INT68865

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Context Info
Confidence 0.52
First Reported 1997
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 5.49
Pain Relevance 2.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (ACOX1) mitochondrion (ACOX1) small molecule metabolic process (ACOX1)
peroxisome (ACOX1) lipid metabolic process (ACOX1) cytoplasm (ACOX1)
Anatomy Link Frequency
skeletal muscle 1
H-4-II-E 1
ACOX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
electroacupuncture 246 99.50 Very High Very High Very High
Acupuncture 30 93.68 High High
diclofenac 1 93.44 High High
transdermal 1 92.12 High High
addiction 1 91.00 High High
Analgesic 1 89.56 High High
antagonist 4 89.32 High High
Opioid 1 88.88 High High
aspirin 24 85.84 High High
Pain 3 82.32 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 42 100.00 Very High Very High Very High
Obesity 574 99.02 Very High Very High Very High
Sprains And Strains 55 98.80 Very High Very High Very High
Insulin Resistance 94 96.48 Very High Very High Very High
Mitochondrial Disorders 11 95.68 Very High Very High Very High
Alcohol Addiction 1 91.60 High High
Diabetes Mellitus 78 91.24 High High
Opiate Addiction 1 91.00 High High
Body Weight 225 88.88 High High
Disease 69 84.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We identified prescriptions for the following sCox-2 inhibitors: newer sCox-2 inhibitors (celecoxib M01AH01, rofecoxib M01AH, valdecoxib M01AH03, etoricoxib M01AH05), and older sCox-2 inhibitors (lornoxicam M01AC05, diclofenac M01AB05, meloxicam M01AC06).
Gene_expression (prescriptions) of sCox-2 associated with diclofenac
1) Confidence 0.52 Published 2010 Journal Breast Cancer Res Section Body Doc Link PMC2879557 Disease Relevance 0.18 Pain Relevance 0.15
Straight-chain naltrexone-3-alkyl ester prodrugs of 2-7 carbons in chain length were synthesized and evaluated.
Gene_expression (synthesized) of Straight-chain naltrexone-3-alkyl
2) Confidence 0.44 Published 2002 Journal J Pharm Sci Section Abstract Doc Link 12434400 Disease Relevance 0.18 Pain Relevance 0.23
For human cell and tissue studies, identifiers were ADFP (Hs00605340_m1), adiponectin/AdipoQ (Hs00605917_m1), Cpt1b (Hs00992664_m1), PEPCK1/Pck1 (Hs00159918_m1), leptin (Hs00174877_m1), ACOX1 (Hs00244515_m1), and LPL (Hs00173425_m1).


Gene_expression (/) of ACOX1
3) Confidence 0.31 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.06 Pain Relevance 0
A promoter::chloramphenicol acetyltransferase (CAT) fusion construct for rat acyl-CoA oxidase (ACOX), the rate-limiting enzyme in the peroxisomal beta-oxidation pathway, was stably transfected into the rat liver cell line H-4-II-E.
Gene_expression (transfected) of ACOX in H-4-II-E
4) Confidence 0.30 Published 1997 Journal Cancer Res. Section Abstract Doc Link 9108462 Disease Relevance 0.13 Pain Relevance 0.28
For Western blots H. polymorpha cells of the indicated strains were cultivated on methanol-containing media to induce the expression of the AOX promoter.
Gene_expression (expression) of AOX associated with sprains and strains
5) Confidence 0.15 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2287180 Disease Relevance 0.10 Pain Relevance 0
, NRF1, and ACOX gene expression.
Gene_expression (expression) of ACOX gene
6) Confidence 0.07 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 1.00 Pain Relevance 0.63
VLCAD, PT, acyl-CoA oxidase (ACOX) A, and ACOX B proteins were significantly higher in unexposed hPPAR?
Gene_expression (proteins) of ACOX B
7) Confidence 0.06 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.18 Pain Relevance 0
The molecular mechanisms underlying the effects of fenofibrate on obesity and lipid metabolism involve the changes in the expression of apolipoprotein C-III (apo C-III) and ACOX.
Gene_expression (expression) of ACOX associated with obesity and disorder of lipid metabolism
8) Confidence 0.06 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0.77 Pain Relevance 0
Coadministration of fenofibrate and E2 significantly decreased ACOX, HD, and thiolase mRNA levels compared with fenofibrate treatment.
Gene_expression (levels) of ACOX
9) Confidence 0.06 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0.51 Pain Relevance 0
, nuclear respiratory factor 1 (NRF1), and acyl-CoA oxidase (ACOX) gene expression in the skeletal muscle of db/db mice.
Gene_expression (expression) of ACOX in skeletal muscle
10) Confidence 0.06 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.43 Pain Relevance 0.40
In db/db mice, it was observed that EA significantly increased ACOX gene expression (Figure 3(d)).


Gene_expression (expression) of ACOX gene associated with electroacupuncture
11) Confidence 0.06 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.72 Pain Relevance 0.40
VLCAD, MCAD, PH, PT, ACOX A, and ACOX B expression was slightly lower and p65 and p52 expression was slightly higher in unexposed Ppar?
Gene_expression (expression) of ACOX B
12) Confidence 0.06 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.27 Pain Relevance 0
Fenofibrate upregulated ACOX, HD, and thiolase mRNA levels whereas E2 downregulated the transcriptional activation of these genes.
Gene_expression (levels) of ACOX
13) Confidence 0.05 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0.55 Pain Relevance 0
Recent studies have shown that transgene AOX expression does not produce a detrimental phenotype in Drosophilia and was able to rescue the phenotype two different mitochondrial disease models [90].
Gene_expression (expression) of transgene AOX associated with mitochondrial disorders
14) Confidence 0.01 Published 2010 Journal Biochim Biophys Acta Section Body Doc Link PMC2795853 Disease Relevance 0.41 Pain Relevance 0

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