INT69436

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Context Info
Confidence 0.38
First Reported 1997
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 81
Total Number 85
Disease Relevance 46.58
Pain Relevance 12.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ROS1) cell proliferation (ROS1) plasma membrane (ROS1)
Anatomy Link Frequency
neutrophils 18
leukocytes 6
monocytes 5
hippocampus 3
spermatozoa 3
ROS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 38 100.00 Very High Very High Very High
cytokine 332 99.96 Very High Very High Very High
qutenza 69 99.92 Very High Very High Very High
Inflammation 599 99.76 Very High Very High Very High
Spinal cord 42 99.68 Very High Very High Very High
ischemia 60 99.60 Very High Very High Very High
Inflammatory response 71 99.58 Very High Very High Very High
Serotonin 7 99.28 Very High Very High Very High
Dorsal horn 8 99.20 Very High Very High Very High
agonist 80 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 1022 100.00 Very High Very High Very High
Injury 173 99.98 Very High Very High Very High
Hyperglycemia 84 99.78 Very High Very High Very High
INFLAMMATION 665 99.76 Very High Very High Very High
Shock 11 99.76 Very High Very High Very High
Increased Venous Pressure Under Development 173 99.68 Very High Very High Very High
Stress 1725 99.60 Very High Very High Very High
Cv Unclassified Under Development 60 99.60 Very High Very High Very High
Lung Cancer 31 99.50 Very High Very High Very High
Targeted Disruption 63 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Lidocaine and mepivacaine at higher levels significantly decreased the production of ROS by neutrophils.
Negative_regulation (decreased) of Gene_expression (production) of ROS in neutrophils
1) Confidence 0.38 Published 1997 Journal Acta Anaesthesiol Scand Section Body Doc Link 9150783 Disease Relevance 0 Pain Relevance 0
CONCLUSION: In conclusion, in the present in vitro system, only concentrations of lidocaine and mepivacaine 100-fold higher than clinically feasible ones reduced ROS production by human neutrophils.
Negative_regulation (reduced) of Gene_expression (production) of ROS in neutrophils
2) Confidence 0.38 Published 1997 Journal Acta Anaesthesiol Scand Section Body Doc Link 9150783 Disease Relevance 0 Pain Relevance 0
Bupivacaine did not decrease ROS generation by either generating system.
Neg (not) Negative_regulation (decrease) of Gene_expression (generation) of ROS
3) Confidence 0.38 Published 1997 Journal Acta Anaesthesiol Scand Section Body Doc Link 9150783 Disease Relevance 0 Pain Relevance 0
Reduction of the basal generation of ROS may play a role in the induction of apoptosis by capsaicin.
Negative_regulation (Reduction) of Gene_expression (generation) of ROS associated with qutenza and apoptosis
4) Confidence 0.38 Published 2000 Journal Cancer Lett. Section Abstract Doc Link 11078921 Disease Relevance 0.83 Pain Relevance 0.79
Treatment with N-acetyl cysteine alone induced both reduction of the basal production of ROS and apoptosis.
Negative_regulation (reduction) of Gene_expression (production) of ROS associated with apoptosis
5) Confidence 0.38 Published 2000 Journal Cancer Lett. Section Abstract Doc Link 11078921 Disease Relevance 0.76 Pain Relevance 0.81
However, the quenching of ROS generation in response to treatment with a ROS scavenger, N-acetyl-L-cysteine, reversed the platycodon D-induced apoptosis effects via inhibition of Egr-1 activation, ROS production, MMP collapse, and the subsequent activation of caspase-3.
Negative_regulation (inhibition) of Gene_expression (production) of ROS associated with shock and apoptosis
6) Confidence 0.37 Published 2009 Journal Biomed. Pharmacother. Section Abstract Doc Link 18804340 Disease Relevance 0.83 Pain Relevance 0.13
The capsaicin-induced generation of ROS and apoptosis was significantly suppressed by treatment with antioxidants, DPPD and tocopherol.
Negative_regulation (suppressed) of Gene_expression (generation) of ROS associated with qutenza and apoptosis
7) Confidence 0.36 Published 2004 Journal Free Radic. Res. Section Abstract Doc Link 15190937 Disease Relevance 1.18 Pain Relevance 0.83
In conclusion, Lido suppressed granulocyte adhesion to the endothelium and antiseptic capability by suppressing CD11b expression and/or ROS production.
