INT68651

Context Info Confidence 0.58 First Reported 1997 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 11 Total Number 11 Disease Relevance 4.28 Pain Relevance 3.04

cytosol (JUN) nucleoplasm (JUN) nuclear chromosome (JUN) aging (JUN) nucleus (JUN) DNA binding (JUN)

Anatomy Link Frequency chondrocytes 2 endothelial cells 2 HL-60 2 spinal cord neurons 2 JUN (Homo sapiens)

Pain Link Frequency Relevance Heat qutenza 21 100.00 aspirin 15 99.64 Spinal cord 5 99.52 Glutamate 3 99.28 Inflammatory response 1 96.60 Osteoarthritis 36 96.28 Inflammation 15 95.00 Pain 8 77.16 Dorsal horn 1 75.00 Analgesic 4 67.76

Disease Link Frequency Relevance Heat Cancer 27 100.00 Repression 1 100.00 Skin Cancer 8 99.56 Leukemia 5 98.68 INFLAMMATION 22 96.60 Osteoarthritis 36 96.28 Infection 2 88.68 Necrosis 6 83.16 Stress 3 77.60 Pain 7 77.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

RESULTS: Sevoflurane inhibited activation of the transcription factor AP-1.

Negative_regulation (inhibited) of Positive_regulation (activation) of AP-1

1) Confidence 0.58 Published 2004 Journal Anesthesiology Section Body Doc Link 15329596 Disease Relevance 0 Pain Relevance 0

Aspirin and aspirin-like salicylates inhibited the activation of AP-1 in the same dose range as seen for the inhibition of tumor promoter-induced transformation.

Negative_regulation (inhibited) of Positive_regulation (activation) of AP-1 associated with aspirin and cancer

2) Confidence 0.48 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9092536 Disease Relevance 0.77 Pain Relevance 0.43

Overexpression of ICER in cultured spinal cord neurons results in the repression of the c-fos and c-jun promoters induced by forskolin and glutamate.

Negative_regulation (repression) of Positive_regulation (induced) of c-jun in spinal cord neurons associated with glutamate, repression and spinal cord

3) Confidence 0.42 Published 1997 Journal Eur. J. Neurosci. Section Abstract Doc Link 9517483 Disease Relevance 0.25 Pain Relevance 0.47

The results showed that (i) aspirin, fenofibrate and clofibrate decrease significantly the MCP-1 expression and secretion in human endothelial cells; (ii) the high glucose up-regulated expression of MCP-1 in endothelial cells was significantly reduced by inhibitors of NF-kB and reactive oxygen species; (iii) all drugs notably decrease the level of the reactive oxygen species and activation of NF-kB and AP-1.

Negative_regulation (decrease) of Positive_regulation (activation) of AP-1 in endothelial cells associated with aspirin

4) Confidence 0.40 Published 2006 Journal Vascul. Pharmacol. Section Abstract Doc Link 16600694 Disease Relevance 0.34 Pain Relevance 0.29

CONCLUSION: Morphine inhibits activator protein 1 activation by a mu opioid receptor pathway coupled to nitric oxide as second messenger.

Negative_regulation (inhibits) of Positive_regulation (activation) of activator protein 1

5) Confidence 0.33 Published 2007 Journal Eur J Anaesthesiol Section Body Doc Link 17583593 Disease Relevance 0 Pain Relevance 0

Treatment of melanoma cells with capsaicin inhibited activation of constitutive and IL-1beta-induced NF-kappaB, but not AP-1, leading to inhibition of IL-8 expression.

Negative_regulation (inhibited) of Positive_regulation (activation) of AP-1 associated with qutenza and skin cancer

6) Confidence 0.21 Published 2002 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 12034025 Disease Relevance 0.73 Pain Relevance 0.43

It achieved this by affecting phosphorylation of JNK and p38 MAPKs and consequently inhibiting c-jun and junD activation.

Negative_regulation (inhibiting) of Positive_regulation (activation) of c-jun

7) Confidence 0.20 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212570 Disease Relevance 0.24 Pain Relevance 0.12

Inhibitory effects of curcumin and capsaicin on phorbol ester-induced activation of eukaryotic transcription factors, NF-kappaB and AP-1.

Negative_regulation (effects) of Positive_regulation (activation) of AP-1 associated with qutenza

8) Confidence 0.09 Published 2000 Journal Biofactors Section Title Doc Link 11216470 Disease Relevance 0.36 Pain Relevance 0.34

Based on these findings, it is likely that curcumin and capsaicin exert anti-tumor promotional effects through suppression of the tumor promoter-induced activation of transcription factors, NF-kappaB and AP-1.

Negative_regulation (suppression) of Positive_regulation (activation) of AP-1 associated with qutenza and cancer

9) Confidence 0.09 Published 2000 Journal Biofactors Section Abstract Doc Link 11216470 Disease Relevance 0.65 Pain Relevance 0.31

Likewise, both compounds inhibited NF-kappaB and AP-1 activation in cultured human promyelocytic leukemia (HL-60) cells stimulated with TPA.

Negative_regulation (inhibited) of Positive_regulation (activation) of AP-1 in HL-60 associated with leukemia

10) Confidence 0.09 Published 2000 Journal Biofactors Section Abstract Doc Link 11216470 Disease Relevance 0.50 Pain Relevance 0.32

This resulted in the reduced accumulation of phosphorylated c-Jun and activation protein-1 DNA binding activity, and of activation protein-1-mediated inflammatory responses in OA chondrocytes.

Negative_regulation (reduced) of Positive_regulation (accumulation) of c-Jun in chondrocytes associated with inflammatory response and osteoarthritis

11) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888220 Disease Relevance 0.44 Pain Relevance 0.31

General Comments

This test has worked.