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Context Info
Confidence 0.07
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.17
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Neu2) hydrolase activity, acting on glycosyl bonds (Neu2) cytoplasm (Neu2)
Anatomy Link Frequency
blood 1
plasma 1
Rat2 1
Neu2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
lidocaine 6 96.38 Very High Very High Very High
Bile 1 52.24 Quite High
transdermal 22 50.00 Quite Low
Glutamate 6 24.96 Low Low
fibrosis 2 20.72 Low Low
Inflammation 5 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 15 99.50 Very High Very High Very High
Necrosis 1 88.40 High High
Myocardial Infarction 29 88.24 High High
Cancer 2 88.04 High High
Hypertrophy 5 74.60 Quite High
Hepatotoxicity 1 70.00 Quite High
Disorders Of Creatine Metabolism 4 69.88 Quite High
Disease 1 60.80 Quite High
Body Weight Changes 3 59.12 Quite High
Death 4 56.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analysis of these different effects of lidocaine on the priming and full activation stages in the three protocols suggests the sequence of the underlying biochemical events of the two separate damage pathways associated with the release of cytosolic proteins and the degradation of the myofilament apparatus.
Localization (release) of cytosolic associated with lidocaine
1) Confidence 0.07 Published 1996 Journal Pathobiology Section Abstract Doc Link 9031331 Disease Relevance 0 Pain Relevance 0.48
In the present study, the prior administration of glutamine was found to significantly (p<0.001) reduce the release of the cytosolic enzymes into the systemic circulation, thereby demonstrating its cytoprotective action on the cell membranes.
Localization (release) of cytosolic
2) Confidence 0.01 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291504 Disease Relevance 0.29 Pain Relevance 0
They observed cytotoxicity of amine terminated G7, G5 and acetamide terminated G5 PAMAM dendrimers by release of cytosolic enzymes luciferase (Luc) and Lactase dehydrogenase (LDH) from KB and Rat2 cells.
Localization (release) of cytosolic enzymes luciferase in Rat2
3) Confidence 0.01 Published 2008 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2792561 Disease Relevance 0 Pain Relevance 0
In the present study, we have shown that aldosterone treatment induced overexpression of two membrane-bound elements (p22phox and gp91phox) and one cytosolic component (p47phox) of the NAD(P)H oxidase and its activity, and led to the translocation of the cytosolic p47phox to the plasma membrane in aorta and kidney.
Localization (translocation) of cytosolic in plasma
4) Confidence 0.01 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.31 Pain Relevance 0
Altered permeability of hepatocellular membrane caused by injury on liver results in the release of soluble cytosolic enzymes into blood.[11] They are generally escaped through basal-lateral side of hepatocytes facing the sinusoids which causing the elevation in blood.[12] Those enzymes are released into blood from the cytosol and subcellular organelles of hepatocytes once liver is injured or damaged.
Localization (release) of cytosolic in blood associated with injury
5) Confidence 0.01 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2900059 Disease Relevance 0.57 Pain Relevance 0.03

General Comments

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