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Context Info
Confidence 0.78
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 34
Total Number 38
Disease Relevance 16.04
Pain Relevance 4.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (BGLAP) extracellular region (BGLAP) cell adhesion (BGLAP)
Golgi apparatus (BGLAP) structural molecule activity (BGLAP) cytoplasm (BGLAP)
Anatomy Link Frequency
osteoblasts 4
MG-63 2
Joint 1
liver 1
urine 1
BGLAP (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 33 100.00 Very High Very High Very High
MU agonist 9 99.92 Very High Very High Very High
opioid receptor 10 98.30 Very High Very High Very High
Inflammation 109 98.04 Very High Very High Very High
Arthritis 266 97.52 Very High Very High Very High
cytokine 79 94.20 High High
Morphine 8 91.76 High High
Enkephalin 5 90.72 High High
Osteoarthritis 197 90.60 High High
headache 6 88.60 High High
Disease Link Frequency Relevance Heat
Cancer 157 99.88 Very High Very High Very High
Obesity 21 99.30 Very High Very High Very High
Respiratory Syncytial Virus 464 98.94 Very High Very High Very High
Hypercalcemia 143 98.80 Very High Very High Very High
Osteoporotic Fractures 9 98.44 Very High Very High Very High
Influenza In Birds 42 98.40 Very High Very High Very High
Metastasis 47 98.36 Very High Very High Very High
Osteoporosis 217 98.26 Very High Very High Very High
Arthritis 36 98.04 Very High Very High Very High
Growth Problems 4 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of zinc supplementation on growth hormone secretion, IGF-I, IGFBP-3, somatomedin generation, alkaline phosphatase, osteocalcin and growth in prepubertal children with idiopathic short stature.
Localization (secretion) of osteocalcin associated with growth problems
1) Confidence 0.78 Published 2005 Journal J. Pediatr. Endocrinol. Metab. Section Title Doc Link 15679071 Disease Relevance 0.23 Pain Relevance 0.07
In previous studies, opioid receptors were detected in human osteoblasts, and the effects of different opioid agonists on osteocalcin secretion were tested.
Localization (secretion) of osteocalcin in osteoblasts associated with mu agonist and opioid receptor
2) Confidence 0.76 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1891106 Disease Relevance 0.68 Pain Relevance 0.85
Optimal osteogenic differentiation in both cell types, as determined by alkaline phosphatase cytochemistry, secretion of osteocalcin, mineral (calcium phosphate) deposition and scanning electron microscopy, was obtained with the same three-dimensional culture.
Localization (secretion) of osteocalcin
3) Confidence 0.74 Published 2004 Journal Cells Tissues Organs (Print) Section Abstract Doc Link 15550755 Disease Relevance 0.33 Pain Relevance 0.08
We have therefore thought it of interest to study the presence of opioid receptors in the human osteoblast-like cell line MG-63, and to evaluate the effects of different opioid agonists on the secretion of alkaline phosphatase and osteocalcin by these cells.
Localization (secretion) of osteocalcin in MG-63 associated with mu agonist, osteoporosis and opioid receptor
4) Confidence 0.71 Published 2000 Journal Neuroendocrinology Section Abstract Doc Link 11025413 Disease Relevance 0.62 Pain Relevance 0.79
Expression of opioid receptors in osteoblast-like MG-63 cells, and effects of different opioid agonists on alkaline phosphatase and osteocalcin secretion by these cells.
Localization (secretion) of osteocalcin in MG-63 associated with mu agonist, osteoporosis and opioid receptor
5) Confidence 0.71 Published 2000 Journal Neuroendocrinology Section Title Doc Link 11025413 Disease Relevance 0.62 Pain Relevance 0.47
Oral clearance of OC was found to be ?
Localization (clearance) of OC
6) Confidence 0.51 Published 2010 Journal Journal of Antimicrobial Chemotherapy Section Body Doc Link PMC2835511 Disease Relevance 0.06 Pain Relevance 0
300 ng/ml with 75 and 150 mg bid, respectively; the corresponding mean AUC0–12 values are 2270 and 4900 ng.h/ml.[9], [10], [11], [12] OC is filtered and secreted into the urine via the human organic anion transporter 1; doses should be halved in patients with a creatinine clearance (CCRCl) of <30 ml/minute.
Localization (secreted) of OC in urine associated with disorders of creatine metabolism
7) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565445 Disease Relevance 0.98 Pain Relevance 0.09
To ensure that all participants had the knowledge base required, plenary talks provided an overview of the current understanding of the processes and hazards associated with OC release to the environment.
Localization (release) of OC
8) Confidence 0.47 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2592279 Disease Relevance 0.15 Pain Relevance 0
Although questions of safety assurance depend on professional judgment, the consensus of this workshop was that OE-P and OC release into the environment might still pose risks associated with the generation of antiviral resistance or destabilization of microbial biofilms that are key to the performance and function of STPs.
Localization (release) of OC
9) Confidence 0.47 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2592279 Disease Relevance 0.19 Pain Relevance 0.13
It has been suggested that the release of OC into rivers generates OC resistance in avian influenza in wildfowl (Singer et al. 2007).
Localization (release) of OC associated with influenza in birds
10) Confidence 0.47 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2592279 Disease Relevance 0.28 Pain Relevance 0
8 weeks of OC release into receiving rivers during a pandemic (Singer et al. 2007).
Localization (release) of OC
11) Confidence 0.47 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2592279 Disease Relevance 0.16 Pain Relevance 0
The effect of these drugs or of the addition of LTB(4) on alkaline phosphatase (AP) activity and osteocalcin release by OA and normal osteoblasts was determined.
Localization (release) of osteocalcin in osteoblasts
12) Confidence 0.45 Published 2002 Journal Arthritis Rheum. Section Body Doc Link 12124864 Disease Relevance 0.08 Pain Relevance 0
Licofelone dose-dependently stimulated 1,25-dihydroxyvitamin D-induced AP activity while inhibiting osteocalcin release.
Localization (release) of osteocalcin
13) Confidence 0.45 Published 2002 Journal Arthritis Rheum. Section Body Doc Link 12124864 Disease Relevance 0.05 Pain Relevance 0
Exposure to OC is increased as a result of decreased renal function, and severe renal insufficiency (creatinine clearance rates of <30 mL/min) is associated with a marked increase in exposure.4,17 In this patient group, a reduced treatment dose of 75 mg once daily is recommended.3 Oseltamivir is not recommended for patients with end-stage renal disease (creatinine clearance <10 mL/min).3 In vitro experiments indicate that the metabolic pathway of oseltamivir conversion into OC in the liver is unlikely to be appreciably altered in subjects with moderate hepatic impairment.18 This has been confirmed in a clinical study, and no dose adjustment is recommended for patients with mild to moderate hepatic impairment.11

