INT6838

Context Info Confidence 0.08 First Reported 1984 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 0.80 Pain Relevance 0.18

plasma membrane (Atp2b4)

Anatomy Link Frequency reticulum 1 Atp2b4 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Potency 1 78.96 antiarrhythmic agent 2 75.00 lidocaine 1 71.40 Angina 2 25.00 cytokine 4 5.00 Bile 3 5.00 Inflammation 2 5.00 metalloproteinase 2 5.00 Hippocampus 2 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Shock 7 99.34 Pressure And Volume Under Development 2 94.72 Coronary Vasospasm 3 93.44 Stress 9 83.04 Death 1 82.48 Ulcers 5 56.56 Vasculitis 1 52.68 Hypoxia 2 38.00 Cv Unclassified Under Development 1 37.68 Coronary Heart Disease 4 25.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Prior oral administration of glucosamine significantly prevented the ibuprofen-induced depletion of protein and glycoprotein components and maintained the activities of membrane bound ATPases as compared to untreated ulcer induced group of rats.

ATPases Binding (bound) of

1) Confidence 0.08 Published 2007 Journal J. Gastroenterol. Hepatol. Section Body Doc Link 17504261 Disease Relevance 0.06 Pain Relevance 0

As mentioned previously, Chordc1 encodes for a protein involved in forming heat shock protein complexes that can then interact with ATPases and protein phosphatases to modulate the activity of Nod1 in its role in innate immune responses [8].

ATPases Binding (interact) of associated with shock

2) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607546 Disease Relevance 0.26 Pain Relevance 0

Since free Mg++ ions are necessary for maintaining Ca+ ions (both plasma membrane-bound and sarcoplasmic reticulum membrane-bound via Ca++ ATPases), intracellular free Mg++ would rise in conditions which result in cellular loss of Mg++, thereby exacerbating and contributing to elevation of blood pressure and coronary vasospasm.

ATPases Binding (membrane-bound) of in reticulum associated with pressure and volume under development and coronary vasospasm

3) Confidence 0.01 Published 1984 Journal Drugs Section Abstract Doc Link 6149922 Disease Relevance 0.48 Pain Relevance 0.04

It seems that inhibitory effects of DHBCN derivatives on Na+,K(+)-ATPase and Mg(2+)-activated ATPase increase with an increase in lipophilicity, while hydrophilic groups of the drugs may not be important for interaction between drugs and ATPases.

ATPases Binding (interaction) of

4) Confidence 0.00 Published 1992 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 1334277 Disease Relevance 0 Pain Relevance 0.14

General Comments

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