INT6947

Context Info Confidence 0.59 First Reported 1980 Last Reported 2010 Negated 3 Speculated 1 Reported most in Abstract Documents 37 Total Number 38 Disease Relevance 10.32 Pain Relevance 14.14

small molecule metabolic process (POMC) cell-cell signaling (POMC) cytoplasm (POMC) extracellular space (POMC) generation of precursor metabolites and energy (POMC) signal transduction (POMC)

Anatomy Link Frequency plasma 16 GH 3 4 melanocyte 4 globus pallidus 2 arcuate nucleus 2 POMC (Homo sapiens)

Pain Link Frequency Relevance Heat Opioid 160 100.00 Enkephalin 148 100.00 antagonist 52 100.00 narcan 33 100.00 opioid receptor 23 100.00 Endogenous opioid 14 100.00 Catecholamine 8 100.00 Morphine 6 100.00 electroacupuncture 136 99.96 Inflammation 156 99.68

Disease Link Frequency Relevance Heat Natriuresis 1 100.00 Sprains And Strains 1 100.00 Sepsis 100 99.70 INFLAMMATION 163 99.68 Pressure And Volume Under Development 26 99.64 Cancer 26 99.20 Endometriosis (extended) 11 98.96 Secondary Adrenal Insufficiency 12 98.92 Reprotox - General 1 12 98.88 Hyperalgesia 40 98.76

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Event

Anatomy

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Speculation

Pain term

Disease term

The expression of POMC mRNA decreases when the cell lines are differentiated with retinoic acid or alpha-difluoromethylornithine.

Negative_regulation (decreases) of Gene_expression (expression) of POMC mRNA

1) Confidence 0.59 Published 1991 Journal Prog. Clin. Biol. Res. Section Abstract Doc Link 2068137 Disease Relevance 0.17 Pain Relevance 0.08

These results indicate that D can induce a significant decline in plasma levels of ACTH, beta-lipotropin, and beta-endorphin, the major circulating peptides from the C-terminal part of proopiocortin, and suggest that opioid peptides may be involved in the control of the functional activity of pituitary-adrenocortical activity in man.

Negative_regulation (decline) of Gene_expression (levels) of beta-endorphin in pituitary associated with opioid

2) Confidence 0.43 Published 1985 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2997256 Disease Relevance 0 Pain Relevance 0.18

Blockade of the production of met-enkephalin and enkephalin-containing intermediary peptides resulted in enhancement of the proliferative T cell response and inhibition of monocyte IL-6 secretion.

Negative_regulation (Blockade) of Gene_expression (production) of met-enkephalin in monocyte associated with enkephalin

3) Confidence 0.43 Published 1998 Journal J. Neuroimmunol. Section Abstract Doc Link 9600708 Disease Relevance 0 Pain Relevance 1.12

These data indicate that acute alcohol consumption induces significant alterations in plasma beta-endorphin, but not met-enkephalin levels, which are reversed after 5 weeks of abstinence.

Negative_regulation (reversed) of Gene_expression (levels) of met-enkephalin in plasma associated with enkephalin and alcohol

4) Confidence 0.42 Published 1992 Journal Alcohol Alcohol. Section Abstract Doc Link 1335722 Disease Relevance 0 Pain Relevance 0.40

These data indicate that acute alcohol consumption induces significant alterations in plasma beta-endorphin, but not met-enkephalin levels, which are reversed after 5 weeks of abstinence.

Negative_regulation (reversed) of Gene_expression (levels) of beta-endorphin in plasma associated with enkephalin and alcohol

5) Confidence 0.42 Published 1992 Journal Alcohol Alcohol. Section Abstract Doc Link 1335722 Disease Relevance 0 Pain Relevance 0.40

A significant negative relationship was found between oxytocin and ACTH levels, but not between oxytocin and cortisol levels.

Neg (not) Negative_regulation (between) of Neg (not) Gene_expression (levels) of ACTH

6) Confidence 0.40 Published 2009 Journal Breastfeed Med Section Body Doc Link 19731998 Disease Relevance 0 Pain Relevance 0

Theophylline did not influence significantly the glucagon-releasing effect of beta-endorphin as well as the reduced glucagon suppression.

Negative_regulation (reduced) of Gene_expression (suppression) of beta-endorphin

7) Confidence 0.40 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2551176 Disease Relevance 0.08 Pain Relevance 0.06

Mechanism of ACTH and prednisone

Negative_regulation (prednisone) of Gene_expression (Mechanism) of ACTH

8) Confidence 0.40 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695218 Disease Relevance 0.85 Pain Relevance 0.13

Naltrexone alone produced increases in plasma ACTH that were attenuated by the subsequent administration of noncontingent or response-contingent ethanol.

