INT69350

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Context Info
Confidence 0.77
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 23
Total Number 28
Disease Relevance 12.16
Pain Relevance 5.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RAC1) cell motility (RAC1) cell adhesion (RAC1)
plasma membrane (RAC1) enzyme binding (RAC1) GTPase activity (RAC1)
Anatomy Link Frequency
muscles 4
dorsal 1
colon 1
upper limb 1
bladder 1
RAC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neurotransmitter 16 100.00 Very High Very High Very High
Enkephalin 12 100.00 Very High Very High Very High
Botox 287 99.92 Very High Very High Very High
Cholecystokinin 4 99.84 Very High Very High Very High
intrathecal 1 99.80 Very High Very High Very High
palliative 1 99.08 Very High Very High Very High
dorsal rhizotomy 1 98.86 Very High Very High Very High
Potency 10 98.62 Very High Very High Very High
qutenza 13 98.60 Very High Very High Very High
Piles 3 95.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Focal Dystonia 6 99.92 Very High Very High Very High
Apoptosis 50 99.76 Very High Very High Very High
Overactive Bladder 8 99.12 Very High Very High Very High
Movement Disorders 5 98.88 Very High Very High Very High
Breast Cancer 56 98.84 Very High Very High Very High
Clostridium Infection 10 98.84 Very High Very High Very High
Spasticity 59 98.72 Very High Very High Very High
Torticollis 5 98.64 Very High Very High Very High
Injury 20 98.28 Very High Very High Very High
Stroke 65 97.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show using immunohistochemistry that Rac1 is expressed in mature colonocytes at the intercrypt table in human and mouse colon tissue.
Gene_expression (expressed) of Rac1 in colon
1) Confidence 0.77 Published 2004 Journal Carcinogenesis Section Abstract Doc Link 14976132 Disease Relevance 0.47 Pain Relevance 0.31
The small GTPase Rac1 is highly induced and this was confirmed by immunoblotting.
Gene_expression (induced) of Rac1
2) Confidence 0.67 Published 2004 Journal Carcinogenesis Section Abstract Doc Link 14976132 Disease Relevance 0.49 Pain Relevance 0.31
RESULTS: After botulinum toxin injection, the botulinum toxin group had a reduced maximum voluntary contraction for the ensuing 3 mos and smaller decreases in pressure pain threshold from before to after the sustained clench.
Gene_expression (injection) of botulinum toxin
3) Confidence 0.67 Published 2010 Journal Am J Phys Med Rehabil Section Body Doc Link 20729652 Disease Relevance 0.15 Pain Relevance 0
DESIGN: The masseter muscles were injected with botulinum toxin in 19 subjects and with isotonic saline in 16 subjects.
Gene_expression (injected) of botulinum toxin in muscles
4) Confidence 0.67 Published 2010 Journal Am J Phys Med Rehabil Section Body Doc Link 20729652 Disease Relevance 0.19 Pain Relevance 0
Botulinum toxin-A (BTX-A) was first used in its treatment in 1985.
Gene_expression (used) of Botulinum toxin
5) Confidence 0.60 Published 1999 Journal J Assoc Physicians India Section Abstract Doc Link 10999117 Disease Relevance 0.46 Pain Relevance 0.09
A therapeutic role for botulinum toxin injection into the external anal sphincter for treatment of SRUS associated with constipation and paradoxical contraction of pelvic floor and external anal sphincter muscles in children, may exist.
Gene_expression (injection) of botulinum toxin in external anal sphincter associated with stress incontinence and constipation
6) Confidence 0.55 Published 2008 Journal Eur J Gastroenterol Hepatol Section Abstract Doc Link 18188026 Disease Relevance 1.09 Pain Relevance 0.25
Module 1 has only two protein hubs, MAPK8 and the complex containing RAC1 and RAC2.
Gene_expression (containing) of RAC1
7) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0 Pain Relevance 0
The expression of Rac1N17, a dominant negative mutant of Rac1, also significantly inhibited the capsaicin-induced apoptosis.
Gene_expression (expression) of Rac1 associated with qutenza and apoptosis
8) Confidence 0.48 Published 2004 Journal Free Radic. Res. Section Abstract Doc Link 15190937 Disease Relevance 1.14 Pain Relevance 0.96