Negative_regulation (suppressing) of Gene_expression (production) of ROS in granulocyte associated with adhesions
8) Confidence 0.35 Published 2010 Journal J. Vet. Med. Sci. Section Abstract Doc Link 19940395 Disease Relevance 0.10 Pain Relevance 0.17
In the hippocampus, astrocytes in the CA1 region under ischemia, display selective loss of glutamate transport activity, increased mitochondrial ROS generation, and reduced mitochondrial membrane potential.
Negative_regulation (loss) of Gene_expression (generation) of ROS in hippocampus associated with glutamate, ischemia and hippocampus
9) Confidence 0.34 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.78 Pain Relevance 0.39
The production of oxygen species (ROS) was inhibited by KTBE in FLS cells.
Negative_regulation (inhibited) of Gene_expression (production) of ROS
10) Confidence 0.33 Published 2008 Journal Arch. Pharm. Res. Section Abstract Doc Link 19023550 Disease Relevance 0.24 Pain Relevance 0.27
It may lead to decrease resistance against ROS produced in the mitochondria and to oxidative damage of proteins[30].
Negative_regulation (decrease) of Gene_expression (produced) of ROS
11) Confidence 0.32 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2386118 Disease Relevance 0.42 Pain Relevance 0
OS can be overcome by reducing generation of ROS or increasing the amounts of antioxidants available.
Negative_regulation (reducing) of Gene_expression (generation) of ROS associated with stress
12) Confidence 0.32 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.73 Pain Relevance 0.07
The antioxidant enzymes neutralize ROS production and protect the oocyte and embryo.
Negative_regulation (neutralize) of Gene_expression (production) of ROS in embryo
13) Confidence 0.32 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.26 Pain Relevance 0
Cells have developed a wide range of antioxidants systems to limit production of ROS, inactivate them and repair cell damage [1-3,33].
Negative_regulation (limit) of Gene_expression (production) of ROS
14) Confidence 0.32 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.53 Pain Relevance 0.03
Stimulation of the cyclooxygenase enzyme is brought about by ROS via activation of the transcription factor NFKappa ?
Negative_regulation (about) of Gene_expression (brought) of ROS
15) Confidence 0.31 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.59 Pain Relevance 0.16
Under normal conditions, scavenging molecules known as antioxidants convert ROS to H2O to prevent overproduction of ROS.
Negative_regulation (prevent) of Gene_expression (overproduction) of ROS
16) Confidence 0.31 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0 Pain Relevance 0.11
Under normal conditions, scavenging molecules known as antioxidants convert ROS to H2O to prevent overproduction of ROS.
Negative_regulation (prevent) of Gene_expression (overproduction) of ROS
17) Confidence 0.31 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0 Pain Relevance 0.11
Ferritin, transferrin, ceruloplasmin, metallothionein and lactoferrin can thus be seen not only as relevant for their respective role in metal homeostasis but also as molecules that, by 'sequestering' redox active metal ions, may prevent ROS production via the Fenton reaction.


Negative_regulation (prevent) of Gene_expression (production) of ROS
18) Confidence 0.31 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0 Pain Relevance 0
These findings indicate that the inhibitory effects of evodiamine and rutaecarpine on LIGHT-induced migration and the activation of CCR1, CCR2, ICAM-1, ERK, and p38 MAPK occurs via decreased ROS production and NADPH oxidase activation.
Negative_regulation (decreased) of Gene_expression (production) of ROS
19) Confidence 0.30 Published 2009 Journal J. Cell. Biochem. Section Abstract Doc Link 19241441 Disease Relevance 0.25 Pain Relevance 0.17
This redox drive to capacitation involves a low, steady state level of ROS production.
Negative_regulation (level) of Gene_expression (production) of ROS
20) Confidence 0.29 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1315356 Disease Relevance 0.22 Pain Relevance 0

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