Influence of age

Localization (Exposure) of OC in liver associated with disorders of creatine metabolism, renal disease and renal insufficiency
14) Confidence 0.44 Published 2010 Journal Journal of Antimicrobial Chemotherapy Section Body Doc Link PMC2835511 Disease Relevance 0.37 Pain Relevance 0
Oseltamivir and OC haemofilter ‘excretions’ were 1.4 and 25 mg over 12 hours for haemofilter clearances of 25.19 and 41.46 ml/min, respectively.


Localization (excretions) of OC
15) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565445 Disease Relevance 0.09 Pain Relevance 0
There is concern regarding this use pattern and whether sufficient OC is released into rivers within Japan to generate an OC-resistant strain even before the onset of a pandemic.
Localization (released) of OC associated with sprains and strains
16) Confidence 0.41 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2592279 Disease Relevance 0.46 Pain Relevance 0
-carboxylation of bone glutamic acid residues and secretion of osteocalcin, sustains the lumbar BMD and prevents osteoporotic fractures in patients with osteoporosis.8 Shiota et al.9 showed in a randomized controlled study conducted on 40 postmenopausal women with osteoporosis that 2 years of treatment with cyclical etidronate (200 mg/day for 2 weeks every 12 weeks) plus alfacalcidol (0.5 µg/day) and calcium lactate (2g/day) was more effective in increasing the lumbar BMD and preventing vertebral fractures than treatment with alfacalcidol and calcium lactate alone.
Localization (secretion) of osteocalcin associated with osteoporosis and osteoporotic fractures
17) Confidence 0.37 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2815806 Disease Relevance 0.66 Pain Relevance 0
There was a tendency for all treated specimens to show higher levels of vitamin D3-induced osteocalcin release, yet this failed to reach statistical significance (Figure 1b).


Localization (release) of osteocalcin
18) Confidence 0.27 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0.44 Pain Relevance 0.15
Our objective in this study was to determine the likely concentrations of OC released into U.S. and U.K. river catchments using hydrologic modeling and current assumptions about the course and management of an influenza pandemic.


Localization (released) of OC associated with influenza virus infection
19) Confidence 0.26 Published 2007 Journal Environ Health Perspect Section Abstract Doc Link PMC1797841 Disease Relevance 0.60 Pain Relevance 0
Attention should be given to developing methods to minimize the release of OC into the waste stream, such as biological and chemical pretreatment in toilets, which could eliminate much of the “downstream” risk.
Localization (release) of OC
20) Confidence 0.26 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1797841 Disease Relevance 0.18 Pain Relevance 0

General Comments

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