Negated 1 Speculated 0 Reported most in Abstract Documents 12 Total Number 12 Disease Relevance 4.83 Pain Relevance 6.17

small molecule metabolic process (PTGS2) endoplasmic reticulum (PTGS2) enzyme binding (PTGS2) protein complex (PTGS2) cytoplasm (PTGS2) lipid binding (PTGS2)

Anatomy Link Frequency macrophages 2 TMJ 2 midbrain 2 nociceptor 2 PTGS2 (Homo sapiens)

Pain Link Frequency Relevance Heat COX2 11 100.00 cOX1 1 100.00 Inflammation 16 99.98 Kinase C 6 99.98 aspirin 26 99.94 analgesia 1 99.80 metalloproteinase 4 99.12 cytokine 4 99.08 midbrain 4 98.36 cINOD 30 98.20

Disease Link Frequency Relevance Heat Cancer 5 100.00 INFLAMMATION 25 99.98 Alzheimer's Dementia 4 99.02 Breast Cancer 2 98.76 Noninfiltrating Intraductal Carcinoma 3 96.52 Pain 7 95.24 Hypersensitivity 4 95.04 Post Operative Pain 1 91.64 Rheumatoid Arthritis 5 91.60 Fever 2 90.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Stimulation with STZ caused a time-dependent increase in levels of PGHS-2 mRNA; incubation with cytokine-suppressive agents caused a decrease of these levels, suggesting the involvement of transcription and/or mRNA stability events in the inhibition of PGHS-2.

Positive_regulation (caused) of Positive_regulation (increase) of PGHS-2 associated with cytokine

1) Confidence 0.46 Published 1997 Journal J. Immunol. Section Abstract Doc Link 9144511 Disease Relevance 0.07 Pain Relevance 0.24

As observed for the cyclooxygenase activity of PGHS-2, the inhibition of 15-HETE production by indomethacin was time-dependent for both ASA-PGHS-2 and PGHS-2(S516M).

Positive_regulation (observed) of Positive_regulation (activity) of PGHS-2 associated with aspirin

2) Confidence 0.46 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9016346 Disease Relevance 0.17 Pain Relevance 0.95

These results seem to suggest an importance for the caution that the enhanced induction of PGHS-2 protein and the concomitant release of PGs release would occur after removal of the NSAID not only from the medium in in vitro experiments but also from therapeutic prescription.

Positive_regulation (enhanced) of Positive_regulation (induction) of PGHS-2 protein associated with cinod

3) Confidence 0.43 Published 2004 Journal Biol. Pharm. Bull. Section Abstract Doc Link 15256727 Disease Relevance 0.13 Pain Relevance 0.73

Cyclooxygenase-2 induction after oral surgery does not entirely account for analgesia after selective blockade of cyclooxygenase 2 in the preoperative period.

Neg (not) Positive_regulation (account) of Positive_regulation (induction) of Cyclooxygenase-2 associated with cox2, cox1 and analgesia

4) Confidence 0.37 Published 2006 Journal Anesthesiology Section Title Doc Link 16394701 Disease Relevance 0.26 Pain Relevance 0.51

These results seem to suggest an importance for the caution that the enhanced induction of PGHS-2 protein and the concomitant release of PGs release would occur after removal of the NSAID not only from the medium in in vitro experiments but also from therapeutic prescription.

Positive_regulation (enhanced) of Positive_regulation (induction) of PGHS-2 protein associated with cinod

5) Confidence 0.31 Published 2004 Journal Biol. Pharm. Bull. Section Abstract Doc Link 15256727 Disease Relevance 0.13 Pain Relevance 0.73

Stimulation of U937 macrophages with LPS enhanced PGE(2) production in association with increased protein levels of cyclooxygenase-2 (COX-2).

Positive_regulation (enhanced) of Positive_regulation (increased) of cyclooxygenase-2 in macrophages

6) Confidence 0.22 Published 2010 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 20208419 Disease Relevance 0.56 Pain Relevance 0.36

Recent studies show that up-regulation of cyclooxygenase-2 (COX-2) in human cancer cells induces activation of matrix metalloproteinases (MMPs) and increase of metastatic potential.

Positive_regulation (induces) of Positive_regulation (up-regulation) of cyclooxygenase-2 associated with cancer and metalloproteinase

7) Confidence 0.19 Published 2001 Journal FEBS Lett. Section Abstract Doc Link 11728453 Disease Relevance 0.41 Pain Relevance 0.29

Amyloid beta peptide (25-35) activates protein kinase C leading to cyclooxygenase-2 induction and prostaglandin E2 release in primary midbrain astrocytes.

Positive_regulation (leading) of Positive_regulation (induction) of cyclooxygenase-2 in midbrain associated with kinase c, cox2 and midbrain

8) Confidence 0.15 Published 2006 Journal Neurochem. Int. Section Title Doc Link 16546299 Disease Relevance 0.68 Pain Relevance 0.75

RESULTS: Exposure of TMJ fibrochondrocytes to rHuIL-1beta resulted in the induction of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2), which were paralleled by NO and PGE2 production.

Positive_regulation (resulted) of Positive_regulation (induction) of cyclooxygenase 2 in TMJ

9) Confidence 0.15 Published 2001 Journal Arthritis Rheum. Section Body Doc Link 11263775 Disease Relevance 0 Pain Relevance 0

Epi-lipoxins (epi-LXs), for instance, are produced from aspirin's acetylation of inducible cyclooxygenase 2 (COX-2) and together with Resolvins represent an increasingly important family of immuno-regulatory and potentially cardio-protective lipid mediators.

Positive_regulation (acetylation) of Positive_regulation (inducible) of cyclooxygenase 2 associated with aspirin and cox2

10) Confidence 0.09 Published 2006 Journal ScientificWorldJournal Section Abstract Doc Link 16951898 Disease Relevance 0.63 Pain Relevance 0.81

The inducible prostaglandin synthase cyclooxygenase-2 (Cox-2) is overexpressed in approximately 40% of human breast cancers and at higher frequencies in preinvasive ductal carcinoma in situ (DCIS).

Positive_regulation (overexpressed) of Positive_regulation (inducible) of prostaglandin synthase cyclooxygenase-2 associated with breast cancer and noninfiltrating intraductal carcinoma

11) Confidence 0.06 Published 2005 Journal Cancer Res. Section Abstract Doc Link 16267038 Disease Relevance 0.74 Pain Relevance 0

Inflammation causes the induction of cyclooxygenase-2 (Cox-2), leading to the release of prostanoids, which sensitize peripheral nociceptor terminals and produce localized pain hypersensitivity.

Positive_regulation (causes) of Positive_regulation (induction) of cyclooxygenase-2 in nociceptor associated with inflammation, nociceptor, hypersensitivity and stimulus evoked pain

12) Confidence 0.02 Published 2001 Journal Nature Section Abstract Doc Link 11260714 Disease Relevance 1.05 Pain Relevance 0.79

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