INT68289

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Context Info
Confidence 0.45
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.34
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Accn1) plasma membrane (Accn1)
Accn1 (Mus musculus)
Pain Link Frequency Relevance Heat
ASIC 6 100.00 Very High Very High Very High
c fibre 17 99.60 Very High Very High Very High
hyperexcitability 1 93.84 High High
Pain 2 89.00 High High
Inflammation 3 87.60 High High
TRP channel 7 82.60 Quite High
nociceptor 19 81.64 Quite High
action potential duration 1 45.48 Quite Low
Calcitonin gene-related peptide 22 20.32 Low Low
Nerve growth factor 29 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 2 89.00 High High
INFLAMMATION 3 87.60 High High
Acidosis 1 86.08 High High
Nociception 2 81.80 Quite High
Ganglion Cysts 66 50.00 Quite Low
Targeted Disruption 14 49.84 Quite Low
Apoptosis 8 5.00 Very Low Very Low Very Low
Death 7 5.00 Very Low Very Low Very Low
Sprains And Strains 6 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the mechanical thresholds of C fibre units decrease and ASIC2 expression is increased at the RNA and protein levels.
Positive_regulation (increased) of Gene_expression (expression) of ASIC2 associated with c fibre
1) Confidence 0.45 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.39
Heterologous expression of ASIC induces an amiloride-sensitive cation (Na+ > Ca2+ > K+) channel which is transiently activated by rapid extracellular acidification.
Positive_regulation (induces) of Gene_expression (expression) of ASIC associated with asic
2) Confidence 0.41 Published 1997 Journal Nature Section Abstract Doc Link 9062189 Disease Relevance 0.34 Pain Relevance 0.44

General Comments

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