INT68978

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Context Info
Confidence 0.45
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 1.88
Pain Relevance 4.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Hpse) extracellular region (Hpse) cell adhesion (Hpse)
nucleus (Hpse) carbohydrate metabolic process (Hpse) lysosome (Hpse)
Anatomy Link Frequency
plasma 2
neurons 2
ventral 2
Hpse (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 28 100.00 Very High Very High Very High
tolerance 8 100.00 Very High Very High Very High
Analgesic 1 100.00 Very High Very High Very High
narcan 4 99.84 Very High Very High Very High
Inflammation 27 98.68 Very High Very High Very High
opiate 1 96.16 Very High Very High Very High
Antinociceptive 1 95.72 Very High Very High Very High
Opioid 4 94.84 High High
cytokine 23 94.72 High High
addiction 2 94.64 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 28 98.68 Very High Very High Very High
Targeted Disruption 22 98.24 Very High Very High Very High
Stress 114 97.96 Very High Very High Very High
Appetite Loss 1 93.24 High High
Fever 1 92.84 High High
Morphine Dependence 1 89.16 High High
Cognitive Disorder 1 85.32 High High
Nociception 1 74.24 Quite High
Cancer 22 5.00 Very Low Very Low Very Low
Pituitary Cancer 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined the effect of nifedipine on morphine analgesic tolerance in intact and adrenalectomized (ADX) rats and on HPA activity induced by morphine.
Spec (examined) Regulation (effect) of Positive_regulation (induced) of HPA associated with analgesic, tolerance and morphine
1) Confidence 0.45 Published 2005 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15894073 Disease Relevance 0.07 Pain Relevance 1.32
Corticotropin releasing hormone (CRH) neurons located in the hypothalamus are important for HPA activation.
Regulation (important) of Positive_regulation (activation) of HPA in neurons
2) Confidence 0.41 Published 2005 Journal Brain Res. Bull. Section Abstract Doc Link 15833600 Disease Relevance 0.19 Pain Relevance 0.30
We also evaluated the effect of this drug on HPA activity induced by naloxone.
Regulation (effect) of Positive_regulation (induced) of HPA associated with narcan
3) Confidence 0.21 Published 2008 Journal Horm Behav Section Abstract Doc Link 18177874 Disease Relevance 0.09 Pain Relevance 0.96
These findings, that the effects of morphine on HPA activation or POMC mRNA expression depend on the presence of stress, suggest a counter-regulatory role of opiates on a stress response and opioid gene expression.
Regulation (effects) of Positive_regulation (activation) of HPA associated with stress, opiate, opioid and morphine
4) Confidence 0.21 Published 1999 Journal J. Endocrinol. Section Abstract Doc Link 10556776 Disease Relevance 0.33 Pain Relevance 0.97
Importantly, the present study focussed on the adaptive changes in HPA activation which are occurring during late pregnancy.
Regulation (changes) of Positive_regulation (activation) of HPA
5) Confidence 0.13 Published 2010 Journal Brain Research Section Body Doc Link PMC2994639 Disease Relevance 0.46 Pain Relevance 0
Activation of the HPA axis in vivo depends on the secretion of CRH, an intact pituitary and the ventral adrenergic bundle innervating the hypothalamic paraventricular nucleus.
Regulation (depends) of Positive_regulation (Activation) of HPA in ventral
6) Confidence 0.12 Published 1996 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 9116324 Disease Relevance 0.40 Pain Relevance 0.11
Although IL-6 is released from the local inflammatory site (698) and circulates in plasma, local IL-6 from FS cells is involved in the activation of the HPA axis.
Regulation (involved) of Positive_regulation (activation) of HPA in plasma associated with inflammation
7) Confidence 0.02 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.34 Pain Relevance 0.36

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