INT68766

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Context Info
Confidence 0.30
First Reported 1997
Last Reported 2009
Negated 3
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 4.76
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CPOX) small molecule metabolic process (CPOX) oxidoreductase activity (CPOX)
cytoplasm (CPOX)
Anatomy Link Frequency
pancreas 2
lung 2
placenta 2
CPOX (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 6 94.08 High High
Abeta 2 93.04 High High
cINOD 9 85.00 Quite High
Inflammation 17 84.40 Quite High
antagonist 28 81.92 Quite High
aspirin 13 73.12 Quite High
Pain 3 60.16 Quite High
Spinal cord 24 55.08 Quite High
COX2 9 50.00 Quite Low
cOX1 6 50.00 Quite Low
Disease Link Frequency Relevance Heat
Carcinoma 3 99.68 Very High Very High Very High
Lung Cancer 4 99.44 Very High Very High Very High
Cancer 6 99.16 Very High Very High Very High
Adenocarcinoma 4 99.16 Very High Very High Very High
Pancreatic Cancer 10 94.68 High High
Reprotox - General 1 1 94.48 High High
Alzheimer's Dementia 1 90.76 High High
Colon Cancer 1 90.68 High High
Neuroblastoma 44 90.60 High High
Necrosis 1 89.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sodium salicylate inhibited prostaglandin E2 release when added together with interleukin 1beta for 24 hr with an IC50 value of 5 microg/ml, an effect that was independent of NF-kappaB activation or COX-2 transcription or translation.
Positive_regulation (activation) of Transcription (transcription) of COX
1) Confidence 0.30 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9187256 Disease Relevance 0.34 Pain Relevance 0.36
Sodium salicylate inhibited prostaglandin E2 release when added together with interleukin 1beta for 24 hr with an IC50 value of 5 microg/ml, an effect that was independent of NF-kappaB activation or COX-2 transcription or translation.
Neg (independent) Positive_regulation (independent) of Transcription (transcription) of COX
2) Confidence 0.30 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9187256 Disease Relevance 0.34 Pain Relevance 0.37
Increased levels of COX-2 mRNA were found in four of five cell lines, and only in PANC-1 cells was the low level of transcript comparable to that in the normal pancreas.
Positive_regulation (Increased) of Transcription (levels) of COX in pancreas
3) Confidence 0.24 Published 1999 Journal Cancer Res. Section Abstract Doc Link 10485483 Disease Relevance 0.72 Pain Relevance 0.14
The effects of AA are independent from induction of COX mRNA expression, or of de novo protein synthesis.
Positive_regulation (induction) of Transcription (expression) of COX
4) Confidence 0.22 Published 2002 Journal Brain Res. Section Abstract Doc Link 12270500 Disease Relevance 0.66 Pain Relevance 0.14
In contrast, Cox-1 mRNA levels were not elevated in the carcinoma.
Neg (not) Positive_regulation (elevated) of Transcription (levels) of Cox associated with carcinoma
5) Confidence 0.18 Published 1997 Journal Cancer Res. Section Abstract Doc Link 9102213 Disease Relevance 0.94 Pain Relevance 0.23
Cyclooxygenase (COX)-2 mRNA and protein expression were found to be frequently elevated in human pancreatic adenocarcinomas and cell lines derived from such tumors.
Positive_regulation (elevated) of Transcription (expression) of COX associated with adenocarcinoma and cancer
6) Confidence 0.16 Published 1999 Journal Cancer Res. Section Abstract Doc Link 10485483 Disease Relevance 0.58 Pain Relevance 0.07
COX-2 mRNA expression was higher in RA than in OA samples (P < 0.05).
Positive_regulation (higher) of Transcription (expression) of COX
7) Confidence 0.15 Published 1998 Journal Arthritis Rheum. Section Body Doc Link 9433877 Disease Relevance 0.32 Pain Relevance 0
ATRA also up-regulated COX-2 mRNA expression and increased the activity of a human COX-2 promoter construct.
Positive_regulation (regulated) of Transcription (expression) of COX
8) Confidence 0.09 Published 2007 Journal J Neuroinflammation Section Abstract Doc Link PMC1769480 Disease Relevance 0.37 Pain Relevance 0.14
Previous studies have found contradictory results on the effect of ATRA on COX-2 expression: For instance, ATRA repressed COX-2 promoter activity and COX-2 mRNA expression in several murine lung tumour-derived cell lines, yet it increased promoter activity and COX-2 mRNA expression significantly in another lung tumour-derived cell line [27].
Positive_regulation (increased) of Transcription (expression) of COX in lung associated with lung cancer
9) Confidence 0.09 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1769480 Disease Relevance 0.20 Pain Relevance 0.04
COX-1 mRNA expression does not differ in placenta of preeclamptic pregnancies, but is elevated in the placental bed, as compared to normal pregnancies; while COX-2 mRNA was unchanged.
Neg (not) Positive_regulation (elevated) of Transcription (expression) of COX in placenta
10) Confidence 0.07 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.28 Pain Relevance 0

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