Negative_regulation (attenuated) of Gene_expression (produced) of ACTH in plasma

9) Confidence 0.40 Published 2004 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 15100607 Disease Relevance 0 Pain Relevance 0

Radioimmunoassays revealed the presence of beta-endorphin and methionine-enkephalin in these tumors.

Negative_regulation (revealed) of Gene_expression (presence) of beta-endorphin associated with cancer and enkephalin

10) Confidence 0.39 Published 1987 Journal J. Natl. Cancer Inst. Section Abstract Doc Link 2824913 Disease Relevance 0.59 Pain Relevance 0.64

These data show that oxytocin is capable of inhibiting the rise in ACTH and cortisol, but not in GH and PRL induced by physical exercise.

Negative_regulation (inhibiting) of Gene_expression (rise) of ACTH

11) Confidence 0.37 Published 1988 Journal Acta Endocrinol. Section Abstract Doc Link 2847472 Disease Relevance 0 Pain Relevance 0.39

Dexamethasone needs only to be given once daily, with bedtime administration being the most effective means to suppress ACTH and adrenal 19-carbon steroid production [31].

Negative_regulation (suppress) of Gene_expression (production) of ACTH associated with dexamethasone

12) Confidence 0.34 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2896848 Disease Relevance 0.15 Pain Relevance 0.23

The decrease in beta-endorphin levels during the luteal phase, compared with the follicular phase, in PMS patients was also significant (P = 0.0002).

Negative_regulation (decrease) of Gene_expression (levels) of beta-endorphin associated with dismenorea

13) Confidence 0.33 Published 1985 Journal Fertil. Steril. Section Abstract Doc Link 2934273 Disease Relevance 0.55 Pain Relevance 0.71

CFA-induced inflammation alone did not cause significant plasma ACTH changes. 3.2 ACTH (11–24) blocked EA anti-edema but not EA anti-hyperalgesia

Negative_regulation (blocked) of Gene_expression (changes.) of ACTH in plasma associated with pressure and volume under development, hyperalgesia, inflammation and electroacupuncture

14) Confidence 0.33 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2408560 Disease Relevance 0.52 Pain Relevance 0.68

We observed a significant decrease in the expression of opioid peptide precursors (proopiomelanocortin, proenkephalin, and prodynorphin) and of the kappa opioid receptor after 48 and 72 h of EtOH exposure (10 and 40 mM).

Negative_regulation (decrease) of Gene_expression (expression) of proopiomelanocortin associated with kappa opioid receptor and opioid

15) Confidence 0.32 Published 2008 Journal FASEB J. Section Abstract Doc Link 17934066 Disease Relevance 0.17 Pain Relevance 0.65

This report establishes the presence of mammalian-like proopiomelanocotropic hormone (POMC), and six of its peptides, including adrenocorticotropic hormone (ACTH) and melanocyte-stimulating hormone (MSH), in the immune tissues of the leech Theromyzon tessulatum.

Negative_regulation (establishes) of Gene_expression (presence) of ACTH in melanocyte

16) Confidence 0.30 Published 1997 Journal J. Immunol. Section Abstract Doc Link 9548480 Disease Relevance 0 Pain Relevance 0.06

This report establishes the presence of mammalian-like proopiomelanocotropic hormone (POMC), and six of its peptides, including adrenocorticotropic hormone (ACTH) and melanocyte-stimulating hormone (MSH), in the immune tissues of the leech Theromyzon tessulatum.

Negative_regulation (establishes) of Gene_expression (presence) of adrenocorticotropic hormone in melanocyte

17) Confidence 0.30 Published 1997 Journal J. Immunol. Section Abstract Doc Link 9548480 Disease Relevance 0 Pain Relevance 0.06

In the present study, we examined desensitization of the human delta-opioid receptor (hDOR) produced by endogenous opioid peptides Leu-enkephalin (Tyr-Gly-Gly-Phe-Leu) and Met-enkephalin (Tyr-Gly-Gly-Phe-Met), and the contribution of internalization in this process.

Spec (examined) Negative_regulation (desensitization) of Gene_expression (produced) of Met-enkephalin associated with endogenous opioid, enkephalin and opioid receptor

18) Confidence 0.25 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15102931 Disease Relevance 0 Pain Relevance 0.78

These results would suggest that the Met-enkephalin present in the pars intermedia of lampreys may not be derived from Proenkephalin, but may originate from another opioid precursor.

Neg (not) Negative_regulation (derived) of Gene_expression (present) of Met-enkephalin in pars intermedia associated with enkephalin and opioid

19) Confidence 0.23 Published 1992 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 1478444 Disease Relevance 0 Pain Relevance 1.05

Sepsis may result in decreased CRH or ACTH synthesis by inducing irreversible anatomical damage to the hypothalamus or the pituitary gland.

Negative_regulation (decreased) of Gene_expression (synthesis) of ACTH in pituitary gland associated with sepsis

20) Confidence 0.23 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.37 Pain Relevance 0

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