INT67868

Context Info Confidence 0.43 First Reported 1997 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 18 Total Number 18 Disease Relevance 14.27 Pain Relevance 5.16

enzyme binding (Tgfb1) cytoplasm (Tgfb1) cell proliferation (Tgfb1) extracellular space (Tgfb1) extracellular region (Tgfb1) cell death (Tgfb1)

Anatomy Link Frequency dopaminergic neurons 4 macrophage 2 liver 2 mesothelial cells 2 carotid artery 2 Tgfb1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 187 100.00 cytokine 89 100.00 fibrosis 19 98.90 Chronic pancreatitis 25 98.60 lidocaine 102 95.68 Dopamine 6 92.64 Enkephalin 4 89.52 tolerance 17 85.36 alcohol 2 75.00 abdominal pain 1 72.64

Disease Link Frequency Relevance Heat INFLAMMATION 200 100.00 Disease 22 100.00 Parkinson's Disease 10 100.00 Carotid Stenosis 4 99.92 Ocular Injury 87 99.52 Renal Failure 6 99.44 Cirrhosis 8 99.30 Cicatrix 64 99.20 Fibrosis 19 98.90 Apoptosis 229 98.80

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Here, we show that overexpression of TGFbeta1, by recombinant adenovirus TGFbeta1 gene transfer, in the mesostriatal system of an MPTP mouse model of PD decreased the number of mesencephalic dopaminergic neurons.

Negative_regulation (decreased) of Gene_expression (transfer) of TGFbeta1 in dopaminergic neurons associated with parkinson's disease and disease

1) Confidence 0.43 Published 2003 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 12932441 Disease Relevance 0.79 Pain Relevance 0.22

Here, we show that overexpression of TGFbeta1, by recombinant adenovirus TGFbeta1 gene transfer, in the mesostriatal system of an MPTP mouse model of PD decreased the number of mesencephalic dopaminergic neurons.

Negative_regulation (decreased) of Gene_expression (overexpression) of TGFbeta1 in dopaminergic neurons associated with parkinson's disease and disease

2) Confidence 0.43 Published 2003 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 12932441 Disease Relevance 0.80 Pain Relevance 0.23

Sclerosing encapsulating peritonitis (SEP) is a serious complication of long-term continuous ambulatory peritoneal dialysis (CAPD), very likely related to a persisting expression of the transforming growth factor beta1 (TGFbeta1) gene on peritoneal mesothelial cells.

Negative_regulation (persisting) of Gene_expression (expression) of TGFbeta1 in mesothelial cells associated with renal failure and peritonitis

3) Confidence 0.36 Published 1999 Journal J. Nephrol. Section Abstract Doc Link 10626830 Disease Relevance 1.35 Pain Relevance 0.07

In conclusion: serum biochemical markers of liver fibrosis can be considered of limited value in assessing pancreatic fibrosis; in liver cirrhosis there may be a negative feed-back regulation between TGFb production and the fibrogenetic process; and in chronic pancreatitis TGFb appears to favor fibrosis on the one hand and the development of hyperglycemia on the other.

Negative_regulation (regulation) of Gene_expression (production) of TGFb in liver associated with hyperglycemia, fibrosis, cirrhosis and chronic pancreatitis

4) Confidence 0.29 Published 1998 Journal J Med Section Abstract Doc Link 10503164 Disease Relevance 1.75 Pain Relevance 0.89

Furthermore, using irradiated mice, we demonstrated that topical steroid cream significantly attenuated irradiation-induced inflammation, causing a decrease in expression of inflammatory cytokines and TGF-beta 1.

Negative_regulation (decrease) of Gene_expression (expression) of TGF associated with inflammation and cytokine

5) Confidence 0.26 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2955039 Disease Relevance 0.72 Pain Relevance 0.22

Penetrating ocular injury preformed shortly (24 h-48 h) after an AC injection of an antigen was able to abrogate ACAID and was associated with a decreased production of TGF-?

Negative_regulation (decreased) of Gene_expression (production) of TGF associated with ocular injury

6) Confidence 0.19 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2255028 Disease Relevance 0.47 Pain Relevance 0

However, a decreased production of TGF-?

Negative_regulation (decreased) of Gene_expression (production) of TGF

7) Confidence 0.19 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2255028 Disease Relevance 0.39 Pain Relevance 0.15

As shown in Figure 3, Figure 4, and Figure 5, the production of TGF-?

Negative_regulation (shown) of Gene_expression (production) of TGF

8) Confidence 0.19 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2255028 Disease Relevance 0.54 Pain Relevance 0.13

Most interestingly, only normal acini suppressed TGFbeta1 expression and accumulation specifically in normal macrophage cultures, while CP acini lost this ability.

Negative_regulation (suppressed) of Gene_expression (expression) of TGFbeta1 in macrophage associated with chronic pancreatitis

9) Confidence 0.16 Published 2008 Journal J. Pathol. Section Abstract Doc Link 18421760 Disease Relevance 1.49 Pain Relevance 1.28

These results suggest that EGF can reduce cutaneous scars by suppressing inflammatory reactions, decreasing expression of TGF-?

Negative_regulation (decreasing) of Gene_expression (expression) of TGF associated with cicatrix and inflammation

10) Confidence 0.14 Published 2010 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2844601 Disease Relevance 0.97 Pain Relevance 0.12

Furthermore, dexamethasone reduced endogenous TGF-beta1 synthesis.

Negative_regulation (reduced) of Gene_expression (synthesis) of TGF-beta1

11) Confidence 0.06 Published 1999 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 10233182 Disease Relevance 0.19 Pain Relevance 0

In human carotid artery plaques, a greater expression of TGF-?

Negative_regulation (greater) of Gene_expression (expression) of TGF in carotid artery associated with carotid stenosis

12) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.58 Pain Relevance 0.03

In VSMCs, we have found that preincubation with L-mevalonate and GGPP markedly diminishes statin-induced Smad activation and overexpression of TRII and TGF-?

Negative_regulation (diminishes) of Gene_expression (overexpression) of TGF

13) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.94 Pain Relevance 0.03

We further determined which GTPase was responsible for the synergistic effect observed with TGF-?

Negative_regulation (effect) of Gene_expression (observed) of TGF

14) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.88 Pain Relevance 0

These results indicate that a farnesylated protein can partially inhibit Statin/TGF-?

Negative_regulation (inhibit) of Gene_expression (/) of TGF

15) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.77 Pain Relevance 0

It is likely that the decreased levels of TGF-?

Negative_regulation (decreased) of Gene_expression (levels) of TGF

16) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.46 Pain Relevance 1.37

These data suggest that the augmented production of reactive oxygen species by TGF-beta1 through suppression of antioxidative enzymes may cause cellular damage and consequent apoptosis and induce pancreatitis or diabetes.

Negative_regulation (suppression) of Gene_expression (production) of TGF-beta1 associated with diabetes mellitus, pancreatitis and apoptosis

17) Confidence 0.03 Published 1997 Journal Free Radic. Biol. Med. Section Abstract Doc Link 9034240 Disease Relevance 0.43 Pain Relevance 0.06

The aim of this study was to evaluate the circulating levels of IL-6, MCP-1, TGF-beta1, IGF-1 and IGFBP-3 in patients with alcoholic chronic pancreatitis (CP).

Negative_regulation (evaluate) of Gene_expression (levels) of TGF-beta1 associated with chronic pancreatitis

18) Confidence 0.00 Published 2004 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 15074399 Disease Relevance 0.74 Pain Relevance 0.35

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