INT68529

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Context Info
Confidence 0.14
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.79
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ADRA2B) cell-cell signaling (ADRA2B) signal transducer activity (ADRA2B)
Anatomy Link Frequency
ovary 1
ADRA2B (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 14 99.76 Very High Very High Very High
Central nervous system 1 98.76 Very High Very High Very High
Immobilon 3 92.64 High High
opioid receptor 4 88.00 High High
Delta opioid receptors 1 80.20 Quite High
Catecholamine 7 73.88 Quite High
Opioid 1 47.28 Quite Low
antagonist 17 5.00 Very Low Very Low Very Low
agonist 14 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 29 94.08 High High
Neuroblastoma 2 78.16 Quite High
Shock 34 78.00 Quite High
Sepsis 13 70.52 Quite High
Pressure Volume 2 Under Development 4 58.40 Quite High
Hemorrhagic Shock 2 46.08 Quite Low
Hypoxia 5 42.56 Quite Low
Vasoplegia 1 28.20 Quite Low
Disease 3 16.56 Low Low
Myocardial Infarction 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other receptors negatively coupled to adenylyl cyclase, namely, D2-dopaminergic, alpha 2-adrenergic, and m2/m4-muscarinic, were identified by screening of these cells, and it was shown that prolonged treatment (2 h) with 1 microM 2-bromo-alpha-ergocryptine or 1 microM arterenol resulted in a marked desensitization of D2-dopaminergic and alpha 2-adrenergic receptors, respectively.
Negative_regulation (desensitization) of alpha 2-adrenergic
1) Confidence 0.14 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9084451 Disease Relevance 0.15 Pain Relevance 0.31
The underlying mechanism of this is unknown but possibilities include coupling between G-protein-coupled receptors [36], interaction between G-proteins, and interference with G-protein-coupled receptor downregulation through arrestin trafficking.
Negative_regulation (downregulation) of G-protein-coupled receptor
2) Confidence 0.04 Published 2004 Journal Crit Care Section Body Doc Link PMC420051 Disease Relevance 0.63 Pain Relevance 0.06
G-protein-coupled receptors (GPCRsa) aAbbreviations: GPCR, G-protein-coupled receptor; AR, adenosine receptor; CNS, central nervous system; SEA, similarity ensemble approach; PDB, Protein Data Bank; WOMBAT, World of Molecular Bioactivity; CHO, Chinese hamster ovary; DMEM, Dulbecco’s modified Eagle medium; PKA, protein kinase A; DLS, dynamic light scattering. are a large family of transmembrane proteins that signal intracellularly after binding an extracellular ligand.
Negative_regulation (aAbbreviations) of G-protein-coupled receptor in ovary associated with adenocard and central nervous system
3) Confidence 0.02 Published 2010 Journal Journal of Medicinal Chemistry Section Body Doc Link PMC2865168 Disease Relevance 0 Pain Relevance 0.10

General Comments

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