INT68245

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Context Info
Confidence 0.38
First Reported 1997
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.78
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
CII 2
IgG2a (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 90 99.48 Very High Very High Very High
Enkephalin 7 98.00 Very High Very High Very High
cINOD 5 97.68 Very High Very High Very High
dexamethasone 5 94.80 High High
methotrexate 5 94.40 High High
Inflammation 35 86.64 High High
rheumatoid arthritis 76 84.24 Quite High
cytokine 25 72.92 Quite High
agonist 8 72.16 Quite High
transdermal 7 50.00 Quite Low
Disease Link Frequency Relevance Heat
Arthritis 90 99.48 Very High Very High Very High
INFLAMMATION 48 92.92 High High
Immunization 60 88.44 High High
Rheumatoid Arthritis 78 84.24 Quite High
Influenza Virus Infection 35 82.96 Quite High
Pressure And Volume Under Development 8 75.52 Quite High
Autoimmune Disease 18 58.04 Quite High
Graft Vs Host Disease 3 34.08 Quite Low
Infection 5 31.04 Quite Low
Disease 36 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Administration of indomethacin resulted in suppression of antigen (OVA)-induced arthritis that was associated with inhibition of anti-OVA IgG2a but not IgG1 production.
Negative_regulation (inhibition) of Gene_expression (production) of IgG2a associated with arthritis
1) Confidence 0.38 Published 2003 Journal J Pharm Sci Section Abstract Doc Link 12884258 Disease Relevance 0.33 Pain Relevance 0.38
Administrations of all the drugs used resulted in suppression of antigen (OVA)-induced arthritis in mice which was associated with inhibition of anti-OVA IgG2a but not IgG1 production.
Negative_regulation (inhibition) of Gene_expression (production) of IgG2a associated with arthritis
2) Confidence 0.36 Published 2005 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 15698518 Disease Relevance 0.62 Pain Relevance 0.57
Results show that proliferation was not affected by either peptide, but that IgM, IgG3 and IgG2a production were inhibited in a concentration- and time-dependent manner by MENK.
Negative_regulation (inhibited) of Gene_expression (production) of IgG2a associated with enkephalin
3) Confidence 0.25 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9058757 Disease Relevance 0 Pain Relevance 0.45
production after IM vaccination is consistent with the heightened Th1-like response indicated by the reduced IgG1/IgG2a ratio in the IM groups, since IFN-?
Negative_regulation (reduced) of Gene_expression (ratio) of IgG2a
4) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651574 Disease Relevance 0.16 Pain Relevance 0
Furthermore, B7-H4Ig plasmid treatment suppressed the production of total IgG (Figure 5C) and IgG1, IgG2a, and IgG2b autoantibodies to CII (Figure S7).
Negative_regulation (suppressed) of Gene_expression (production) of IgG2a in CII
5) Confidence 0.17 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 0.68 Pain Relevance 0.30
In addition, one mouse exhibited high IgG2a production after twelve weeks.
Negative_regulation (exhibited) of Gene_expression (production) of IgG2a
6) Confidence 0.10 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1459156 Disease Relevance 0 Pain Relevance 0.04

General Comments

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