INT69394

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Context Info
Confidence 0.49
First Reported 1997
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 9
Disease Relevance 3.54
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FOS) aging (FOS) nucleolus (FOS)
nucleus (FOS)
Anatomy Link Frequency
glial cells 2
dorsal horn 2
FOS (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 1 100.00 Very High Very High Very High
Dorsal horn 1 100.00 Very High Very High Very High
Sciatic nerve 1 99.68 Very High Very High Very High
allodynia 4 96.00 Very High Very High Very High
cINOD 3 84.40 Quite High
Lasting pain 5 83.84 Quite High
cytokine 63 82.48 Quite High
Inflammation 144 69.44 Quite High
Neurotransmitter 1 55.80 Quite High
Opioid 1 54.04 Quite High
Disease Link Frequency Relevance Heat
Injury 139 99.28 Very High Very High Very High
Cancer 21 98.48 Very High Very High Very High
Stress 340 96.88 Very High Very High Very High
Neuropathic Pain 4 96.00 Very High Very High Very High
Cirrhosis 135 85.20 High High
Pain 5 83.84 Quite High
Fever 3 81.48 Quite High
Neurodegenerative Disease 4 72.96 Quite High
INFLAMMATION 174 69.44 Quite High
Disease 58 68.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The tax1 induced c-Fos protein levels and the concurrently increased association of c-Fos/c-Jun transcription factors at the AP-1 site imply a strong functional significance in the activation of proenkephalin gene expression in tax1 expressing glial cells.
Positive_regulation (increased) of c-Fos Binding (association) of in glial cells
1) Confidence 0.49 Published 1997 Journal J. Neurovirol. Section Abstract Doc Link 9147818 Disease Relevance 0 Pain Relevance 0.14
Expression of three of the immediate early genes examined, c-fos, NGFI-A and jun B, was transiently increased in the ipsilateral dorsal horn of the spinal cord following the partial ligation of the sciatic nerve.
Spec (partial) Positive_regulation (increased) of c-fos Spec (partial) Binding (ligation) of in dorsal horn associated with dorsal horn, sciatic nerve and spinal cord
2) Confidence 0.49 Published 1997 Journal Acta Physiol. Scand. Section Abstract Doc Link 9429660 Disease Relevance 0.46 Pain Relevance 0.56
These results demonstrate a relationship between increases in AP-1 DNA-binding activity and increased cellular resistance to cancer therapeutic agents and oxidative stress that is inhibited by indomethacin.
Positive_regulation (increases) of AP-1 Binding (binding) of associated with stress and cancer
3) Confidence 0.23 Published 2001 Journal Cancer Res. Section Abstract Doc Link 11309312 Disease Relevance 0.58 Pain Relevance 0.08
These results demonstrate a relationship between increases in AP-1 DNA-binding activity and increased cellular resistance to cancer therapeutic agents and oxidative stress that is inhibited by indomethacin.
Positive_regulation (increases) of AP-1 Binding (activity) of associated with stress and cancer
4) Confidence 0.23 Published 2001 Journal Cancer Res. Section Abstract Doc Link 11309312 Disease Relevance 0.58 Pain Relevance 0.08
Treatment of OC-14 cells with indomethacin inhibited constitutive increases in AP-1 DNA-binding activity and c-Fos/c-Jun-immunoreactive protein levels.
Positive_regulation (increases) of AP-1 Binding (activity) of
5) Confidence 0.23 Published 2001 Journal Cancer Res. Section Abstract Doc Link 11309312 Disease Relevance 0.65 Pain Relevance 0.05
OxLDL caused an increase in the DNA binding activity of activator protein-1 and nuclear factor ?
Positive_regulation (increase) of activator protein-1 Binding (activity) of
6) Confidence 0.09 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2386118 Disease Relevance 0.36 Pain Relevance 0
With regard to the pro-fibrogenic mechanism, HNE has been shown in human HSC/MFs to elicit transient activation of JNK isoforms and their nuclear translocation as well as to lead to up-regulation of c-Jun and increased AP-1 binding to DNA [288]; a very similar JNK/AP-1-dependent pattern, inducing up-regulation of collagen type I, has been shown to operate in rat HSC/MFs exposed to UV irradiation [309].
Positive_regulation (increased) of AP-1 Binding (binding) of
7) Confidence 0.06 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.39 Pain Relevance 0.03
In 2003, Bataller and coworkers [318] were the first to identify the presence of components of NOX in HSC/MFs, suggesting that the pro-fibrogenic action of Ang II, as already delineated in in vivo and in vitro studies [319,320], is dependent on the associated activation of NOX and the related ROS-dependent activation of MAPKs, phosphorylation of c-Akt and increased AP-1 DNA binding activity [318], events blocked by the specific NOX inhibitor DPI (diphenyl-phenyleneiodonium) or the inhibitor of Ang II type 1 receptor (AT1), losartan.
Positive_regulation (increased) of AP-1 Binding (activity) of
8) Confidence 0.06 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.26 Pain Relevance 0.08
In 2003, Bataller and coworkers [318] were the first to identify the presence of components of NOX in HSC/MFs, suggesting that the pro-fibrogenic action of Ang II, as already delineated in in vivo and in vitro studies [319,320], is dependent on the associated activation of NOX and the related ROS-dependent activation of MAPKs, phosphorylation of c-Akt and increased AP-1 DNA binding activity [318], events blocked by the specific NOX inhibitor DPI (diphenyl-phenyleneiodonium) or the inhibitor of Ang II type 1 receptor (AT1), losartan.
Positive_regulation (increased) of AP-1 Binding (binding) of
9) Confidence 0.06 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.26 Pain Relevance 0.08

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