INT68035

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Context Info
Confidence 0.59
First Reported 1997
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 2.58
Pain Relevance 7.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
plasma 2
SH-SY5Y 2
nucleus 2
Pkc (Apis mellifera)
Pain Term Frequency Confidence Heat
Kinase C 90 100.00 Very High Very High Very High
substance P 1 100.00 Very High Very High Very High
Morphine 2 99.98 Very High Very High Very High
Enkephalin 5 99.74 Very High Very High Very High
MU agonist 4 99.72 Very High Very High Very High
opioid receptor 14 99.58 Very High Very High Very High
Opioid 10 99.24 Very High Very High Very High
agonist 13 99.22 Very High Very High Very High
bradykinin 2 99.06 Very High Very High Very High
adenocard 2 98.82 Very High Very High Very High
Disease Term Frequency Confidence Heat
Neuroblastoma 4 100.00 Very High Very High Very High
Cv Unclassified Under Development 8 98.12 Very High Very High Very High
Myocardial Infarction 2 93.80 High High
Necrosis 2 85.96 High High
Drug Induced Neurotoxicity 6 80.64 Quite High
INFLAMMATION 1 78.04 Quite High
Pain 1 77.48 Quite High
Coronary Heart Disease 1 75.00 Quite High
Stress 2 73.52 Quite High
Coronary Vasospasm 4 61.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MDMA-mediated PKC translocation also requires the presence of extracellular calcium ions.
Positive_regulation (requires) of Localization (translocation) of PKC associated with kinase c
1) Confidence 0.59 Published 1998 Journal Neuropsychopharmacology Section Abstract Doc Link 9718590 Disease Relevance 0.15 Pain Relevance 0.89
MDMA-mediated PKC translocation also requires the presence of extracellular calcium ions.
Positive_regulation (MDMA-mediated) of Localization (translocation) of PKC associated with kinase c
2) Confidence 0.43 Published 1998 Journal Neuropsychopharmacology Section Abstract Doc Link 9718590 Disease Relevance 0.15 Pain Relevance 0.89
In contrast, full agonists to 5-HT1A and 5-HT2 receptors did not produce significant PKC translocation.
Neg (not) Positive_regulation (produce) of Localization (translocation) of PKC associated with kinase c and agonist
3) Confidence 0.43 Published 1998 Journal Neuropsychopharmacology Section Abstract Doc Link 9718590 Disease Relevance 0.15 Pain Relevance 0.89
Exposure for 2-6 h to [D-Ala2,N-Me-Phe4,Gly-ol]enkephalin or morphine promotes the translocation of PKC from the cytosol to the plasma membrane.
Positive_regulation (promotes) of Localization (translocation) of PKC in plasma associated with kinase c, enkephalin and morphine
4) Confidence 0.42 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 9930730 Disease Relevance 0.15 Pain Relevance 1.68
PKC translocation to the membrane of SH-SY5Y neuroblastoma cells is induced by mu-opioid agonists.
Positive_regulation (induced) of Localization (translocation) of PKC in SH-SY5Y associated with neuroblastoma, mu agonist and kinase c
5) Confidence 0.42 Published 1999 Journal J. Neurochem. Section Title Doc Link 9930730 Disease Relevance 0.18 Pain Relevance 1.18
In these cells, KCl induced the translocation of PKC-alpha into the nucleus, increasing nuclear PKC activity.
Positive_regulation (induced) of Localization (translocation) of PKC in nucleus associated with kinase c
6) Confidence 0.20 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9045701 Disease Relevance 0.07 Pain Relevance 0.47
In the rabbit, the brief period of preconditioning ischemia and reperfusion releases adenosine, bradykinin, opioids, and oxygen radicals that summate to induce the translocation and activation of protein kinase C (PKC).
Positive_regulation (induce) of Localization (translocation) of PKC associated with kinase c, adenocard, ischemia, opioid and bradykinin
7) Confidence 0.09 Published 1999 Journal J. Cardiovasc. Electrophysiol. Section Abstract Doc Link 10355930 Disease Relevance 0.61 Pain Relevance 0.57
In the rabbit, the brief period of preconditioning ischemia and reperfusion releases adenosine, bradykinin, opioids, and oxygen radicals that summate to induce the translocation and activation of protein kinase C (PKC).
Positive_regulation (activation) of Localization (translocation) of PKC associated with kinase c, adenocard, ischemia, opioid and bradykinin
8) Confidence 0.09 Published 1999 Journal J. Cardiovasc. Electrophysiol. Section Abstract Doc Link 10355930 Disease Relevance 0.61 Pain Relevance 0.57
PGF2alpha caused Ca2+-dependent alpha-PKC and Ca2+-independent epsilon-PKC translocation from cytosolic to particulate fractions that was inhibited by calphostin C.
Positive_regulation (caused) of Localization (translocation) of PKC
9) Confidence 0.04 Published 2003 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 14600078 Disease Relevance 0.17 Pain Relevance 0.19
PGF2alpha caused Ca2+-dependent alpha-PKC and Ca2+-independent epsilon-PKC translocation from cytosolic to particulate fractions that was inhibited by calphostin C.
Positive_regulation (caused) of Localization (translocation) of PKC
10) Confidence 0.04 Published 2003 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 14600078 Disease Relevance 0.17 Pain Relevance 0.19
Upon stimulation of the NK1 receptor with Substance P, the activated PKC relocated to lipid rafts.
Positive_regulation (stimulation) of Localization (relocated) of PKC associated with kinase c and substance p
11) Confidence 0.02 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15590676 Disease Relevance 0.16 Pain Relevance 0.35

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