Iontophoresis still remains a useful therapy because botulinum toxin injections for the treatment of palmar and plantar hyperhidrosis are not suitable for all patients.34 Specifically, musicians, surgeons, and others who depend on fine motor dexterity in their hands may not be able to accept the risks of diminished strength of their thumbs that may accompany botulinum toxin injections.
Gene_expression (injections) of botulinum toxin in thumbs associated with skin appendage disease
9) Confidence 0.42 Published 2008 Journal Eplasty Section Body Doc Link PMC2344132 Disease Relevance 0.30 Pain Relevance 0.63
The cosmetic denervation of muscles of facial expression using botulinum toxin has given dermatologists and plastic surgeons a new weapon against facial expression-induced wrinkles and lines.
Gene_expression (expression) of botulinum toxin in muscles associated with wrinkles
10) Confidence 0.42 Published 2008 Journal Eplasty Section Body Doc Link PMC2344132 Disease Relevance 1.30 Pain Relevance 0
[The effect of botulinum toxin injection into the bladder for overactive bladder: two case].
Gene_expression (injection) of botulinum toxin in bladder associated with overactive bladder
11) Confidence 0.40 Published 2005 Journal Nippon Hinyokika Gakkai Zasshi Section Title Doc Link 15948413 Disease Relevance 0.73 Pain Relevance 0.32
Randomised controlled trials of botulinum toxin in the treatment of upper limb spasticity following stroke
Gene_expression (trials) of botulinum toxin in upper limb associated with spasticity and stroke
12) Confidence 0.37 Published 2008 Journal Trials Section Body Doc Link PMC2611962 Disease Relevance 1.27 Pain Relevance 0.20
The potency units of Dysport are not interchangeable with other preparations of botulinum toxin products and, therefore, units of biological activity of Dysport cannot be compared to or converted into units of any other botulinum toxin products.31
Gene_expression (products) of botulinum toxin associated with potency
13) Confidence 0.27 Published 2010 Journal Patient Prefer Adherence Section Body Doc Link PMC2943226 Disease Relevance 0 Pain Relevance 0.22
This was reflected in the self-perception of age data, which showed that botulinum toxin resulted in more patients considering themselves to look younger than their current age and fewer patients considering themselves to look older than their current age.
Gene_expression (resulted) of botulinum toxin
14) Confidence 0.27 Published 2010 Journal Patient Prefer Adherence Section Body Doc Link PMC2943226 Disease Relevance 0 Pain Relevance 0.12
Cosmetic uses of botulinum toxin
Gene_expression (uses) of botulinum toxin
15) Confidence 0.27 Published 2010 Journal Patient Prefer Adherence Section Body Doc Link PMC2943226 Disease Relevance 0 Pain Relevance 0.21
The potency units of Dysport are not interchangeable with other preparations of botulinum toxin products and, therefore, units of biological activity of Dysport cannot be compared to or converted into units of any other botulinum toxin products.31
Gene_expression (products.31) of botulinum toxin associated with potency
16) Confidence 0.27 Published 2010 Journal Patient Prefer Adherence Section Body Doc Link PMC2943226 Disease Relevance 0 Pain Relevance 0.20
Rac1 expression results in the induction of the IL-6 and IL-6 receptor genes and neutralizing antibodies directed against the IL-6 receptor block Rac1-induced STAT3 activation.
Gene_expression (expression) of Rac1
17) Confidence 0.26 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.07 Pain Relevance 0.04
A fourth man-made form is produced from aerosolized botulinum toxin and results in inhalational botulism.
Gene_expression (produced) of botulinum toxin associated with clostridium infection
18) Confidence 0.24 Published 2005 Journal Eur J Emerg Med Section Abstract Doc Link 16175064 Disease Relevance 1.08 Pain Relevance 0.12
Safety of botulinum toxin
Gene_expression (Safety) of botulinum toxin
19) Confidence 0.24 Published 2010 Journal Patient Prefer Adherence Section Body Doc Link PMC2943226 Disease Relevance 0.17 Pain Relevance 0.07
decreased levels of active Rac1 and its related G protein Cdc42.
Gene_expression (levels) of Rac1
20) Confidence 0.23 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.63 Pain Relevance 0.04

General Comments

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